Structural enzymology of polyketide synthases.
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[1] S. Larsen,et al. The X‐ray crystal structure of β‐ketoacyl [acyl carrier protein] synthase I , 1999 .
[2] D. Cane,et al. Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase. , 2005, Journal of the American Chemical Society.
[3] Jie J. Zheng,et al. The structural biology of type II fatty acid biosynthesis. , 2005, Annual review of biochemistry.
[4] Collaborative Computational,et al. The CCP4 suite: programs for protein crystallography. , 1994, Acta crystallographica. Section D, Biological crystallography.
[5] C. Khosla,et al. Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[6] C. Dempsey,et al. Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2). , 1997, Biochemistry.
[7] B. Chakravarty,et al. Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[8] J. Thornton,et al. PROCHECK: a program to check the stereochemical quality of protein structures , 1993 .
[9] R J Read,et al. Crystallography & NMR system: A new software suite for macromolecular structure determination. , 1998, Acta crystallographica. Section D, Biological crystallography.
[10] Alexander McPherson,et al. Introduction to protein crystallization. , 2004, Methods.
[11] A. Keatinge-Clay,et al. A tylosin ketoreductase reveals how chirality is determined in polyketides. , 2007, Chemistry & biology.
[12] Chaitan Khosla,et al. Structure and mechanism of the 6-deoxyerythronolide B synthase. , 2007, Annual review of biochemistry.
[13] D. Cane,et al. Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units. , 1999, Biochemistry.
[14] D. Cane,et al. Substrate specificity of the loading didomain of the erythromycin polyketide synthase. , 2000, Biochemistry.
[15] C. Khosla,et al. Heterologous expression, purification, reconstitution and kinetic analysis of an extended type II polyketide synthase. , 1999, Chemistry & biology.
[16] Adrian Keatinge-Clay,et al. Crystal structure of the erythromycin polyketide synthase dehydratase. , 2008, Journal of molecular biology.
[17] D. Cane,et al. Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase. , 2002, Biochemistry.
[18] J. Wong,et al. Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase. , 2008, Biochemistry.
[19] Thomas Terwilliger,et al. SOLVE and RESOLVE: automated structure solution, density modification and model building. , 2004, Journal of synchrotron radiation.
[20] C Richard Hutchinson,et al. A model of structure and catalysis for ketoreductase domains in modular polyketide synthases. , 2003, Biochemistry.
[21] P. Leadlay,et al. High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase. , 2006, Chemistry & biology.
[22] M. Marahiel,et al. Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE. , 2002, Structure.
[23] I. Rayment,et al. Structural and Functional Analysis of Tetracenomycin F2 Cyclase from Streptomyces glaucescens , 2004, Journal of Biological Chemistry.
[24] Bainan Wu,et al. Key Residues Responsible for Acyl Carrier Protein and β-Ketoacyl-Acyl Carrier Protein Reductase (FabG) Interaction* , 2003, Journal of Biological Chemistry.
[25] Alex Bateman,et al. The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases , 2004, BMC Bioinformatics.
[26] C. Walsh,et al. Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase , 2008, Nature.
[27] L. Miercke,et al. Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[28] Katalin F Medzihradszky,et al. An antibiotic factory caught in action , 2004, Nature Structural &Molecular Biology.
[29] A. Joshi,et al. Construction, expression, and characterization of a mutated animal fatty acid synthase deficient in the dehydrase function. , 1993, The Journal of biological chemistry.
[30] A. Witkowski,et al. Mechanism of the β-Ketoacyl Synthase Reaction Catalyzed by the Animal Fatty Acid Synthase† , 2002 .
[31] D. Cane,et al. Dissecting and exploiting intermodular communication in polyketide synthases. , 1999, Science.
[32] C. Khosla,et al. Cloning, Nucleotide Sequence, and Heterologous Expression of the Biosynthetic Gene Cluster for R1128, a Non-steroidal Estrogen Receptor Antagonist , 2000, The Journal of Biological Chemistry.
[33] Joseph P Noel,et al. The chalcone synthase superfamily of type III polyketide synthases. , 2003, Natural product reports.
[34] B. Moore,et al. Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreduction. , 2004, Chemistry & biology.
[35] Robert M Stroud,et al. The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases. , 2006, Structure.
