Cannabinoid-based drugs as anti-inflammatory therapeutics
暂无分享,去创建一个
[1] R. Hampson,et al. Cannabinoid physiology and pharmacology: 30 years of progress , 2004, Neuropharmacology.
[2] S. Burstein,et al. Pain reduction and lack of psychotropic effects with ajulemic acid: comment on the article by Sumariwalla et al. , 2004, Arthritis & Rheumatism.
[3] Georges J. M. Maestroni. The endogenous cannabinoid 2‐arachidonoyl glycerol as in vivo chemoattractant for dendritic cells and adjuvant for Th1 response to a soluble protein , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[4] K. Waku,et al. 2‐Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces the migration of EoL‐1 human eosinophilic leukemia cells and human peripheral blood eosinophils , 2004, Journal of leukocyte biology.
[5] C. Newton,et al. The THC‐induced suppression of Th1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2 , 2004, Journal of leukocyte biology.
[6] V. Marzo,et al. A new strategy to block tumor growth by inhibiting endocannabinoid inactivation , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[7] L. Petrocellis,et al. The endocannabinoid system and its therapeutic exploitation , 2004, Nature Reviews Drug Discovery.
[8] D. Wade,et al. Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients , 2004, Multiple sclerosis.
[9] C. Vaney,et al. Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study , 2004, Multiple sclerosis.
[10] Q. Pittman,et al. Effects of cannabinoid receptor‐2 activation on accelerated gastrointestinal transit in lipopolysaccharide‐treated rats , 2004, British journal of pharmacology.
[11] T. Jensen,et al. Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial , 2004, BMJ : British Medical Journal.
[12] B. Löwenberg,et al. The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner. , 2004, Blood.
[13] P. Pacher,et al. Cannabinoids cool the intestine , 2004, Nature Medicine.
[14] Shizuo Akira,et al. Toll-like receptor signalling , 2004, Nature Reviews Immunology.
[15] C. Piccirillo,et al. Cornerstone of peripheral tolerance: naturally occurring CD4+CD25+ regulatory T cells. , 2004, Trends in immunology.
[16] D. Ziedonis,et al. Advances in pharmacotherapy for tobacco dependence. , 2004, Expert opinion on emerging drugs.
[17] R. Pertwee,et al. Cannabinoids and glaucoma , 2004, British Journal of Ophthalmology.
[18] B. Cravatt,et al. The endogenous cannabinoid system protects against colonic inflammation. , 2004, The Journal of clinical investigation.
[19] R. Tuma,et al. Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model , 2004, Multiple sclerosis.
[20] K. Waku,et al. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells. , 2004, Journal of biochemistry.
[21] S. Black. Cannabinoid receptor antagonists and obesity. , 2004, Current opinion in investigational drugs.
[22] F. Rossi,et al. Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia‐reperfusion injury: involvement of cytokine/chemokines and PMN , 2004, Journal of leukocyte biology.
[23] M. Feldmann,et al. A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis. , 2004, Arthritis and rheumatism.
[24] P. Sonneveld,et al. Distinct Expression Profiles of the Peripheral Cannabinoid Receptor in Lymphoid Tissues Depending on Receptor Activation Status 1 , 2004, The Journal of Immunology.
[25] Marlene Wolf,et al. Chemokines: multiple levels of leukocyte migration control. , 2004, Trends in immunology.
[26] Thomas W. Klein,et al. Cannabinoid receptors and T helper cells , 2004, Journal of Neuroimmunology.
[27] Darrell R. Abernethy,et al. International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels , 2003, Pharmacological Reviews.
[28] J. Zajicek,et al. Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial , 2003, The Lancet.
[29] M. Yamakuchi,et al. Membrane cholesterol but not putative receptors mediates anandamide‐induced hepatocyte apoptosis , 2003, Hepatology.
[30] D. Piomelli. The molecular logic of endocannabinoid signalling , 2003, Nature Reviews Neuroscience.
[31] A. Thompson,et al. Cannabinoids inhibit neurodegeneration in models of multiple sclerosis. , 2003, Brain : a journal of neurology.
[32] C. Newton,et al. The cannabinoid system and immune modulation , 2003, Journal of leukocyte biology.
[33] M. Guzmán,et al. Cannabinoids: potential anticancer agents , 2003, Nature Reviews Cancer.
[34] E. Adler-Graschinsky,et al. Cannabinoid system as a potential target for drug development in the treatment of cardiovascular disease. , 2003, Current vascular pharmacology.
