Identification of Symptom Phenotypes of Hand Osteoarthritis Using Hierarchical Clustering: Results From the DIGICOD Cohort

We aimed to delineate phenotypes in hand osteoarthritis (HOA) based on cardinal symptoms (pain, functional limitation, stiffness, and aesthetic discomfort).

[1]  R. Ramonda,et al.  Erosive hand osteoarthritis: latest findings and outlook , 2022, Nature Reviews Rheumatology.

[2]  J. Samuels,et al.  Current Epidemiology and Risk Factors for the Development of Hand Osteoarthritis , 2021, Current Rheumatology Reports.

[3]  B. Mohajer,et al.  Metabolic Syndrome and Osteoarthritis Distribution in the Hand Joints: A Propensity Score Matching Analysis From the Osteoarthritis Initiative , 2021, Journal of Rheumatology.

[4]  M. Dougados,et al.  The DIGICOD cohort: a hospital-based observational prospective cohort of patients with hand osteoarthritis - methodology and baseline characteristics of the population. , 2021, Joint bone spine.

[5]  B. Slatkowsky‐Christensen,et al.  Associations Between Ultrasound‐Detected Synovitis, Pain, and Function in Interphalangeal and Thumb Base Osteoarthritis: Data From the Nor‐Hand Cohort , 2020, Arthritis care & research.

[6]  M. Jurynec,et al.  Familial Clustering of Erosive Hand Osteoarthritis in a Large Statewide Cohort , 2020, Arthritis & rheumatology.

[7]  G. Guyatt,et al.  2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee , 2020, Arthritis care & research.

[8]  M. Marshall,et al.  Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management , 2018, Nature Reviews Rheumatology.

[9]  G. Herrero-Beaumont,et al.  2018 update of the EULAR recommendations for the management of hand osteoarthritis , 2018, Annals of the rheumatic diseases.

[10]  M. Gulati,et al.  Association of metabolic syndrome with knee and hand osteoarthritis: A community-based study of women. , 2018, Seminars in arthritis and rheumatism.

[11]  M. Kloppenburg,et al.  Thumb base osteoarthritis: A hand osteoarthritis subset requiring a distinct approach. , 2017, Best practice & research. Clinical rheumatology.

[12]  Jin Qin,et al.  Lifetime Risk of Symptomatic Hand Osteoarthritis: The Johnston County Osteoarthritis Project , 2017, Arthritis & rheumatology.

[13]  D. Felson,et al.  Increased prevalence and severity of radiographic hand osteoarthritis in patients with HIV-1 infection associated with metabolic syndrome: data from the cross-sectional METAFIB-OA study , 2016, Annals of the rheumatic diseases.

[14]  J. Reginster,et al.  Aesthetic discomfort in hand osteoarthritis: results from the LIège Hand Osteoarthritis Cohort (LIHOC) , 2015, Arthritis Research & Therapy.

[15]  C. Bombardier,et al.  Development of Multinational Definitions of Minimal Clinically Important Improvement and Patient Acceptable Symptomatic State in Osteoarthritis , 2015, Arthritis care & research.

[16]  Yufeng Liu,et al.  Statistical significance for hierarchical clustering , 2014, Biometrics.

[17]  D. M. van der Heijde,et al.  Radiographic scoring methods in hand osteoarthritis--a systematic literature search and descriptive review. , 2014, Osteoarthritis and cartilage.

[18]  F. Carrat,et al.  Assessment and determinants of aesthetic discomfort in hand osteoarthritis , 2011, Annals of the rheumatic diseases.

[19]  Avan Aihie Sayer,et al.  A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. , 2011, Age and ageing.

[20]  D. A. van der Windt,et al.  Radiographic thumb osteoarthritis: frequency, patterns and associations with pain and clinical assessment findings in a community-dwelling population , 2010, Rheumatology.

[21]  Christian Hennig,et al.  Cluster-wise assessment of cluster stability , 2007, Comput. Stat. Data Anal..

[22]  F. Kainberger,et al.  Research in hand osteoarthritis: time for reappraisal and demand for new strategies. An opinion paper , 2007, Annals of the rheumatic diseases.

[23]  R. Buchbinder,et al.  Dimensionality and clinical importance of pain and disability in hand osteoarthritis: Development of the Australian/Canadian (AUSCAN) Osteoarthritis Hand Index. , 2002, Osteoarthritis and cartilage.

[24]  G. Verbruggen,et al.  Numerical scoring systems for the anatomic evolution of osteoarthritis of the finger joints. , 1996, Arthritis and rheumatism.

[25]  W. Murphy,et al.  The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. , 1990, Arthritis and rheumatism.

[26]  G. W. Milligan,et al.  An examination of procedures for determining the number of clusters in a data set , 1985 .

[27]  K Henriksen,et al.  Osteoarthritis--a case for personalized health care? , 2014, Osteoarthritis and cartilage.

[28]  G. Gold,et al.  Atlas of individual radiographic features in osteoarthritis, revised. , 2007, Osteoarthritis and cartilage.

[29]  J. Mckenney,et al.  Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). , 2001, JAMA.

[30]  R. Tibshirani,et al.  Estimating the number of clusters in a data set via the gap statistic , 2000 .

[31]  André Hardy,et al.  An examination of procedures for determining the number of clusters in a data set , 1994 .

[32]  G. Huston The Hospital Anxiety and Depression Scale. , 1987, The Journal of rheumatology.