Dissecting key residues of a C4-dicarboxylic acid transporter to accelerate malate export in Myceliophthora

[1]  Yingfeng Li,et al.  Recent advances in microbial production of L-malic acid , 2022, Applied Microbiology and Biotechnology.

[2]  Chaoguang Tian,et al.  Development of a flow cytometry-based plating-free system for strain engineering in industrial fungi , 2021, Applied microbiology and biotechnology.

[3]  Oriol Vinyals,et al.  Highly accurate protein structure prediction with AlphaFold , 2021, Nature.

[4]  Chaoguang Tian,et al.  Transcriptional Profiling of Myceliophthora thermophila on Galactose and Metabolic Engineering for Improved Galactose Utilization , 2021, Frontiers in Microbiology.

[5]  G. Diallinas Transporter Specificity: A Tale of Loosened Elevator-Sliding. , 2021, Trends in biochemical sciences.

[6]  Xinyuan Liu,et al.  Identification and engineering a C4-dicarboxylate transporter for improvement of malic acid production in Aspergillus niger , 2020, Applied Microbiology and Biotechnology.

[7]  Chaoguang Tian,et al.  Direct production of commodity chemicals from lignocellulose using Myceliophthora thermophila. , 2020, Metabolic engineering.

[8]  Minghao Yin,et al.  EDock: blind protein–ligand docking by replica-exchange monte carlo simulation , 2020, Journal of Cheminformatics.

[9]  Chaoguang Tian,et al.  Metabolic engineering of the cellulolytic thermophilic fungus Myceliophthora thermophila to produce ethanol from cellobiose , 2020, Biotechnology for Biofuels.

[10]  Vratislav Šťovíček,et al.  Engineering energetically efficient transport of dicarboxylic acids in yeast Saccharomyces cerevisiae , 2019, Proceedings of the National Academy of Sciences.

[11]  S. Brar,et al.  Bioproduction of fumaric acid: an insight into microbial strain improvement strategies , 2019, Critical reviews in biotechnology.

[12]  Ara M. Abramyan,et al.  The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites , 2018, Proceedings of the National Academy of Sciences.

[13]  M. Jiang,et al.  Current advance in biological production of malic acid using wild type and metabolic engineered strains. , 2018, Bioresource technology.

[14]  Long Liu,et al.  Rewiring the reductive tricarboxylic acid pathway and L-malate transport pathway of Aspergillus oryzae for overproduction of L-malate. , 2017, Journal of biotechnology.

[15]  Lei Yang,et al.  Overexpression of a C4-dicarboxylate transporter is the key for rerouting citric acid to C4-dicarboxylic acid production in Aspergillus carbonarius , 2017, Microbial Cell Factories.

[16]  Liming Liu,et al.  Engineering rTCA pathway and C4-dicarboxylate transporter for l-malic acid production , 2017, Applied Microbiology and Biotechnology.

[17]  Chaoguang Tian,et al.  Development of a genome-editing CRISPR/Cas9 system in thermophilic fungal Myceliophthora species and its application to hyper-cellulase production strain engineering , 2017, Biotechnology for Biofuels.

[18]  Y. Jang,et al.  Production of succinic acid by metabolically engineered microorganisms. , 2016, Current opinion in biotechnology.

[19]  David E. Kim,et al.  Simultaneous Optimization of Biomolecular Energy Functions on Features from Small Molecules and Macromolecules. , 2016, Journal of chemical theory and computation.

[20]  L. Regan,et al.  Steric interactions determine side-chain conformations in protein cores. , 2016, Protein engineering, design & selection : PEDS.

[21]  Sudhir Kumar,et al.  MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. , 2016, Molecular biology and evolution.

[22]  S. Paiva,et al.  The Debaryomyces hansenii carboxylate transporters Jen1 homologues are functional in Saccharomyces cerevisiae. , 2015, FEMS yeast research.

[23]  M. Díaz,et al.  Microbial production of specialty organic acids from renewable and waste materials , 2015, Critical reviews in biotechnology.

[24]  Haishan Qi,et al.  Engineering Scheffersomyces stipitis for fumaric acid production from xylose. , 2015, Bioresource technology.

