Design and synthesis of novel tricyclic benzoxazines as potent 5-HT(1A/B/D) receptor antagonists leading to the discovery of 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide (GSK588045).
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S. Bromidge | J. Watson | A. Worby | M. Gianotti | A. Sava | D. Donati | Barbara Bertani | P. Cavanni | I. Sartori | R. Arban | S. Fontana | Laura Zonzini | C. Leslie | Silvia Bison | Manuela Borriello | Enrica Granci | V. Zucchelli | A. Pasquarello | G. Dal Forno | Laurie J. Gordon | Romano Di-Fabio | Luca G Moccia