[36] Chu-Young Kim,et al. Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase. , 2006, Journal of the American Chemical Society.
[37] P. Leadlay,et al. Stereochemistry of catalysis by the ketoreductase activity in the first extension module of the erythromycin polyketide synthase. , 2002, Biochemistry.
[38] C. Khosla,et al. Malonyl-CoA:ACP transacylase from Streptomyces coelicolor has two alternative catalytically active nucleophiles. , 2001, Biochemistry.
[39] A. Witkowski,et al. Characterization of the beta-carbon processing reactions of the mammalian cytosolic fatty acid synthase: role of the central core. , 2004, Biochemistry.
[40] M. Degano,et al. Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier. , 2003, Journal of molecular biology.
[41] W. Somers,et al. Automated systems for protein crystallization. , 2004, Methods.
[42] Chaitan Khosla,et al. Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. , 2003, Structure.
[43] Yuemao Shen,et al. Engineered biosynthesis of novel polyketides from Streptomyces spore pigment polyketide synthases , 1998 .
[44] M. Reed,et al. The type I rat fatty acid synthase ACP shows structural homology and analogous biochemical properties to type II ACPs. , 2003, Organic & biomolecular chemistry.
[45] Shiou-Chuan Tsai,et al. Polyketide chain length control by chain length factor. , 2003, Journal of the American Chemical Society.
[46] P. Lackner,et al. The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands , 2008, BMC Evolutionary Biology.
[47] R. Thomas. A Biosynthetic Classification of Fungal and Streptomycete Fused‐Ring Aromatic Polyketides , 2001, Chembiochem : a European journal of chemical biology.
[48] M. Marahiel,et al. The thioesterase domain of the fengycin biosynthesis cluster: a structural base for the macrocyclization of a non-ribosomal lipopeptide. , 2006, Journal of molecular biology.
[49] C. Townsend,et al. Starter unit specificity directs genome mining of polyketide synthase pathways in fungi. , 2008, Bioorganic chemistry.
[50] Zbigniew Dauter,et al. Crystal structure of the Escherichia coli thioesterase II, a homolog of the human Nef binding enzyme , 2000, Nature Structural Biology.
[51] C. Rock,et al. The 1.3-Angstrom-Resolution Crystal Structure of β-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae , 2003, Journal of bacteriology.
[52] James Z. Chadick,et al. Structure and molecular organization of mammalian fatty acid synthase , 2005, Nature Structural &Molecular Biology.
[53] Chaitan Khosla,et al. Solution structure and proposed domain–domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase , 2007, Protein science : a publication of the Protein Society.
[54] Z Dauter,et al. The Escherichia coli Malonyl-CoA:Acyl Carrier Protein Transacylase at 1.5-Å Resolution. , 1995, The Journal of Biological Chemistry.
[55] D. O'Hagan. Biosynthesis of fatty acid and polyketide metabolites. , 1993, Natural product reports.
[56] Chaitan Khosla,et al. Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits , 1995, Nature.
[57] Gitanjali Yadav,et al. Computational approach for prediction of domain organization and substrate specificity of modular polyketide synthases. , 2003, Journal of molecular biology.
[58] C. Redfield,et al. Using nuclear magnetic resonance spectroscopy to study molten globule states of proteins. , 2004, Methods.
[59] Y. Kallberg,et al. Coenzyme-based functional assignments of short-chain dehydrogenases/reductases (SDRs). , 2003, Chemico-biological interactions.
[60] J. L. Smith,et al. Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site. , 1996, Structure.
[61] K. Ishida,et al. Orchestration of discoid polyketide cyclization in the resistomycin pathway. , 2008, Journal of the American Chemical Society.
[62] Patrick Caffrey,et al. Conserved Amino Acid Residues Correlating With Ketoreductase Stereospecificity in Modular Polyketide Synthases , 2003, Chembiochem : a European journal of chemical biology.
[63] Kira J Weissman,et al. The Structural Basis for Docking in Modular Polyketide Biosynthesis , 2006, Chembiochem : a European journal of chemical biology.
[64] C. Rock,et al. Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG. , 2004, Structure.
[65] Kevin Cowtan,et al. research papers Acta Crystallographica Section D Biological , 2005 .
[66] D. Hopwood,et al. Genetic Contributions to Understanding Polyketide Synthases. , 1997, Chemical reviews.
