A Way Forward

One of the emerging concepts in the field of biomedical engineering is the ‘Bedside-Bench-Bedside’ concept. The development of any new biomaterials/tissue engineered product/translational approach should be driven by the patient’s need. The specific need to treat a specific disease should trigger the cascade of research activities at the labscale (‘bench’ work), which should involve material fabrication followed by in vitro and in vivo biological property assessment of a select group of implants. The final stage of taking the scientific research related to device/implant development to a patient’s bedside requires clinical trials, regulatory approval and product commercialization. In the above backdrop, this chapter summarises the author’s perspective on some of the issues relevant to the ‘Bedside-Bench-Bedside’ concept together with the smart and innovative design concepts of bone tissue engineering.

[1]  R. Cabrini,et al.  Osteoconductivity of strontium-doped bioactive glass particles: a histomorphometric study in rats. , 2010, Journal of biomedical materials research. Part A.

[2]  Mei-Chin Chen,et al.  Electrically conductive nanofibers with highly oriented structures and their potential application in skeletal muscle tissue engineering. , 2013, Acta biomaterialia.

[3]  Bikramjit Basu,et al.  Strength reliability and in vitro degradation of three-dimensional powder printed strontium-substituted magnesium phosphate scaffolds. , 2016, Acta biomaterialia.

[4]  Justin A. Blanco,et al.  Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. , 2010, Nature materials.

[5]  J. Rödel,et al.  Evolution of defect size and strength of porous alumina during sintering , 2000 .

[6]  A. Mäkitie,et al.  Inaccuracies in additive manufactured medical skull models caused by the DICOM to STL conversion process. , 2014, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[7]  David J. Mooney,et al.  Biomaterials based strategies for skeletal muscle tissue engineering: existing technologies and future trends. , 2015, Biomaterials.

[8]  T. Govindaraju,et al.  Pigmented Silk Nanofibrous Composite for Skeletal Muscle Tissue Engineering , 2016, Advanced healthcare materials.

[9]  Robert Langer,et al.  Biocompatibility of biodegradable semiconducting melanin films for nerve tissue engineering. , 2009, Biomaterials.

[10]  David C. Dunand,et al.  Processing of Titanium Foams , 2004 .

[11]  Olivier Gauthier,et al.  In vivo bone regeneration with injectable calcium phosphate biomaterial: a three-dimensional micro-computed tomographic, biomechanical and SEM study. , 2005, Biomaterials.

[12]  Peter X. Ma,et al.  Nanofibrous hollow microspheres self-assembled from star-shaped polymers as injectable cell carriers for knee repair , 2011, Nature materials.

[13]  Sook Hee Ku,et al.  Synergic effects of nanofiber alignment and electroactivity on myoblast differentiation. , 2012, Biomaterials.

[14]  S. Benitah,et al.  Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche , 2013, Nature Reviews Molecular Cell Biology.

[15]  R. Pilliar,et al.  Calcium phosphate sol-gel-derived thin films on porous-surfaced implants for enhanced osteoconductivity. Part II: Short-term in vivo studies. , 2004, Biomaterials.

[16]  J. Rödel,et al.  Evolution of Young's Modulus, Strength, and Microstructure during Liquid‐Phase Sintering , 2005 .