[35] D. Cockayne,et al. Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[36] N. Rothwell,et al. Endogenous Interleukin-1 Receptor Antagonist Mediates Anti-Inflammatory and Neuroprotective Actions of Cannabinoids in Neurons and Glia , 2003, The Journal of Neuroscience.
[37] J. Erb-Downward,et al. Production of Eicosanoids and Other Oxylipins by Pathogenic Eukaryotic Microbes , 2003, Clinical Microbiology Reviews.
[38] K. Nicolay,et al. Neuroprotection by the Endogenous Cannabinoid Anandamide and Arvanil against In Vivo Excitotoxicity in the Rat: Role of Vanilloid Receptors and Lipoxygenases , 2003, The Journal of Neuroscience.
[39] Hui Li,et al. Activation and binding of peroxisome proliferator-activated receptor gamma by synthetic cannabinoid ajulemic acid. , 2003, Molecular pharmacology.
[40] A. Thompson,et al. The therapeutic potential of cannabis , 2003, The Lancet Neurology.
[41] R. de la Torre,et al. Modulation of the immune system in cannabis users. , 2003, JAMA.
[42] D. Baker,et al. The therapeutic potential of cannabis in multiple sclerosis , 2003, Expert opinion on investigational drugs.
[43] J. Borrell,et al. Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis , 2003, The Journal of Neuroscience.
[44] S. Burstein,et al. Suppression of human monocyte interleukin-1beta production by ajulemic acid, a nonpsychoactive cannabinoid. , 2003, Biochemical pharmacology.
[45] K. Mackie,et al. Nonpsychotropic Cannabinoid Receptors Regulate Microglial Cell Migration , 2003, The Journal of Neuroscience.
[46] E. Del Giudice,et al. Cannabinoids ablate release of TNFα in rat microglial cells stimulated with lypopolysaccharide , 2003, Glia.
[47] D. Lehmann,et al. γ-Irradiation Enhances Apoptosis Induced by Cannabidiol, a Non-psychotropic Cannabinoid, in Cultured HL-60 Myeloblastic Leukemia Cells , 2003, Leukemia & lymphoma.
[48] M. Roth,et al. Δ9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells , 2002, Journal of Neuroimmunology.
[49] Sebastian Spindeldreher,et al. Clustering of MHC–peptide complexes prior to their engagement in the immunological synapse: lipid raft and tetraspan microdomains , 2002, Immunological reviews.
[50] I. Matias,et al. Presence and regulation of the endocannabinoid system in human dendritic cells. , 2002, European journal of biochemistry.
[51] Tony Wyss-Coray,et al. Inflammation in Neurodegenerative Disease—A Double-Edged Sword , 2002, Neuron.
[52] M. Adler,et al. Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[53] T. Bisogno,et al. Endocannabinoids as physiological regulators of colonic propulsion in mice. , 2002, Gastroenterology.
[54] M. Herkenham,et al. International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors , 2002, Pharmacological Reviews.
[55] J. Maffrand,et al. Functional assessment of neuronal cannabinoid receptors in the muscular layers of human ileum and colon. , 2002, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.
[56] N. Knoller,et al. Dexanabinol (HU-211) in the treatment of severe closed head injury: a randomized, placebo-controlled, phase II clinical trial. , 2002, Critical care medicine.
[57] M. Maccarrone,et al. Endocannabinoid degradation, endotoxic shock and inflammation. , 2002, Current drug targets. Inflammation and allergy.
[58] K. Waku,et al. Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. , 2002, Prostaglandins, leukotrienes, and essential fatty acids.
[59] M. Glass,et al. CB(1) and CB(2) receptor-mediated signalling: a focus on endocannabinoids. , 2002, Prostaglandins, leukotrienes, and essential fatty acids.
[60] R. Mechoulam,et al. Cannabinoids and brain injury: therapeutic implications. , 2002, Trends in molecular medicine.
[61] M. Kathmann,et al. Modulation of transmitter release via presynaptic cannabinoid receptors. , 2001, Trends in pharmacological sciences.
[62] S. Ben-Shabat,et al. An endogenous cannabinoid (2-AG) is neuroprotective after brain injury , 2001, Nature.
[63] R. Capasso,et al. Cannabinoid CB1‐receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation , 2001, British journal of pharmacology.
[64] L. Petrocellis,et al. Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes. , 2001, Archives of biochemistry and biophysics.
[65] G. Denhardt,et al. Modulation of cytokine responses in Corynebacterium parvum-primed endotoxemic mice by centrally administered cannabinoid ligands. , 2001, European journal of pharmacology.
[66] H. Weiner,et al. Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells , 2001, Immunological reviews.