[67] Wenjun Zhang,et al. Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli , 2008, Proceedings of the National Academy of Sciences.
[68] Janet L. Smith,et al. Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels , 2006, Nature chemical biology.
[69] R. Stroud,et al. Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. , 2002, Biochemistry.
[70] Mariusz Jaskolski,et al. Structure of a yellow lupin pathogenesis-related PR-10 protein belonging to a novel subclass. , 2005, Acta crystallographica. Section D, Biological crystallography.
[71] J. Balbach,et al. Protein folding studied by real-time NMR spectroscopy. , 2004, Methods.
[72] Timm Maier,et al. The Crystal Structure of a Mammalian Fatty Acid Synthase , 2008, Science.
[73] J. Pflugrath,et al. Macromolecular cryocrystallography--methods for cooling and mounting protein crystals at cryogenic temperatures. , 2004, Methods.
[74] P. Leadlay,et al. Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl‐CoA:acyl carrier protein transacylase domains in modular polyketide synthases , 1995, FEBS letters.
[75] C. Rock,et al. Structure of beta-ketoacyl-[acyl carrier protein] reductase from Escherichia coli: negative cooperativity and its structural basis. , 2001, Biochemistry.
[76] G. Schneider,et al. Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity. , 2006, Journal of molecular biology.
[77] Janet L. Smith,et al. Structural basis for macrolactonization by the pikromycin thioesterase , 2006, Nature chemical biology.
[78] Zygmunt S Derewenda,et al. The use of recombinant methods and molecular engineering in protein crystallization. , 2004, Methods.
[79] J. Hurley,et al. Structure and lipid transport mechanism of a StAR-related domain , 2000, Nature Structural Biology.
[80] A. Witkowski,et al. Mapping of functional interactions between domains of the animal fatty acid synthase by mutant complementation in vitro. , 1997, Biochemistry.
[81] Shiou-Chuan Tsai,et al. The type I fatty acid and polyketide synthases: a tale of two megasynthases. , 2007, Natural product reports.
[82] J. Staunton,et al. Active-site residue, domain and module swaps in modular polyketide synthases , 2003, Journal of Industrial Microbiology and Biotechnology.
[83] D. Otzen,et al. The Major Birch Allergen, Bet v 1, Shows Affinity for a Broad Spectrum of Physiological Ligands* , 2002, The Journal of Biological Chemistry.
[84] K. Fiebig,et al. The Structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Pseudomonas aeruginosa* , 2004, Journal of Biological Chemistry.
[85] Chu-Young Kim,et al. The 2.7-Å crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase , 2006 .
[86] S. Larsen,et al. CRYSTAL STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I FROM ESCHERICHIA COLI , 1999 .
[87] C R Hutchinson,et al. Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations. , 2001, Biochemistry.
[88] R. Heath,et al. Enoyl-Acyl Carrier Protein Reductase (fabI) Plays a Determinant Role in Completing Cycles of Fatty Acid Elongation in Escherichia coli(*) , 1995, The Journal of Biological Chemistry.
[89] Chaitan Khosla,et al. Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. , 2002, Structure.
[90] J R Jacobsen,et al. Tolerance and specificity of polyketide synthases. , 1999, Annual review of biochemistry.
[91] Flemming M. Poulsen,et al. X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy , 1996, Nature Structural Biology.
[92] Hui Hong,et al. Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion‐trap mass spectrometry , 2005, The FEBS journal.
[93] Daniel W. Udwary,et al. Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase , 2006, Proceedings of the National Academy of Sciences.
[94] Taek Soon Lee,et al. Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases , 2004, PLoS biology.
[95] C. Hutchinson,et al. Cloning and heterologous expression of a gene cluster for the biosynthesis of tetracenomycin C, the anthracycline antitumor antibiotic of Streptomyces glaucescens. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[96] C. Hutchinson,et al. Characterization of the enzymatic domains in the modular polyketide synthase involved in rifamycin B biosynthesis by Amycolatopsis mediterranei. , 1998, Gene.
[97] N. Ban,et al. The multienzyme architecture of eukaryotic fatty acid synthases. , 2008, Current opinion in structural biology.
[98] C. Méndez,et al. Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin. , 1996, Gene.
[99] P. Leadlay,et al. Stereospecific acyl transfers on the erythromycin-producing polyketide synthase. , 1994, Science.
