Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

[1]  L. Klein,et al.  Regulatory T cell lineage commitment in the thymus. , 2011, Seminars in immunology.

[2]  F. Regateiro,et al.  Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance , 2011, The Journal of experimental medicine.

[3]  T. Chatila,et al.  A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. , 2011, Immunity.

[4]  J. Bluestone,et al.  Regulatory T cells: stability revisited. , 2011, Trends in immunology.

[5]  S. Hori Regulatory T cell plasticity: beyond the controversies. , 2011, Trends in immunology.

[6]  C. Hsieh,et al.  Becoming self-aware: the thymic education of regulatory T cells. , 2011, Current opinion in immunology.

[7]  Shohei Hori,et al.  Developmental plasticity of Foxp3+ regulatory T cells. , 2010, Current opinion in immunology.

[8]  Christophe Benoist,et al.  Stability of the Regulatory T Cell Lineage in Vivo , 2010, Science.

[9]  R. Baumgrass,et al.  Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells , 2010, Journal of Molecular Medicine.

[10]  Y. Belkaid,et al.  Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells , 2010, The Journal of Immunology.

[11]  A. Rudensky,et al.  Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate , 2010, Nature.

[12]  Gisen Kim,et al.  Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis , 2009, Nature Immunology.

[13]  J. Bluestone,et al.  Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo , 2009, Nature Immunology.

[14]  S. Zelenay,et al.  Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions , 2009, European journal of immunology.

[15]  Keiichiro Suzuki,et al.  Preferential Generation of Follicular B Helper T Cells from Foxp3+ T Cells in Gut Peyer's Patches , 2009, Science.

[16]  B. Malissen,et al.  Heterogeneity of natural Foxp3+ T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity , 2009, Proceedings of the National Academy of Sciences.

[17]  Alf Hamann,et al.  Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage? , 2009, Nature Reviews Immunology.

[18]  C. Hsieh,et al.  Antigen-specific peripheral shaping of the natural regulatory T cell population , 2008, The Journal of experimental medicine.

[19]  H. Yee,et al.  Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation. , 2008, Immunity.

[20]  Chen Dong,et al.  Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. , 2008, Immunity.

[21]  K. Kretschmer,et al.  DNA methylation controls Foxp3 gene expression , 2008, European journal of immunology.

[22]  Christophe Benoist,et al.  Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. , 2007, Immunity.

[23]  I. Türbachova,et al.  DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3+ conventional T cells , 2007, European journal of immunology.

[24]  E. Shevach,et al.  Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. , 2007, Blood.

[25]  W. Leonard,et al.  CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation , 2007, The Journal of experimental medicine.

[26]  W. Strober,et al.  Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β , 2007, The Journal of Immunology.

[27]  M. Roncarolo,et al.  Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. , 2007, International immunology.

[28]  A. Rudensky,et al.  Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3 , 2007, Nature Immunology.

[29]  Edgar Schmitt,et al.  Epigenetic Control of the foxp3 Locus in Regulatory T Cells , 2007, PLoS biology.

[30]  T. Huizinga,et al.  Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells , 2007, European journal of immunology.

[31]  H. Fehling,et al.  Faithful activation of an extra‐bright red fluorescent protein in “knock‐in” Cre‐reporter mice ideally suited for lineage tracing studies , 2007, European journal of immunology.

[32]  J. Ritz,et al.  IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. , 2006, Blood.

[33]  A. Rudensky,et al.  Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[34]  S. Ziegler FOXP3: of mice and men. , 2006, Annual review of immunology.

[35]  M. Nussenzweig,et al.  Inducing and expanding regulatory T cell populations by foreign antigen , 2005, Nature Immunology.

[36]  A. Rudensky,et al.  Regulatory T cell lineage specification by the forkhead transcription factor foxp3. , 2005, Immunity.

[37]  D. Zélénika,et al.  Induction of foxP3+ Regulatory T Cells in the Periphery of T Cell Receptor Transgenic Mice Tolerized to Transplants1 , 2004, The Journal of Immunology.

[38]  S. Sakaguchi Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. , 2004, Annual review of immunology.

[39]  Li Li,et al.  Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3 , 2003, The Journal of experimental medicine.

[40]  A. Rudensky,et al.  Control of immune homeostasis by naturally arising regulatory CD4+ T cells. , 2003, Current opinion in immunology.

[41]  F. Ramsdell,et al.  An essential role for Scurfin in CD4+CD25+ T regulatory cells , 2003, Nature Immunology.

[42]  A. Rudensky,et al.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells , 2003, Nature Immunology.

[43]  C. Pénit,et al.  Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[44]  D. Godfrey,et al.  Recent thymic emigrants are distinct from most medullary thymocytes , 1997, European journal of immunology.

[45]  M. Toda,et al.  Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. , 1995, Journal of immunology.

[46]  W. Paul,et al.  Neonates support lymphopenia-induced proliferation. , 2003, Immunity.

[47]  Supporting Online Material , 2002 .

[48]  Pei-Yun Tsai,et al.  Ar Ticle Identification of an Immediate Foxp3  Precursor to Foxp3 + Regulatory T Cells in Peripheral Lymphoid Organs of Nonmanipulated Mice , 2022 .