[25]  J. Xu,et al.  Development of genetic tools for Myceliophthora thermophila , 2015, BMC Biotechnology.

[26]  G. Bennett,et al.  Metabolic engineering of carbon and redox flow in the production of small organic acids , 2015, Journal of Industrial Microbiology & Biotechnology.

[27]  Xingxu Huang,et al.  sgRNAcas9: A Software Package for Designing CRISPR sgRNA and Evaluating Potential Off-Target Cleavage Sites , 2014, PloS one.

[28]  Xueli Zhang,et al.  Activating C4-dicarboxylate transporters DcuB and DcuC for improving succinate production , 2014, Applied Microbiology and Biotechnology.

[29]  Nan Xu,et al.  Metabolic engineering of Torulopsis glabrata for malate production. , 2013, Metabolic engineering.

[30]  Stephen H. Brown,et al.  Metabolic engineering of Aspergillus oryzae NRRL 3488 for increased production of l-malic acid , 2013, Applied Microbiology and Biotechnology.

[31]  Samuel L. DeLuca,et al.  Small-molecule ligand docking into comparative models with Rosetta , 2013, Nature Protocols.

[32]  S. Emr,et al.  Ubiquitin and membrane protein turnover: from cradle to grave. , 2012, Annual review of biochemistry.

[33]  Chris Morley,et al.  Open Babel: An open chemical toolbox , 2011, J. Cheminformatics.

[34]  Justin Powlowski,et al.  Comparative genomic analysis of the thermophilic biomass-degrading fungi Myceliophthora thermophila and Thielavia terrestris , 2011, Nature Biotechnology.

[35]  M. Casal,et al.  A substrate translocation trajectory in a cytoplasm‐facing topological model of the monocarboxylate/H+ symporter Jen1p , 2011, Molecular microbiology.

[36]  Marco Punta,et al.  Homolog Structure of the SLAC1 Anion Channel for Closing Stomata in Leaves , 2010, Nature.

[37]  G. Diallinas,et al.  Dynamic elements at both cytoplasmically and extracellularly facing sides of the UapA transporter selectively control the accessibility of substrates to their translocation pathway. , 2010, Journal of molecular biology.

[38]  D. Slotboom,et al.  Biochemical Characterization of the C4-Dicarboxylate Transporter DctA from Bacillus subtilis , 2010, Journal of bacteriology.

[39]  L. Wackett Metabolic engineering , 2009, Nature biotechnology.

[40]  Jack T. Pronk,et al.  Malic Acid Production by Saccharomyces cerevisiae : Engineering of Pyruvate Carboxylation , Oxaloacetate Reduction , and Malate Export † , 2007 .

[41]  M. Sauer,et al.  Microbial production of organic acids: expanding the markets. , 2008, Trends in biotechnology.

[42]  J. Stefan Rokem,et al.  Organic acids: old metabolites, new themes , 2006 .

[43]  D. Walters,et al.  The mitochondrial citrate transport protein: evidence for a steric interaction between glutamine 182 and leucine 120 and its relationship to the substrate translocation pathway and identification of other mechanistically essential residues. , 2006, Biochimica et biophysica acta.

[44]  G. Diallinas,et al.  A novel-type substrate-selectivity filter and ER-exit determinants in the UapA purine transporter. , 2006, Journal of molecular biology.

[45]  H. Matsumoto,et al.  Cytotoxic thio-malate is transported by both an aluminum-responsive malate efflux pathway in wheat and the MAE1 malate permease in Schizosaccharomyces pombe , 2006, Planta.

[46]  Rodrigo Lopez,et al.  Multiple sequence alignment with the Clustal series of programs , 2003, Nucleic Acids Res..

[47]  G. Unden,et al.  Functioning of DcuC as the C4-Dicarboxylate Carrier during Glucose Fermentation by Escherichia coli , 1999, Journal of bacteriology.

[48]  William R. Taylor,et al.  The rapid generation of mutation data matrices from protein sequences , 1992, Comput. Appl. Biosci..

[49]  Sharad Kumar,et al.  Ubiquitination and the Regulation of Membrane Proteins. , 2017, Physiological reviews.

[50]  Long Liu,et al.  Biological production of l-malate: recent advances and future prospects , 2017, World Journal of Microbiology and Biotechnology.