[100] B. Moore,et al. Engineering biodiversity with type II polyketide synthase genes , 2000, Antonie van Leeuwenhoek.
[101] F. Asturias,et al. Head-to-head coiled arrangement of the subunits of the animal fatty acid synthase. , 2004, Chemistry & biology.
[102] N. Kelleher,et al. Deconstruction of Iterative Multidomain Polyketide Synthase Function , 2008, Science.
[103] Thanh Vu,et al. Crystal structure and functional analysis of tetracenomycin ARO/CYC: Implications for cyclization specificity of aromatic polyketides , 2008, Proceedings of the National Academy of Sciences.
[104] Shiou-Chuan Tsai,et al. Structural Analysis of Actinorhodin Polyketide Ketoreductase: Cofactor Binding and Substrate Specificity , 2004, Biochemistry.
[105] C. Khosla,et al. Building-block selectivity of polyketide synthases. , 2003, Current opinion in chemical biology.
[106] Chaitan Khosla,et al. Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein. , 2003, Biochemistry.
[107] C. Rock,et al. Roles of the Active Site Water, Histidine 303, and Phenylalanine 396 in the Catalytic Mechanism of the Elongation Condensing Enzyme of Streptococcus pneumoniae* , 2006, Journal of Biological Chemistry.
[108] A. Joshi,et al. Differential Affinity Labeling of the Two Subunits of the Homodimeric Animal Fatty Acid Synthase Allows Isolation of Heterodimers Consisting of Subunits That Have Been Independently Modified* , 1998, The Journal of Biological Chemistry.
[109] P. Vagelos,et al. The isolation and general properties of Escherichia coli malonyl coenzyme A-acyl carrier protein transacylase. , 1973, The Journal of biological chemistry.
[110] John Crosby,et al. Solution structure and dynamics of oxytetracycline polyketide synthase acyl carrier protein from Streptomyces rimosus. , 2003, Biochemistry.
[111] P. Leadlay,et al. Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase. , 2006, Chemistry & biology.
[112] C. Khosla,et al. Domain Analysis of the Molecular Recognition Features of Aromatic Polyketide Synthase Subunits* , 1997, The Journal of Biological Chemistry.
[113] D. Cane,et al. Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases. , 2003, Biochemistry.
[114] John Crosby,et al. The crystal structure of the actIII actinorhodin polyketide reductase: proposed mechanism for ACP and polyketide binding. , 2004, Structure.
[115] Daniel W. Udwary,et al. A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase. , 2002, Journal of molecular biology.
[116] Chu-Young Kim,et al. Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase. , 2007, Chemistry & biology.
[117] S. Burston,et al. An ACP Structural Switch: Conformational Differences between the Apo and Holo Forms of the Actinorhodin Polyketide Synthase Acyl Carrier Protein , 2008, Chembiochem : a European journal of chemical biology.
[118] J. Bailey,et al. Engineered Biosynthesis of Novel Polyketides: Properties of the whiE Aromatase/Cyclase , 1996, Nature Biotechnology.
[119] E. Koonin,et al. Adaptations of the helix‐grip fold for ligand binding and catalysis in the START domain superfamily , 2001, Proteins.
[120] Gunter Schneider,et al. Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation , 2004, The EMBO journal.
[121] Timm Maier,et al. Architecture of Mammalian Fatty Acid Synthase at 4.5 Å Resolution , 2006, Science.
[122] Stuart Smith,et al. Alteration of the Substrate Specificity of the Malonyl-CoA/Acetyl-CoA:Acyl Carrier ProteinS-Acyltransferase Domain of the Multifunctional Fatty Acid Synthase by Mutation of a Single Arginine Residue* , 1997, The Journal of Biological Chemistry.
[123] Ben Shen,et al. Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms. , 2003, Current opinion in chemical biology.
[124] Junwen Wang,et al. Predictive models for protein crystallization. , 2004, Methods.
[125] John Crosby,et al. Kinetic and mechanistic analysis of the malonyl CoA:ACP transacylase from Streptomyces coelicolor indicates a single catalytically competent serine nucleophile at the active site. , 2002, Biochemistry.
[126] B. Shen,et al. Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase. , 1996, Proceedings of the National Academy of Sciences of the United States of America.