Single-walled carbon nanotubes in biomedical imaging

This article reviews the latest developments in using single-walled carbon nanotubes (SWNTs) for biomedical imaging. SWNTs with a number of unique intrinsic optical properties have been widely used as contrast agents in Raman imaging, near-infrared (NIR) fluorescence imaging and photoacoustic imaging in vitro and in vivo. More imaging functionalities including positron emission tomography (PET) and magnetic resonance (MR) imaging can be achieved by either utilizing external labels or the metal impurities of nanotube samples. Although there is still a long way to go before SWNTs are ready for clinical use, they are promising nanomaterials with great potential in multimodality biomedical imaging.

[1]  Malcolm L. H. Green,et al.  Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging. , 2010, Nature materials.

[2]  Adam de la Zerda,et al.  Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice. , 2010, Nano letters.

[3]  Zhuang Liu,et al.  Inorganic nanomaterials for tumor angiogenesis imaging , 2010, European Journal of Nuclear Medicine and Molecular Imaging.

[4]  Zhuang Liu,et al.  Multiplexed five-color molecular imaging of cancer cells and tumor tissues with carbon nanotube Raman tags in the near-infrared , 2010, Nano research.

[5]  Ardemis A. Boghossian,et al.  Detection of single-molecule H2O2 signaling from epidermal growth factor receptor using fluorescent single-walled carbon nanotubes , 2010, Nature nanotechnology.

[6]  Henri Szwarc,et al.  In vivo behavior of large doses of ultrashort and full-length single-walled carbon nanotubes after oral and intraperitoneal administration to Swiss mice. , 2010, ACS nano.

[7]  F. Zhao,et al.  Chemistry of carbon nanotubes in biomedical applications , 2010 .

[8]  Feng Liang,et al.  A review on biomedical applications of single-walled carbon nanotubes. , 2010, Current medicinal chemistry.

[9]  Thomas Kelly,et al.  In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells. , 2009, Nature nanotechnology.

[10]  Zhuang Liu,et al.  A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice. , 2009, Nature nanotechnology.

[11]  H. Choi,et al.  In vivo near-infrared mediated tumor destruction by photothermal effect of carbon nanotubes. , 2009, ACS Nano.

[12]  Stephen T. C. Wong,et al.  Single-Walled Carbon Nanotube Materials as T2-Weighted MRI Contrast Agents , 2009 .

[13]  V. Zharov,et al.  Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents. , 2009, Nature nanotechnology.

[14]  Zhuang Liu,et al.  Supramolecular stacking of doxorubicin on carbon nanotubes for in vivo cancer therapy. , 2009, Angewandte Chemie.

[15]  K Kostarelos,et al.  Promises, facts and challenges for carbon nanotubes in imaging and therapeutics. , 2009, Nature nanotechnology.

[16]  Lei Ding,et al.  Decoration of gold nanoparticles on surface-grown single-walled carbon nanotubes for detection of every nanotube by surface-enhanced Raman spectroscopy. , 2009, Journal of the American Chemical Society.

[17]  H. Dai,et al.  Preparation of carbon nanotube bioconjugates for biomedical applications , 2009, Nature Protocols.

[18]  M. Strano,et al.  The rational design of nitric oxide selectivity in single-walled carbon nanotube near-infrared fluorescence sensors for biological detection. , 2009, Nature chemistry.

[19]  D. Carroll,et al.  Increased Heating Efficiency and Selective Thermal Ablation of Malignant Tissue with DNA-Encased Multiwalled Carbon Nanotubes , 2009, ACS nano.

[20]  Yitao Ding,et al.  Cancer-cell targeting and photoacoustic therapy using carbon nanotubes as "bomb" agents. , 2009, Small.

[21]  H. Hong,et al.  Molecular Imaging with Single-Walled Carbon Nanotubes. , 2009, Nano today.

