High‐pitched breath sounds indicate airflow limitation in asymptomatic asthmatic children

Background and objective:  Asthmatic children may have airway dysfunction even when asymptomatic, indicating that their long‐term treatment is less than optimal. Although airway dysfunction can be identified on lung function testing, performing these tests can be difficult in infants. We studied whether breath sounds reflect subtle airway dysfunction in asthmatic children.

[1]  R. Djukanović,et al.  Mucosal inflammation in asthma. , 1990, The American review of respiratory disease.

[2]  A. Ferguson Persisting airway obstruction in asymptomatic children with asthma with normal peak expiratory flow rates. , 1988, The Journal of allergy and clinical immunology.

[3]  L. Boulet,et al.  Airway responsiveness and bronchial-wall thickness in asthma with or without fixed airflow obstruction. , 1995, American journal of respiratory and critical care medicine.

[4]  K. P. Van de Woestijne,et al.  Maximum expiratory flow-volume curves and airway conductance in children and adolescents. , 1969, Journal of applied physiology.

[5]  M. H. Williams,et al.  Relationship of wheezing to the severity of obstruction in asthma. , 1983, Archives of internal medicine.

[6]  T. Haahtela,et al.  Airway mucosal inflammation even in patients with newly diagnosed asthma. , 1993, The American review of respiratory disease.

[7]  P. Paré,et al.  Small airways dimensions in asthma and in chronic obstructive pulmonary disease. , 1993, The American review of respiratory disease.

[8]  A. Woolcock,et al.  Rate of decline of lung function in subjects with asthma. , 1987, European journal of respiratory diseases.

[9]  J Vestbo,et al.  A 15-year follow-up study of ventilatory function in adults with asthma. , 1998, The New England journal of medicine.

[10]  A R Sovijärvi,et al.  Frequency distribution of breath sounds as an indicator of bronchoconstriction during histamine challenge test in asthmatic children , 1994, Pediatric pulmonology.

[11]  A. Stewart,et al.  Airway wall remodelling in asthma: a novel target for the development of anti-asthma drugs. , 1993, Trends in pharmacological sciences.

[12]  P. Forgacs,et al.  Crackles and wheezes. , 1967, Lancet.

[13]  Campbell Moreland,et al.  TERATOMA OF THE TESTIS , 1982, The Lancet.