Snake venom toxin from Vipera lebetina turanica sensitizes cancer cells to TRAIL through ROS- and JNK-mediated upregulation of death receptors and downregulation of survival proteins

[1]  J. Hong,et al.  Snake venom toxin from vipera lebetina turanica induces apoptosis of colon cancer cells via upregulation of ROS- and JNK-mediated death receptor expression , 2012, BMC Cancer.

[2]  B. Aggarwal,et al.  Cardamonin sensitizes tumour cells to TRAIL through ROS‐ and CHOP‐mediated up‐regulation of death receptors and down‐regulation of survival proteins , 2012, British journal of pharmacology.

[3]  J. Hong,et al.  Anti-cancer effect of bee venom toxin and melittin in ovarian cancer cells through induction of death receptors and inhibition of JAK2/STAT3 pathway. , 2012, Toxicology and applied pharmacology.

[4]  H. Wajant,et al.  TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms , 2011, Cell Death and Disease.

[5]  P. Oliver,et al.  Combined modality therapy with TRAIL or agonistic death receptor antibodies , 2011, Cancer biology & therapy.

[6]  A. Taly,et al.  From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules , 2011, Toxins.

[7]  B. Aggarwal,et al.  ROS and CHOP are critical for dibenzylideneacetone to sensitize tumor cells to TRAIL through induction of death receptors and downregulation of cell survival proteins. , 2011, Cancer research.

[8]  F. Khuri,et al.  c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL , 2010, Molecular Cancer.

[9]  B. Aggarwal,et al.  Gossypol Induces Death Receptor-5 through Activation of the ROS-ERK-CHOP Pathway and Sensitizes Colon Cancer Cells to TRAIL* , 2010, The Journal of Biological Chemistry.

[10]  S. de Jong,et al.  Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer. , 2010, Biochimica et Biophysica Acta.

[11]  B. Aggarwal,et al.  Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins , 2010, Molecular Cancer Therapeutics.

[12]  Yung-Hyun Choi,et al.  β-Ionone Enhances TRAIL-Induced Apoptosis in Hepatocellular Carcinoma Cells through Sp1-Dependent Upregulation of DR5 and Downregulation of NF-κB Activity , 2010, Molecular Cancer Therapeutics.

[13]  Jeonghoon Heo,et al.  Quercetin enhances TRAIL-induced apoptosis in prostate cancer cells via increased protein stability of death receptor 5. , 2010, Life sciences.

[14]  B. G. Sanders,et al.  Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling , 2010, Breast Cancer Research and Treatment.

[15]  B. Aggarwal,et al.  Celastrol, a Triterpene, Enhances TRAIL-induced Apoptosis through the Down-regulation of Cell Survival Proteins and Up-regulation of Death Receptors* , 2010, The Journal of Biological Chemistry.

[16]  J. Hong,et al.  Snake venom toxin inhibits cell growth through induction of apoptosis in neuroblastoma cells , 2009, Archives of pharmacal research.

[17]  Patrizia Russo,et al.  Foundation review : a 7-Nicotinic receptor antagonists at the beginning of a clinical era for NSCLC and Mesothelioma ? , 2009 .

[18]  B. Aggarwal,et al.  Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species. , 2009, Cancer research.

[19]  A. Thorburn,et al.  EGFR-targeted diphtheria toxin stimulates TRAIL killing of glioblastoma cells by depleting anti-apoptotic proteins , 2009, Journal of Neuro-Oncology.

[20]  Taoyong Chen,et al.  Melittin, a Major Component of Bee Venom, Sensitizes Human Hepatocellular Carcinoma Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis by Activating CaMKII-TAK1-JNK/p38 and Inhibiting IκBα Kinase-NFκB* , 2009, Journal of Biological Chemistry.

[21]  谷口 浩也.  Baicalein overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells , 2009 .

[22]  Mark J. Smyth,et al.  The TRAIL apoptotic pathway in cancer onset, progression and therapy , 2008, Nature Reviews Cancer.

