Metabolic design based on a coupled gene expression-metabolic network model of tryptophan production in Escherichia coli.

[1]  D. Oxender,et al.  Amino Acid Transport Systems in Escherichia coli K12 , 1968 .

[2]  Hyperproduction of tryptophan by Escherichia coli: genetic manipulation of the pathways leading to tryptophan formation , 1979, Applied and environmental microbiology.

[3]  Lawrence P. Wackett,et al.  Expression of naphthalene oxidation genes in Escherichia coli results in the biosynthesis of indigo. , 1983, Science.

[4]  C. D. Gelatt,et al.  Optimization by Simulated Annealing , 1983, Science.

[5]  R. Gunsalus,et al.  Interaction of the Escherichia coli trp aporepressor with its ligand, L-tryptophan. , 1986, The Journal of biological chemistry.

[6]  S. Sinha.  Theoretical study of tryptophan operon: Application in microbial technology , 1988, Biotechnology and bioengineering.

[7]  F. Neidhardt,et al.  Physiology of the bacterial cell : a molecular approach , 1990 .

[8]  C. Yanofsky,et al.  Physiological studies of tryptophan transport and tryptophanase operon induction in Escherichia coli , 1991, Journal of bacteriology.

[9]  J. W. Frost,et al.  Identification and removal of impediments to biocatalytic synthesis of aromatics from D-glucose: rate-limiting enzymes in the common pathway of aromatic amino acid biosynthesis , 1993 .

[10]  B. Palsson,et al.  Metabolic capabilities of Escherichia coli: I. synthesis of biosynthetic precursors and cofactors. , 1993, Journal of theoretical biology.

[11]  B. T. Koh,et al.  A Simple genetically structured model of trp repressor–operator interactions , 1993, Biotechnology and bioengineering.

[12]  B. Palsson,et al.  Metabolic Capabilities of Escherichia coli II. Optimal Growth Patterns , 1993 .

[13]  J. Liao,et al.  Pathway analysis, engineering, and physiological considerations for redirecting central metabolism. , 1996, Biotechnology and bioengineering.

[14]  A. Zeng,et al.  Model analysis concerning the effects of growth rate and intracellular tryptophan level on the stability and dynamics of tryptophan biosynthesis in bacteria , 1997 .

[15]  G. Stephanopoulos,et al.  Flux amplification in complex metabolic networks , 1997 .

[16]  M. Reuss,et al.  In vivo analysis of metabolic dynamics in Saccharomyces cerevisiae: II. Mathematical model. , 1997, Biotechnology and bioengineering.

[17]  B. T. Koh,et al.  Genetically structured mathematical modeling of trp attenuator mechanism. , 1998, Biotechnology and bioengineering.

[18]  D. Fell,et al.  Detection of elementary flux modes in biochemical networks: a promising tool for pathway analysis and metabolic engineering. , 1999, Trends in biotechnology.

[19]  E. Gilles,et al.  The organization of metabolic reaction networks. II. Signal processing in hierarchical structured functional units. , 2001, Metabolic engineering.

[20]  W. Leuchtenberger.  Amino Acids – Technical Production and Use , 2001 .

[21]  M C Mackey,et al.  Dynamic regulation of the tryptophan operon: a modeling study and comparison with experimental data. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[22]  M. Wubbolts,et al.  Metabolic engineering for microbial production of aromatic amino acids and derived compounds. , 2001, Metabolic engineering.

[23]  E. Gilles,et al.  The organization of metabolic reaction networks. III. Application for diauxic growth on glucose and lactose. , 2001, Metabolic engineering.

[24]  Edgar Voss,et al.  Enzyme-catalyzed processes in pharmaceutical industry , 2001 .

[25]  C. Chassagnole,et al.  Dynamic modeling of the central carbon metabolism of Escherichia coli. , 2002, Biotechnology and bioengineering.