[22]  R. Weisman,et al.  In vivo therapeutic silencing of hypoxia-inducible factor 1 alpha (HIF-1α) using single-walled carbon nanotubes noncovalently coated with siRNA , 2009, Nano Reseach.

[23]  Feifan Zhou,et al.  Photoacoustic molecular imaging with antibody-functionalized single-walled carbon nanotubes for early diagnosis of tumor. , 2009, Journal of biomedical optics.

[24]  S. Gaillard,et al.  In vivo imaging of carbon nanotube biodistribution using magnetic resonance imaging. , 2009, Nano letters.

[25]  H. Dai,et al.  Carbon nanotubes in biology and medicine: In vitro and in vivo detection, imaging and drug delivery , 2009, Nano research.

[26]  Hongjie Dai,et al.  Protein microarrays with carbon nanotubes as multicolor Raman labels , 2008, Nature Biotechnology.

[27]  Hongjie Dai,et al.  Multiplexed multicolor Raman imaging of live cells with isotopically modified single walled carbon nanotubes. , 2008, Journal of the American Chemical Society.

[28]  H. Choi,et al.  Effect of nucleases on the cellular internalization of fluorescent labeled DNA-functionalized single-walled carbon nanotubes , 2008 .

[29]  Haifang Wang,et al.  Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice. , 2008, Toxicology letters.

[30]  John A. Rogers,et al.  Random networks and aligned arrays of single-walled carbon nanotubes for electronic device applications , 2008 .

[31]  Zhuang Liu,et al.  Carbon nanotubes as photoacoustic molecular imaging agents in living mice. , 2008, Nature nanotechnology.

[32]  Zhuang Liu,et al.  Drug delivery with carbon nanotubes for in vivo cancer treatment. , 2008, Cancer research.

[33]  M. Zheng,et al.  A DNA-based approach to the carbon nanotube sorting problem , 2008 .

[34]  S. Gambhir,et al.  Noninvasive Raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes. , 2008, Nano letters.

[35]  H. Dai,et al.  Complement activation by PEGylated single-walled carbon nanotubes is independent of C1q and alternative pathway turnover. , 2008, Molecular immunology.

[36]  Craig A. Poland,et al.  Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. , 2008, Nature nanotechnology.

[37]  Austin D. Swafford,et al.  Thermal ablation of tumor cells with antibody-functionalized single-walled carbon nanotubes , 2008, Proceedings of the National Academy of Sciences.

[38]  Carolyn R Bertozzi,et al.  Biocompatible carbon nanotubes generated by functionalization with glycodendrimers. , 2008, Angewandte Chemie.

[39]  Michael S Strano,et al.  Single-particle tracking of endocytosis and exocytosis of single-walled carbon nanotubes in NIH-3T3 cells. , 2008, Nano letters.

[40]  S. Gambhir,et al.  Noninvasive molecular imaging of small living subjects using Raman spectroscopy , 2008, Proceedings of the National Academy of Sciences.

[41]  Sanjiv S Gambhir,et al.  A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice. , 2008, Nature nanotechnology.

[42]  Weibo Cai,et al.  Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy , 2008, Proceedings of the National Academy of Sciences.

[43]  Haifang Wang,et al.  A generally adoptable radiotracing method for tracking carbon nanotubes in animals , 2008, Nanotechnology.

[44]  Ande Bao,et al.  Dynamic Imaging of Functionalized Multi‐Walled Carbon Nanotube Systemic Circulation and Urinary Excretion , 2008 .

[45]  Zhuang Liu,et al.  Selective probing and imaging of cells with single walled carbon nanotubes as near-infrared fluorescent molecules. , 2008, Nano letters.

[46]  Daniel Scherman,et al.  Noncovalent functionalization of carbon nanotubes with amphiphilic gd3+ chelates: toward powerful t1 and t2 MRI contrast agents. , 2008, Nano letters.

[47]  H. Dai,et al.  In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. , 2020, Nature nanotechnology.

