Study of Microbial Evolution through Loss of Biosynthetic Functions: Establishment of “Defective” Mutants

On appropriate media, mutants which have lost a biosynthetic function may exhibit a selective advantage over parental strains. Is this how “parasitism” became established ?

[1]  L. K. Schneider,et al.  THE CONSEQUENCES OF MUTATION DURING THE GROWTH OF BIOCHEMICAL MUTANTS OF ESCHERICHIA COLI IV , 1949, Journal of bacteriology.

[2]  S. Benzer,et al.  The nature of the "deletion" mutants in the rII region of phage T4. , 1961, Journal of molecular biology.

[3]  J. Spizizen,et al.  TRANSFORMATION OF BIOCHEMICALLY DEFICIENT STRAINS OF BACILLUS SUBTILIS BY DEOXYRIBONUCLEATE. , 1958, Proceedings of the National Academy of Sciences of the United States of America.

[4]  A. Novick,et al.  Experiments with the Chemostat on spontaneous mutations of bacteria. , 1950, Proceedings of the National Academy of Sciences of the United States of America.

[5]  S. Zamenhof,et al.  Studies on mechanisms for the maintenance of constant mutability: mutability and the resistance to mutagens. , 1966, Proceedings of the National Academy of Sciences of the United States of America.

[6]  J. Ito,et al.  ON THE TRANSCRIPTION OF THE TRYTOPHAN OPERON IN ESCHERICHIA COLI. I. THE TRYPTOPHAN OPERATOR. , 1965, Journal of molecular biology.

[7]  J. Lederberg,et al.  Gene Linkage in DNA Transfer: A Cluster of Genes Concerned with Aromatic Biosynthesis in Bacillus Subtilis. , 1963, Genetics.

[8]  S. Zamenhof EFFECTS OF HEATING DRY BACTERIA AND SPORES ON THEIR PHENOTYPE AND GENOTYPE. , 1960, Proceedings of the National Academy of Sciences of the United States of America.

[9]  J. Bordet,et al.  L'évolution physiologique : étude des pertes de fonctions chez les microorganismes , 1944 .

[10]  S. Zamenhof Studies on Bacterial Mutability: The Time of Appearance of the Mutant in Escherichia coli , 1946, Journal of bacteriology.

[11]  C. Yanofsky,et al.  STUDIES ON THE REGULATION OF TRYPTOPHAN BIOSYNTHESIS IN ESCHERICHIA COLI. , 1965, Journal of molecular biology.