Reverse Engineering Applied to Red Human Hair Pheomelanin Reveals Redox-Buffering as a Pro-Oxidant Mechanism

[1]  Erik E. Josberger,et al.  Protonic and Electronic Transport in Hydrated Thin Films of the Pigment Eumelanin , 2015 .

[2]  P. Ambrico,et al.  A Photoresponsive Red‐Hair‐Inspired Polydopamine‐Based Copolymer for Hybrid Photocapacitive Sensors , 2014 .

[3]  G. Monfrecola,et al.  Pheomelanin‐induced oxidative stress: bright and dark chemistry bridging red hair phenotype and melanoma , 2014, Pigment cell & melanoma research.

[4]  V. Sundström,et al.  Superior photoprotective motifs and mechanisms in eumelanins uncovered. , 2014, Journal of the American Chemical Society.

[5]  Gregory F Payne,et al.  Information processing through a bio-based redox capacitor: signatures for redox-cycling. , 2014, Bioelectrochemistry.

[6]  Tamar Partskhaladze,et al.  Electron spin resonance (ESR/EPR) of free radicals observed in human red hair: a new, simple empirical method of determination of pheomelanin/eumelanin ratio in hair , 2014, Magnetic resonance in chemistry : MRC.

[7]  V. Sundström,et al.  Photochemistry of Pheomelanin Building Blocks and Model Chromophores: Excited-State Intra- and Intermolecular Proton Transfer. , 2014, The journal of physical chemistry letters.

[8]  Gregory F Payne,et al.  Context-dependent redox properties of natural phenolic materials. , 2014, Biomacromolecules.

[9]  G. Vitiello,et al.  Red human hair pheomelanin is a potent pro‐oxidant mediating UV‐independent contributory mechanisms of melanomagenesis , 2014, Pigment cell & melanoma research.

[10]  G. D’Errico,et al.  Atypical structural and π-electron features of a melanin polymer that lead to superior free-radical-scavenging properties. , 2013, Angewandte Chemie.

[11]  K. Wakamatsu,et al.  Raman spectroscopy as a non‐invasive technique for the quantification of melanins in feathers and hairs , 2013, Pigment cell & melanoma research.

[12]  J. Lo,et al.  How does pheomelanin synthesis contribute to melanomagenesis? , 2013, BioEssays : news and reviews in molecular, cellular and developmental biology.

[13]  S. Iannotta,et al.  Irreversible evolution of eumelanin redox states detected by an organic electrochemical transistor: en route to bioelectronics and biosensing. , 2013, Journal of materials chemistry. B.

[14]  Dean P. Jones,et al.  The Redox Proteome* , 2013, The Journal of Biological Chemistry.

[15]  K. Wakamatsu,et al.  Vibrational characterization of pheomelanin and trichochrome F by Raman spectroscopy. , 2013, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[16]  L. Flohé The fairytale of the GSSG/GSH redox potential. , 2013, Biochimica et biophysica acta.

[17]  Lucia Panzella,et al.  Red hair benzothiazines and benzothiazoles: mutation-inspired chemistry in the quest for functionality. , 2013, Accounts of chemical research.

[18]  W. Bentley,et al.  Reverse engineering to suggest biologically relevant redox activities of phenolic materials. , 2013, ACS chemical biology.

[19]  M. Herlyn,et al.  Cancer: Complexion matters , 2012, Nature.

[20]  Graeme R. Hanson,et al.  Role of semiconductivity and ion transport in the electrical conduction of melanin , 2012, Proceedings of the National Academy of Sciences.

[21]  K. Wakamatsu,et al.  Diversity of human hair pigmentation as studied by chemical analysis of eumelanin and pheomelanin , 2011, Journal of the European Academy of Dermatology and Venereology : JEADV.

[22]  G. Greco,et al.  A melanin-inspired pro-oxidant system for dopa(mine) polymerization: mimicking the natural casing process. , 2011, Chemical communications.

[23]  M. Brilliant,et al.  Usefulness of alkaline hydrogen peroxide oxidation to analyze eumelanin and pheomelanin in various tissue samples: application to chemical analysis of human hair melanins , 2011, Pigment cell & melanoma research.

[24]  Eunkyoung Kim,et al.  Redox-cycling and H2O2 generation by fabricated catecholic films in the absence of enzymes. , 2011, Biomacromolecules.

[25]  D. Whiteman,et al.  Estimating the attributable fraction for melanoma: A meta‐analysis of pigmentary characteristics and freckling , 2010, International journal of cancer.

[26]  Lucia Panzella,et al.  Zinc‐induced Structural Effects Enhance Oxygen Consumption and Superoxide Generation in Synthetic Pheomelanins on UVA/Visible Light Irradiation † , 2010, Photochemistry and photobiology.

[27]  K. Wakamatsu,et al.  Chemical analysis of late stages of pheomelanogenesis: conversion of dihydrobenzothiazine to a benzothiazole structure , 2009, Pigment cell & melanoma research.

[28]  Robert Langer,et al.  Biocompatibility of biodegradable semiconducting melanin films for nerve tissue engineering. , 2009, Biomaterials.

[29]  T. Sarna,et al.  Chemical and structural diversity in eumelanins: unexplored bio-optoelectronic materials. , 2009, Angewandte Chemie.

