A New Model of a 3D-Printed Shell with Convex Drug Release Profile

The objective of this study was to fabricate a tablet with a convex drug release profile. A circumscribed sphere with a regular tetrahedron (pyramid) cavity shell model was created by a computer-aided design (CAD) program and printed by a 3D printer. Paracetamol (APAP) mixed with polyvinyl alcohol (PVA) gel was filled into the cavity. The tablets were obtained through drying. The release profile was obtained by detecting the APAP concentration in phosphate buffer solution through ultraviolet absorption spectrophotometry. Along with the decrement of tablet diameter, drug exposure area gradually increases the release rate of the drug. The results indicate that the release profile from a 3D-printed PVA shell with a tetrahedron cavity is increasing with no residue after dissolution. Potential fields of application may include hypotensors and other types of personalized medicines. Further studies are necessary to explore the potential application of more structures.

[1]  R. Marfella,et al.  Morning Blood Pressure Peak, QT Intervals, and Sympathetic Activity in Hypertensive Patients , 2003, Hypertension.

[2]  Clemens A van Blitterswijk,et al.  Osteoconduction and osteoinduction of low-temperature 3D printed bioceramic implants. , 2008, Biomaterials.

[3]  Waqar Ahmed,et al.  Emergence of 3D Printed Dosage Forms: Opportunities and Challenges , 2016, Pharmaceutical Research.

[4]  Siowling Soh,et al.  Printing Tablets with Fully Customizable Release Profiles for Personalized Medicine , 2015, Advanced materials.

[5]  T. Wheeler,et al.  Cancer-Related Axonogenesis and Neurogenesis in Prostate Cancer , 2008, Clinical Cancer Research.

[6]  Kaufui Wong,et al.  A Review of Additive Manufacturing , 2012 .

[7]  A. Basit,et al.  Effect of geometry on drug release from 3D printed tablets. , 2015, International journal of pharmaceutics.

[8]  M. Khan,et al.  A new chapter in pharmaceutical manufacturing: 3D‐printed drug products☆, ☆☆ , 2017, Advanced drug delivery reviews.

[9]  M. A. Alhnan,et al.  Fabrication of extended-release patient-tailored prednisolone tablets via fused deposition modelling (FDM) 3D printing. , 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[10]  Niklas Sandler,et al.  Towards fabrication of 3D printed medical devices to prevent biofilm formation. , 2014, International journal of pharmaceutics.

[11]  Abdul W. Basit,et al.  Stereolithographic ( SLA ) 3 D Printing of Oral Modified-Release 1 Dosage Forms 2 , 2016 .

[12]  Abdul W. Basit,et al.  Stereolithographic (SLA) 3D printing of oral modified-release dosage forms. , 2016, International journal of pharmaceutics.

[13]  Simon Gaisford,et al.  Fabrication of controlled-release budesonide tablets via desktop (FDM) 3D printing. , 2015, International journal of pharmaceutics.

[14]  Peter A Meléndez,et al.  Thermal inkjet application in the preparation of oral dosage forms: dispensing of prednisolone solutions and polymorphic characterization by solid-state spectroscopic techniques. , 2008, Journal of pharmaceutical sciences.

[15]  M. Alexander,et al.  3D printing of tablets containing multiple drugs with defined release profiles. , 2015, International journal of pharmaceutics.

[16]  M. Alexander,et al.  3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. , 2015, Journal of controlled release : official journal of the Controlled Release Society.