Use of the Chatbot “Vivibot” to Deliver Positive Psychology Skills and Promote Well-Being Among Young People After Cancer Treatment: Randomized Controlled Feasibility Trial

Background Positive psychology interventions show promise for reducing psychosocial distress associated with health adversity and have the potential to be widely disseminated to young adults through technology. Objective This pilot randomized controlled trial examined the feasibility of delivering positive psychology skills via the Vivibot chatbot and its effects on key psychosocial well-being outcomes in young adults treated for cancer. Methods Young adults (age 18-29 years) were recruited within 5 years of completing active cancer treatment by using the Vivibot chatbot on Facebook messenger. Participants were randomized to either immediate access to Vivibot content (experimental group) or access to only daily emotion ratings and access to full chatbot content after 4 weeks (control). Created using a human-centered design process with young adults treated for cancer, Vivibot content includes 4 weeks of positive psychology skills, daily emotion ratings, video, and other material produced by survivors, and periodic feedback check-ins. All participants were assessed for psychosocial well-being via online surveys at baseline and weeks 2, 4, and 8. Analyses examined chatbot engagement and open-ended feedback on likability and perceived helpfulness and compared experimental and control groups with regard to anxiety and depression symptoms and positive and negative emotion changes between baseline and 4 weeks. To verify the main effects, follow-up analyses compared changes in the main outcomes between 4 and 8 weeks in the control group once participants had access to all chatbot content. Results Data from 45 young adults (36 women; mean age: 25 [SD 2.9]; experimental group: n=25; control group: n=20) were analyzed. Participants in the experimental group spent an average of 74 minutes across an average of 12 active sessions chatting with Vivibot and rated their experience as helpful (mean 2.0/3, SD 0.72) and would recommend it to a friend (mean 6.9/10; SD 2.6). Open-ended feedback noted its nonjudgmental nature as a particular benefit of the chatbot. After 4 weeks, participants in the experimental group reported an average reduction in anxiety of 2.58 standardized t-score units, while the control group reported an increase in anxiety of 0.7 units. A mixed-effects models revealed a trend-level (P=.09) interaction between group and time, with an effect size of 0.41. Those in the experimental group also experienced greater reductions in anxiety when they engaged in more sessions (z=–1.9, P=.06). There were no significant (or trend level) effects by group on changes in depression, positive emotion, or negative emotion. Conclusions The chatbot format provides a useful and acceptable way of delivering positive psychology skills to young adults who have undergone cancer treatment and supports anxiety reduction. Further analysis with a larger sample size is required to confirm this pattern.

[1]  J. Moskowitz,et al.  Well-being interventions for individuals with diabetes: A systematic review. , 2019, Diabetes research and clinical practice.

[2]  Russell Fulmer,et al.  Using Psychological Artificial Intelligence (Tess) to Relieve Symptoms of Depression and Anxiety: Randomized Controlled Trial , 2018, JMIR mental health.

[3]  J. Moskowitz,et al.  Feasibility of an Internet-based positive psychological intervention for hemodialysis patients with symptoms of depression , 2018, Social work in health care.

[4]  Krysta S. Barton,et al.  Hope and benefit finding: Results from the PRISM randomized controlled trial , 2018, Pediatric blood & cancer.

[5]  M. Bradford,et al.  Promoting resilience in adolescents and young adults with cancer: Results from the PRISM randomized controlled trial , 2018, Cancer.

[6]  Jessica A. Chen,et al.  Conversational agents in healthcare: a systematic review , 2018, J. Am. Medical Informatics Assoc..

[7]  Nicole D. Gehring,et al.  eMental Healthcare Technologies for Anxiety and Depression in Childhood and Adolescence: Systematic Review of Studies Reporting Implementation Outcomes , 2018, JMIR mental health.

[8]  Danielle E. Ramo,et al.  A randomized controlled evaluation of the tobacco status project, a Facebook intervention for young adults , 2018, Addiction.

[9]  Susan A. Mangan,et al.  Claremont Purpose Scale: A Measure that Assesses the Three Dimensions of Purpose among Adolescents , 2018 .