[48]  Filip Braet,et al.  Carbon nanotubes for biological and biomedical applications , 2007 .

[49]  Michael S. Shur,et al.  Recent advances in application of acoustic, acousto‐optic and photoacoustic methods in biology and medicine , 2007 .

[50]  D. Scheinberg,et al.  PET Imaging of Soluble Yttrium-86-Labeled Carbon Nanotubes in Mice , 2007, PloS one.

[51]  R. Weisman,et al.  Single-walled carbon nanotubes in the intact organism: near-IR imaging and biocompatibility studies in Drosophila. , 2007, Nano letters.

[52]  Hongjie Dai,et al.  Supramolecular Chemistry on Water- Soluble Carbon Nanotubes for Drug Loading and Delivery , 2007 .

[53]  D. Scheinberg,et al.  Tumor Targeting with Antibody-Functionalized, Radiolabeled Carbon Nanotubes , 2007, Journal of Nuclear Medicine.

[54]  Shuming Nie,et al.  Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry , 2007, Nature Protocols.

[55]  Hongjie Dai,et al.  siRNA delivery into human T cells and primary cells with carbon-nanotube transporters. , 2007, Angewandte Chemie.

[56]  Freddy T. Nguyen,et al.  Multimodal biomedical imaging with asymmetric single-walled carbon nanotube/iron oxide nanoparticle complexes. , 2007, Nano letters.

[57]  T. Pichler,et al.  Isotope-Engineered Single-Wall Carbon Nanotubes; A Key Material for Magnetic Studies , 2007 .

[58]  M. Prato,et al.  Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. , 2007, Nature nanotechnology.

[59]  Steven A Curley,et al.  Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence , 2006, Proceedings of the National Academy of Sciences.

[60]  M. Prato,et al.  Carbon nanotubes as nanomedicines: from toxicology to pharmacology. , 2006, Advanced drug delivery reviews.

[61]  Carolyn R Bertozzi,et al.  Interfacing carbon nanotubes with living cells. , 2006, Journal of the American Chemical Society.

[62]  Maurizio Prato,et al.  Double functionalization of carbon nanotubes for multimodal drug delivery. , 2006, Chemical communications.

[63]  M. Prato,et al.  Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[64]  Thomas E. Eurell,et al.  Single‐Walled Carbon Nanotube Spectroscopy in Live Cells: Towards Long‐Term Labels and Optical Sensors , 2005 .

[65]  Tsukasa Akasaka,et al.  Oxidation of multiwalled carbon nanotubes by nitric acid , 2005 .

[66]  M. Prato,et al.  Applications of carbon nanotubes in drug delivery. , 2005, Current opinion in chemical biology.

[67]  Michael S Strano,et al.  In vivo fluorescence detection of glucose using a single-walled carbon nanotube optical sensor: design, fluorophore properties, advantages, and disadvantages. , 2005, Analytical chemistry.

[68]  Zhuang Liu,et al.  Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing. , 2005, Journal of the American Chemical Society.

[69]  H. Dai,et al.  Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[70]  K. Leong,et al.  Polyethylenimine-grafted multiwalled carbon nanotubes for secure noncovalent immobilization and efficient delivery of DNA. , 2005, Angewandte Chemie.

[71]  M. Prato,et al.  Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: toward the construction of nanotube-based gene delivery vectors. , 2005, Journal of the American Chemical Society.

[72]  H. Dai,et al.  Carbon nanotubes as intracellular protein transporters: generality and biological functionality. , 2005, Journal of the American Chemical Society.

[73]  M. Prato,et al.  Biomedical applications of functionalised carbon nanotubes. , 2005, Chemical communications.

[74]  S. Bachilo,et al.  Near-infrared fluorescence microscopy of single-walled carbon nanotubes in phagocytic cells. , 2004, Journal of the American Chemical Society.

[75]  Z. Gu,et al.  Biodistribution of carbon single-wall carbon nanotubes in mice. , 2004, Journal of nanoscience and nanotechnology.