[23]  Wan-Wan Lin,et al.  15-deoxy-Δ12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription , 2008, Molecular Cancer Therapeutics.

[24]  S. Hsu,et al.  Honeybee venom induces calcium-dependent but caspase-independent apoptotic cell death in human melanoma A2058 cells. , 2008, Toxicon : official journal of the International Society on Toxinology.

[25]  R. Herbst,et al.  To kill a tumor cell: the potential of proapoptotic receptor agonists. , 2008, The Journal of clinical investigation.

[26]  D. Lee,et al.  Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway. , 2008, Biochemical pharmacology.

[27]  Jai-Sing Yang,et al.  The role of mitochondria in bee venom-induced apoptosis in human breast cancer MCF7 cells. , 2008, In vivo.

[28]  Y. Utkin,et al.  Viperidae snake venoms block nicotinic acetylcholine receptors and voltage-gated Ca2+ channels in identified neurons of fresh-water snail Lymnaea stagnalis , 2008, Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology.

[29]  A. Thorburn,et al.  Tumor-derived Mutations in the TRAIL Receptor DR5 Inhibit TRAIL Signaling through the DR4 Receptor by Competing for Ligand Binding* , 2007, Journal of Biological Chemistry.

[30]  L. Andĕra,et al.  Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts , 2007, Molecular Cancer Therapeutics.

[31]  S. Pervaiz,et al.  LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization , 2007, Cell Death and Differentiation.

[32]  M. Lavin,et al.  The Diversity of Bioactive Proteins in Australian Snake Venoms*S , 2007, Molecular & Cellular Proteomics.

[33]  J. Eberle,et al.  Apoptosis pathways as promising targets for skin cancer therapy , 2007, The British journal of dermatology.

[34]  Ronald Koschny,et al.  The promise of TRAIL—potential and risks of a novel anticancer therapy , 2007, Journal of Molecular Medicine.

[35]  Jae Woong Lee,et al.  Inhibitory effect of snake venom toxin from Vipera lebetina turanica on hormone-refractory human prostate cancer cell growth: induction of apoptosis through inactivation of nuclear factor κB , 2007, Molecular Cancer Therapeutics.

[36]  T. Kwon,et al.  Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5. , 2006, Cancer research.

[37]  Jong-Wook Park,et al.  Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5). , 2005, Carcinogenesis.

[38]  R. Maroun,et al.  Snake venom serine proteinases: sequence homology vs. substrate specificity, a paradox to be solved. , 2005, Toxicon : official journal of the International Society on Toxinology.

[39]  W. Wu,et al.  The Modulating Role of Nuclear Factor-κB in the Action of α7-Nicotinic Acetylcholine Receptor and Cross-Talk between 5-Lipoxygenase and Cyclooxygenase-2 in Colon Cancer Growth Induced by 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone , 2004, Journal of Pharmacology and Experimental Therapeutics.

[40]  Wafik S El-Deiry,et al.  TRAIL and apoptosis induction by TNF-family death receptors , 2003, Oncogene.

[41]  R. Lewis,et al.  Therapeutic potential of venom peptides , 2003, Nature Reviews Drug Discovery.

[42]  T. Zhou,et al.  Bisindolylmaleimide VIII Enhances DR5-mediated Apoptosis through the MKK4/JNK/p38 Kinase and the Mitochondrial Pathways* , 2002, The Journal of Biological Chemistry.

[43]  L. Corcos,et al.  Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis. , 2001, Cancer research.

[44]  M. Shin,et al.  Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphoma , 2001, Oncogene.

[45]  M. Willingham,et al.  Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor and Ara-C exert synergistic toxicity against human AML HL-60 cells. , 1999, Leukemia research.

[46]  M. Jäättelä,et al.  Escaping cell death: survival proteins in cancer. , 1999, Experimental cell research.

[47]  M. Nau,et al.  Chemotherapy augments TRAIL-induced apoptosis in breast cell lines. , 1999, Cancer research.