[10]  Matthew D. Lieberman,et al.  Putting Feelings Into Words: Affect Labeling as Implicit Emotion Regulation , 2018 .

[11]  A. Mitchell,et al.  PROMIS depression measures perform similarly to legacy measures relative to a structured diagnostic interview for depression in cancer patients , 2018, Quality of Life Research.

[12]  J. Moskowitz,et al.  A randomized pilot trial of a positive affect skill intervention (lessons in linking affect and coping) for women with metastatic breast cancer , 2017, Psycho-oncology.

[13]  L. Hartling,et al.  How do eHealth Programs for Adolescents With Depression Work? A Realist Review of Persuasive System Design Components in Internet-Based Psychological Therapies , 2017, Journal of medical Internet research.

[14]  Megan A. Moreno,et al.  A Fitbit and Facebook mHealth intervention for promoting physical activity among adolescent and young adult childhood cancer survivors: A pilot study , 2017, Pediatric blood & cancer.

[15]  K. Fitzpatrick,et al.  Delivering Cognitive Behavior Therapy to Young Adults With Symptoms of Depression and Anxiety Using a Fully Automated Conversational Agent (Woebot): A Randomized Controlled Trial , 2017, JMIR mental health.

[16]  J. Pole,et al.  Instruments to measure anxiety in children, adolescents, and young adults with cancer: a systematic review , 2017, Supportive Care in Cancer.

[17]  Claire C. Conley,et al.  Self-Efficacy for Coping With Cancer: Revision of the Cancer Behavior Inventory (Version 3.0) , 2017, Psychological assessment.

[18]  Abigail W. Batchelder,et al.  Randomized Controlled Trial of a Positive Affect Intervention for People Newly Diagnosed With HIV , 2017, Journal of consulting and clinical psychology.

[19]  J. Milam,et al.  Supporting long‐term follow‐up of young adult survivors of childhood cancer: Correlates of healthcare self‐efficacy , 2017, Pediatric blood & cancer.

[20]  D. Cella,et al.  Clinical validity of PROMIS Depression, Anxiety, and Anger across diverse clinical samples. , 2016, Journal of clinical epidemiology.

[21]  M. Charlson,et al.  Results from the Trial Using Motivational Interviewing, Positive Affect, and Self-Affirmation in African Americans with Hypertension (TRIUMPH). , 2016, Ethnicity & Disease.

[22]  L. Sender,et al.  Adolescent and young adult patients with cancer: a milieu of unique features , 2015, Nature Reviews Clinical Oncology.

[23]  Rachel A. Millstein,et al.  Positive Psychological Interventions for Patients with Type 2 Diabetes: Rationale, Theoretical Model, and Intervention Development , 2015, Journal of diabetes research.

[24]  J. Yi-Frazier,et al.  Promoting Resilience in Stress Management: A Pilot Study of a Novel Resilience-Promoting Intervention for Adolescents and Young Adults With Serious Illness. , 2015, Journal of pediatric psychology.

[25]  P. Nathan,et al.  Age-dependent changes in health status in the Childhood Cancer Survivor cohort. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[26]  Amy L Lauer Treatment of Anxiety and Depression in Adolescents and Young Adults With Cancer , 2015, Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses.

[27]  J. Yi-Frazier,et al.  Contributors and Inhibitors of Resilience Among Adolescents and Young Adults with Cancer. , 2014, Journal of adolescent and young adult oncology.

[28]  J. Arnett,et al.  The new life stage of emerging adulthood at ages 18-29 years: implications for mental health. , 2014, The lancet. Psychiatry.

[29]  Laura R. Saslow,et al.  An online positive affect skills intervention reduces depression in adults with type 2 diabetes , 2014, The journal of positive psychology.

[30]  J. Yi-Frazier,et al.  Resilience among patients across the cancer continuum: diverse perspectives. , 2014, Clinical journal of oncology nursing.

[31]  David C. Mohr,et al.  Realizing the Potential of Behavioral Intervention Technologies , 2013 .

[32]  Yun Li,et al.  Trajectories of psychological distress in adolescent and young adult patients with cancer: a 1-year longitudinal study. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[33]  Bethany E. Kok,et al.  How Positive Emotions Build Physical Health , 2013, Psychological science.