[76]  M. Prato,et al.  Functionalized carbon nanotubes for plasmid DNA gene delivery. , 2004, Angewandte Chemie.

[77]  É. Duguet,et al.  Magnetic nanoparticle design for medical diagnosis and therapy , 2004 .

[78]  H. Dai,et al.  Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells. , 2004, Journal of the American Chemical Society.

[79]  Maurizio Prato,et al.  Functionalization of carbon nanotubes via 1,3-dipolar cycloadditions , 2004 .

[80]  J. James,et al.  Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. , 2003, Toxicological sciences : an official journal of the Society of Toxicology.

[81]  T. Webb,et al.  Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. , 2003, Toxicological sciences : an official journal of the Society of Toxicology.

[82]  Riichiro Saito,et al.  Characterizing carbon nanotube samples with resonance Raman scattering , 2003 .

[83]  M. Lundstrom,et al.  Ballistic carbon nanotube field-effect transistors , 2003, Nature.

[84]  T. Ebbesen,et al.  Supramolecular Self-Assembly of Lipid Derivatives on Carbon Nanotubes , 2003, Science.

[85]  M. Zheng,et al.  DNA-assisted dispersion and separation of carbon nanotubes , 2003, Nature materials.

[86]  M. Prato,et al.  Synthesis, structural characterization, and immunological properties of carbon nanotubes functionalized with peptides. , 2003, Journal of the American Chemical Society.

[87]  M. Shim,et al.  Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[88]  Quan Qing,et al.  Effect of Chemical Oxidation on the Structure of Single-Walled Carbon Nanotubes , 2003 .

[89]  C. Mirkin,et al.  Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection. , 2002, Science.

[90]  Hongjie Dai,et al.  Carbon nanotubes: synthesis, integration, and properties. , 2002, Accounts of chemical research.

[91]  V. C. Moore,et al.  Band Gap Fluorescence from Individual Single-Walled Carbon Nanotubes , 2002, Science.

[92]  J. Tour,et al.  Covalent chemistry of single-wall carbon nanotubes , 2002 .

[93]  A. Hirsch.  Functionalization of single-walled carbon nanotubes. , 2002, Angewandte Chemie.

[94]  M. Prato,et al.  Organic functionalization of carbon nanotubes. , 2002, Journal of the American Chemical Society.

[95]  S. Fan,et al.  Isotope labeling of carbon nanotubes and formation of (12)C-(13)C nanotube junctions. , 2001, Journal of the American Chemical Society.

[96]  H. Dai,et al.  Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization. , 2001, Journal of the American Chemical Society.

[97]  Richard H. Friend,et al.  Composites of Carbon Nanotubes and Conjugated Polymers for Photovoltaic Devices , 1999 .

[98]  R. Brooks,et al.  Relaxometry and magnetometry of the MR contrast agent MION‐46L , 1999, Magnetic resonance in medicine.

[99]  H. Dai,et al.  Self-oriented regular arrays of carbon nanotubes and their field emission properties , 1999, Science.

[100]  A. Rinzler,et al.  Electronic structure of atomically resolved carbon nanotubes , 1998, Nature.

[101]  H. Dai,et al.  Individual single-wall carbon nanotubes as quantum wires , 1997, Nature.

[102]  D. Bethune,et al.  Storage of hydrogen in single-walled carbon nanotubes , 1997, Nature.

[103]  A. M. Rao,et al.  Diameter-Selective Raman Scattering from Vibrational Modes in Carbon Nanotubes , 1997, Science.

[104]  P. Jacobs,et al.  Physical and chemical properties of superparamagnetic iron oxide MR contrast agents: ferumoxides, ferumoxtran, ferumoxsil. , 1995, Magnetic resonance imaging.

[105]  S. Iijima.  Helical microtubules of graphitic carbon , 1991, Nature.

[106]  J. Aubin.  Autofluorescence of viable cultured mammalian cells. , 1979, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.