Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity
暂无分享,去创建一个
M. Janicot | L. Dillen | J. van Dun | M. Venet | W. Wouters | B. Janssen | G. Willemsens | C. Van Hove | B. M. van der Leede | W. Floren | R. Van Ginckel | B. V. D. Leede | J. Van heusden | H. Bruwiere | P. Moelans | G. Sanz | R. Ginckel | J. V. Dun | J. V. heusden | C. V. Hove | Hélène Bruwiere
[1] W. Miller. The emerging role of retinoids and retinoic acid metabolism blocking agents in the treatment of cancer , 1998, Cancer.
[2] B. van der Burg,et al. Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[3] L. Dillen,et al. The antiproliferative activity of all-trans-retinoic acid catabolites and isomers is differentially modulated by liarozole-fumarate in MCF-7 human breast cancer cells. , 1998, British Journal of Cancer.
[4] F. Dilworth,et al. cDNA Cloning of Human Retinoic Acid-metabolizing Enzyme (hP450RAI) Identifies a Novel Family of Cytochromes P450 (CYP26)* , 1997, The Journal of Biological Chemistry.
[5] B. van der Burg,et al. Autoinduction of Retinoic Acid Metabolism to Polar Derivatives with Decreased Biological Activity in Retinoic Acid-sensitive, but Not in Retinoic Acid-resistant Human Breast Cancer Cells* , 1997, The Journal of Biological Chemistry.
[6] F. Ramaekers,et al. Liarozole potentiates the all-trans-retinoic acid-induced structural remodelling in human breast carcinoma MCF-7 cells in vitro. , 1996, European journal of cell biology.
[7] J. H. Choi,et al. Highly specific cytochrome P450-like enzymes for all-trans-retinoic acid in T47D human breast cancer cells. , 1996, The Journal of clinical endocrinology and metabolism.
[8] D. End,et al. A rapid assay for measuring the metabolism of [3H]-retinoic acid in cell cultures. , 1995, Journal of pharmacological and toxicological methods.
[9] M. Moeremans,et al. Liarozole, an antitumor drug, modulates cytokeratin expression in the dunning AT‐6sq prostatic carcinoma through in situ accumulation of all‐trans‐retinoic acid , 1995, The Prostate.
[10] H. Scher,et al. Differences in the pharmacokinetic properties of orally administered all-trans-retinoic acid and 9-cis-retinoic acid in the plasma of nude mice. , 1994, Drug metabolism and disposition: the biological fate of chemicals.
[11] R. Warrell,et al. Elevated plasma lipid peroxide content correlates with rapid plasma clearance of all-trans-retinoic acid in patients with advanced cancer. , 1994, Cancer research.
[12] M. Coene,et al. Liarozole fumarate inhibits the metabolism of 4-keto-all-trans-retinoic acid. , 1994, Biochemical pharmacology.
[13] S. Lippman,et al. Phase I evaluation of all-trans-retinoic acid in adults with solid tumors. , 1993, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[14] H. Bossche. Inhibitors of P450-dependent steroid biosynthesis: From research to medical treatment , 1992, The Journal of Steroid Biochemistry and Molecular Biology.
[15] J. van Dun,et al. Effects of liarozole, a new antitumoral compound, on retinoic acid-induced inhibition of cell growth and on retinoic acid metabolism in MCF-7 human breast cancer cells. , 1992, Cancer research.
[16] E. Dmitrovsky,et al. Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia. , 1992, Blood.
[17] P. Janssen,et al. R 76713 and enantiomers: selective, nonsteroidal inhibitors of the cytochrome P450-dependent oestrogen synthesis. , 1990, Biochemical pharmacology.
[18] M. Kris,et al. Modulation of all-trans retinoic acid pharmacokinetics by liarozole , 2004, Cancer Chemotherapy and Pharmacology.
[19] L. Dillen,et al. Induction of the oxidative catabolism of retinoid acid in MCF-7 cells. , 1997, British Journal of Cancer.
[20] J. Schalken,et al. Antitumoral effects of liarozole in androgen-dependent and independent R3327-Dunning prostate adenocarcinomas. , 1994, The Journal of urology.
[21] H. Kornhuber,et al. Oral Liarozole as a Catabolic Inhibitor Potently Increases Retinoic Acid in vivo: First Experience from an Ongoing Therapeutic Trial in Highly Malignant Primary Brain Tumors , 1993 .
[22] P. Janssen,et al. R 75251, a new inhibitor of steroid biosynthesis , 1990, The Prostate.
[23] P. Janssen,et al. Antitumoral effects of R 75251 on the growth of transplantable R3327 prostatic adenocarcinoma in rats , 1990, The Prostate.