[34]  J. Moskowitz,et al.  A positive affect intervention for people experiencing health-related stress: Development and non-randomized pilot test , 2012, Journal of health psychology.

[35]  M. Andrykowski,et al.  Physical and mental health status and health behaviors of childhood cancer survivors: Findings from the 2009 BRFSS survey , 2012, Pediatric blood & cancer.

[36]  Martin T. Wells,et al.  A randomized controlled trial of positive-affect intervention and medication adherence in hypertensive African Americans. , 2012, Archives of internal medicine.

[37]  Martin T. Wells,et al.  A randomized controlled trial of positive-affect induction to promote physical activity after percutaneous coronary intervention. , 2012, Archives of internal medicine.

[38]  Rita C. Seabrook,et al.  Development of a positive psychology intervention for patients with acute cardiovascular disease , 2011, Heart international.

[39]  Daniel J Buysse,et al.  The Patient-Reported Outcomes Measurement Information System (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005-2008. , 2010, Journal of clinical epidemiology.

[40]  C. Kuehni,et al.  Psychological distress in adult survivors of childhood cancer: the Swiss Childhood Cancer Survivor study. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[41]  C. Recklitis,et al.  Psychological status in childhood cancer survivors: a report from the Childhood Cancer Survivor Study. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[42]  Sonja Lyubomirsky,et al.  Enhancing well-being and alleviating depressive symptoms with positive psychology interventions: a practice-friendly meta-analysis. , 2009, Journal of clinical psychology.

[43]  B. Fredrickson,et al.  Open hearts build lives: positive emotions, induced through loving-kindness meditation, build consequential personal resources. , 2008, Journal of personality and social psychology.

[44]  A. Steptoe,et al.  Positive Psychological Well-Being and Mortality: A Quantitative Review of Prospective Observational Studies , 2008, Psychosomatic medicine.

[45]  M. Zeegers,et al.  Health‐status of adult survivors of childhood cancer: A large‐scale population‐based study from the British childhood cancer survivor study , 2007, International journal of cancer.

[46]  Sheldon Cohen,et al.  Positive Affect and Health , 2006 .

[47]  Sheldon Cohen,et al.  Does positive affect influence health? , 2005, Psychological bulletin.

[48]  Rosalind W. Picard,et al.  Establishing the computer-patient working alliance in automated health behavior change interventions. , 2005, Patient education and counseling.

[49]  J. Moskowitz,et al.  Positive Affect Predicts Lower Risk of AIDS Mortality , 2003, Psychosomatic medicine.

[50]  J. Moskowitz,et al.  Positive affect and the other side of coping. , 2000, The American psychologist.

[51]  P. Maguire,et al.  The effect of psychological interventions on anxiety and depression in cancer patients: results of two meta-analyses , 1999, British Journal of Cancer.

[52]  P. Lachenbruch Statistical Power Analysis for the Behavioral Sciences (2nd ed.) , 1989 .

[53]  A. Jemal,et al.  Cancer statistics, 2018 , 2018, CA: a cancer journal for clinicians.

[54]  Petter Bae Brandtzæg,et al.  Chatbots as a new user interface for providing health information to young people , 2018 .

[55]  G. Arbanas Diagnostic and Statistical Manual of Mental Disorders (DSM-5) , 2015 .

[56]  Gerben J Westerhof,et al.  Evaluating the psychometric properties of the Mental Health Continuum-Short Form (MHC-SF). , 2011, Journal of clinical psychology.

[57]  J. Moskowitz,et al.  Positive affect uniquely predicts lower risk of mortality in people with diabetes. , 2008, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[58]  M. Seligman,et al.  Positive psychology progress: empirical validation of interventions. , 2005, The American psychologist.

[59]  N. Z. Hampton,et al.  Self-Efficacy and Quality of Life in People with Spinal Cord Injuries in China. , 2000 .

[60]  M. Jerusalem,et al.  Adaptation and validation of an estonian version of the general self-efficacy scale (ESES) , 1999 .

[61]  Rascon [The National Cancer Institute]. , 1953, Boletin cultural e informativo - Consejo General de Colegios Medicos de Espana.