Occurrence of acute infectious bursal disease with high mortality in Japan and pathogenicity of field isolates in specific-pathogen-free chickens.

Highly virulent infectious bursal disease virus (IBDV) was isolated from field cases, and the pathogenicity of the isolates was examined in specific-pathogen-free chickens. Chickens inoculated with the isolates developed severe clinical disease with a high mortality rate. Histopathologically, infectious bursal disease was characterized by bursal and thymic necrosis, aplastic anemia, acute hepatitis with fatty change, and systemic inflammatory response. In addition to functional abnormalities in the liver, a hypoxic state was induced by aplastic anemia and severe inflammation in the pulmonary air capillary walls. These pathological changes appeared to be closely related to the cause of death.

[1]  M. Tajima,et al.  Detection of antibody to chicken anaemia agent: a comparison of three serological tests. , 1991, Avian pathology : journal of the W.V.P.A.

[2]  M. Mcnulty.  Chicken anaemia agent: a review. , 1991, Avian pathology : journal of the W.V.P.A.

[3]  G. Meulemans,et al.  Acute infectious bursal disease in poultry: Isolation and characterisation of a highly virulent strain. , 1991, Avian pathology : journal of the W.V.P.A.

[4]  V. Buêlow.  Avian infectious anemia and related syndromes caused by chicken anemia virus , 1991 .

[5]  A. Billiau,et al.  Chicken macrophage activation by interferon: do birds lack the molecular homologue of mammalian interferon-γ? , 1990 .

[6]  J. Okoye,et al.  Pathogenesis of infectious bursal disease in embryonally bursectomised chickens. , 1990, Avian pathology : journal of the W.V.P.A.

[7]  D. B. Snyder.  Changes in the field status of infectious bursal disease virus. , 1990, Avian pathology : journal of the W.V.P.A.

[8]  D. Lütticken,et al.  Antigenic characterization of IBDV field isolates by their reactivity with a panel of monoclonal antibodies. , 1990, DTW. Deutsche tierarztliche Wochenschrift.

[9]  J. Stuart,et al.  Outbreak of virulent infectious bursal disease in East Anglia , 1989, Veterinary Record.

[10]  J. Stuart.  Acute infectious bursal disease in poultry , 1989, Veterinary Record.

[11]  A. Metz,et al.  Comparative pathogenesis of serotype 1 and variant serotype 1 isolates of infectious bursal disease virus and their effect on humoral and cellular immune competence of specific-pathogen-free chickens. , 1989, Avian diseases.

[12]  T. Umemura,et al.  Histopathology of chicks inoculated with chicken anaemia agent (MSB1-TK5803 strain). , 1989, Avian pathology : journal of the W.V.P.A.

[13]  K. M. Lam.  Lysis of chicken lymphocytes by infectious bursal disease viruses. , 1988, Avian diseases.

[14]  T. Nunoya,et al.  Isolation of chicken anaemia agent and Marek's disease virus from chickens vaccinated with turkey herpesvirus and lesions induced in chicks by inoculating both agents. , 1987, Avian pathology : journal of the W.V.P.A.

[15]  A. Bickford,et al.  The pathogenesis of infectious bursal disease: serologic, histopathologic, and clinical chemical observations. , 1983, Avian diseases.

[16]  A. Fadly,et al.  Pathogenesis of infectious bursal disease in chickens infected with virus at various ages. , 1983, Avian diseases.

[17]  K. Hirai,et al.  In vitro infection of fractionated chicken lymphocytes by infectious bursal disease virus. , 1981, Avian diseases.

[18]  K. Schat,et al.  Pathogenesis of infectious bursal disease in embryonally bursectomized chickens. , 1981, Avian diseases.

[19]  M. Slavik,et al.  An age-related coagulation disorder associated with experimental infection with infectious bursal disease virus. , 1980, American journal of veterinary research.

[20]  B. Calnek,et al.  In vitro replication of infectious bursal disease virus in established lymphoid cell lines and chicken B lymphocytes , 1979, Infection and immunity.

[21]  O. Fletcher,et al.  Studies on interferon induction by infectious bursal disease virus (IBDV). II. Interferon production in White Leghorn chickens infected with an attenuated or pathogenic isolant of IBDV. , 1979, Avian diseases.

[22]  J. Gelb,et al.  Studies on Interferon Induction by Infectious Bursal Disease Virus (IBDV). I. Interferon Production in Chicken Embryo Cell Cultures Infected with IBDVA , 1979 .

[23]  T. Taniguchi,et al.  Isolation and some characteristics of an agent inducing anemia in chicks. , 1979 .

[24]  O. Fletcher,et al.  Infectious bursal disease viral infections. I. Complement and virus-neutralizing antibody response following infection of susceptible chickens. , 1979, Avian diseases.

[25]  A. Bickford,et al.  Immune-complex involvement in the pathogenesis of infectious bursal disease virus in chickens. , 1979, Avian diseases.

[26]  D. L. Brown.  COMPLEMENT AND COAGULATION , 1975, British journal of haematology.

[27]  義孝 鈴木,et al.  Infectious bursal disease virus (IBDV)の分離とわが国におけるIBDV沈降抗体の分布について , 1973 .

[28]  Cheville Nf.  Studies on the pathogenesis of Gumboro disease in the bursa of Fabricius, spleen, and thymus of the chicken. , 1967 .

[29]  J. Sever.  Application of a microtechnique to viral serological investigations. , 1962, Journal of immunology.