[30]  E. Zamir,et al.  Reverse engineering intracellular biochemical networks. , 2008, Nature chemical biology.

[31]  Nicholas T. Ingolia,et al.  Systems biology: Reverse engineering the cell , 2008, Nature.

[32]  M. Bennett,et al.  Metabolic gene regulation in a dynamically changing environment , 2008, Nature.

[33]  Dean P. Jones,et al.  Nonequilibrium thermodynamics of thiol/disulfide redox systems: a perspective on redox systems biology. , 2008, Free radical biology & medicine.

[34]  Jerome T. Mettetal,et al.  The Frequency Dependence of Osmo-Adaptation in Saccharomyces cerevisiae , 2008, Science.

[35]  K. Wakamatsu,et al.  Regulation of human skin pigmentation and responses to ultraviolet radiation. , 2007, Pigment cell research.

[36]  V. Barone,et al.  Short-lived quinonoid species from 5,6-dihydroxyindole dimers en route to eumelanin polymers: integrated chemical, pulse radiolytic, and quantum mechanical investigation. , 2006, Journal of the American Chemical Society.

[37]  G. Edwards,et al.  The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface , 2006, Proceedings of the National Academy of Sciences.

[38]  S. Ito Encapsulation of a reactive core in neuromelanin , 2006, Proceedings of the National Academy of Sciences.

[39]  Glenn S Edwards,et al.  Photoionization Thresholds of Melanins Obtained from Free Electron Laser–Photoelectron Emission Microscopy, Femtosecond Transient Absorption Spectroscopy and Electron Paramagnetic Resonance Measurements of Oxygen Photoconsumption , 2006, Photochemistry and photobiology.

[40]  Claire J Tomlin,et al.  Understanding biology by reverse engineering the control. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[41]  Ovidiu Lipan,et al.  The use of oscillatory signals in the study of genetic networks. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[42]  John C. Doyle,et al.  Surviving heat shock: control strategies for robustness and performance. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[43]  T. McIntire,et al.  Effect of stacking and redox state on optical absorption spectra of melanins -- comparison of theoretical and experimental results. , 2005, The journal of physical chemistry. B.

[44]  Haishan Zeng,et al.  Raman spectroscopy of in vivo cutaneous melanin. , 2004, Journal of biomedical optics.

[45]  K. Wakamatsu,et al.  Advanced chemical methods in melanin determination. , 2002, Pigment cell research.

[46]  P. Farmer,et al.  Redox behavior of melanins: direct electrochemistry of dihydroxyindole-melanin and its Cu and Zn adducts. , 2002, Journal of inorganic biochemistry.

[47]  E. Jacobson Pathogenic roles for fungal melanins. , 2000, Clinical microbiology reviews.

[48]  E. Jacobson,et al.  Redox buffering by melanin and Fe(II) in Cryptococcus neoformans , 1997, Journal of bacteriology.

[49]  G. Dryhurst,et al.  Oxidation of dopamine in the presence of cysteine: characterization of new toxic products. , 1997, Chemical research in toxicology.

[50]  B. Xia,et al.  Synthesis, redox properties, in vivo formation, and neurobehavioral effects of N-acetylcysteinyl conjugates of dopamine: possible metabolites of relevance to Parkinson's disease. , 1996, Chemical research in toxicology.

[51]  G. Dryhurst,et al.  Oxidation chemistry of (-)-norepinephrine in the presence of L-cysteine. , 1996, Journal of medicinal chemistry.

[52]  A. Napolitano,et al.  Oxidative Polymerization of the Pheomelanin Precursor 5-Hydroxy-1,4-benzothiazinylalanine: A New Hint to the Pigment Structure. , 1996, The Journal of organic chemistry.

[53]  K. Wakamatsu,et al.  Pheomelanin as well as eumelanin is present in human epidermis. , 1991, The Journal of investigative dermatology.

[54]  S. Ito Reexamination of the structure of eumelanin. , 1986, Biochimica et biophysica acta.

[55]  T. Sarna,et al.  PHOTOSENSITIZATION OF MELANINS: A COMPARATIVE STUDY , 1985, Photochemistry and Photobiology.

[56]  T. Sarna,et al.  Free radicals from eumelanins: quantum yields and wavelength dependence. , 1984, Archives of biochemistry and biophysics.

[57]  J. S. Hyde,et al.  Novel free radicals in synthetic and natural pheomelanins: distinction between dopa melanins and cysteinyldopa melanins by ESR spectroscopy. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[58]  J McGinness,et al.  Amorphous Semiconductor Switching in Melanins , 1974, Science.

[59]  Jochen K. Lennerz,et al.  An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair / fair skin background , 2012 .

[60]  R. Schwarzenbach,et al.  Novel electrochemical approach to assess the redox properties of humic substances. , 2010, Environmental science & technology.

[61]  J. Kayser-Jones Comparative Study , 2006 .

[62]  G. Edwards,et al.  Oxidation Potentials of Human Eumelanosomes and Pheomelanosomes¶ , 2005, Photochemistry and photobiology.

[63]  L. Berliner,et al.  Free radicals, metals, medicine, and physiology , 2005 .

[64]  T. Sarna,et al.  Biophysical Studies of Melanin , 2005 .