[67] C. Newton,et al. Differential expression of cannabinoid CB(2) receptor mRNA in mouse immune cell subpopulations and following B cell stimulation. , 2001, European journal of pharmacology.
[68] C. Breivogel,et al. Evidence for a new G protein-coupled cannabinoid receptor in mouse brain. , 2001, Molecular pharmacology.
[69] M. Yamakuchi,et al. Simultaneous measurement of anandamide and 2-arachidonoylglycerol by polymyxin B-selective adsorption and subsequent high-performance liquid chromatography analysis: increase in endogenous cannabinoids in the sera of patients with endotoxic shock. , 2001, Analytical biochemistry.
[70] M. Christie,et al. Neurobiology: Cannabinoids act backwards , 2001, Nature.
[71] Z. Vogel,et al. 2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[72] B. Kelsall,et al. Regulation of interleukin-12 production by G-protein-coupled receptors. , 2001, Microbes and infection.
[73] T. Bisogno,et al. Endocannabinoids control spasticity in a multiple sclerosis model , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[74] E. Berdyshev,et al. Cannabinoid receptors and the regulation of immune response. , 2000, Chemistry and physics of lipids.
[75] C. Newton,et al. Anti-CD40, anti-CD3, and IL-2 stimulation induce contrasting changes in CB1 mRNA expression in mouse splenocytes , 2000, Journal of Neuroimmunology.
[76] M. Feldmann,et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[77] Li Zhu,et al. Δ-9-Tetrahydrocannabinol Inhibits Antitumor Immunity by a CB2 Receptor-Mediated, Cytokine-Dependent Pathway1 , 2000, The Journal of Immunology.
[78] C. Newton,et al. Δ9-Tetrahydrocannabinol Treatment Suppresses Immunity and Early IFN-γ, IL-12, and IL-12 Receptor β2 Responses to Legionella pneumophila Infection1 , 2000, The Journal of Immunology.
[79] G. Denhardt,et al. Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice. , 2000, The Journal of pharmacology and experimental therapeutics.
[80] R. Pertwee,et al. Cannabinoids control spasticity and tremor in a multiple sclerosis model , 2000, Nature.
[81] M. Cortés,et al. Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation , 2000, Nature Medicine.
[82] N. Kaminski,et al. Cannabinol-mediated inhibition of nuclear factor-kappaB, cAMP response element-binding protein, and interleukin-2 secretion by activated thymocytes. , 1999, The Journal of pharmacology and experimental therapeutics.
[83] M. S. Taylor,et al. 1',1'-Dimethylheptyl-delta-8-tetrahydrocannabinol-11-oic acid: a novel, orally effective cannabinoid with analgesic and anti-inflammatory properties. , 1999, The Journal of pharmacology and experimental therapeutics.
[84] T. Kawai,et al. Selective diapedesis of Th1 cells induced by endothelial cell RANTES. , 1999, Journal of immunology.
[85] L. Petrocellis,et al. Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages. , 1999, European journal of biochemistry.
[86] D. Julius,et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide , 1999, Nature.
[87] S. Burstein,et al. The cannabinoid acids: nonpsychoactive derivatives with therapeutic potential. , 1999, Pharmacology & therapeutics.
[88] A. Doble. The role of excitotoxicity in neurodegenerative disease: implications for therapy. , 1999 .
[89] G. Kunos,et al. Platelet‐ and macrophage‐derived endogenous cannabinoids are involved in endotoxin‐induced hypotension , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[90] C. Newton,et al. Cannabinoid receptors and immunity. , 1998, Immunology today.
[91] D. Piomelli,et al. Control of pain initiation by endogenous cannabinoids , 1998, Nature.
[92] L. Petrocellis,et al. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[93] G. Cabral,et al. Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease , 1998, Journal of Neuroimmunology.
[94] A. Biegon,et al. Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production by dexanabinol (HU-211), a nonpsychotropic cannabinoid. , 1997, The Journal of pharmacology and experimental therapeutics.
[95] A. N. Park,et al. Marijuana and cocaine impair alveolar macrophage function and cytokine production. , 1997, American journal of respiratory and critical care medicine.
[96] W. Kingery,et al. A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes , 1997, Pain.
[97] Z. Vogel,et al. Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase. , 1997, Journal of medicinal chemistry.
[98] T. Ben-Hur,et al. Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-α inhibitor and an effective neuroprotectant , 1997, Journal of Neuroimmunology.
[99] V. Di Marzo,et al. Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells. , 1996, The Biochemical journal.
[100] Y. Daaka,et al. Cannabinoid receptor proteins are increased in Jurkat, human T-cell line after mitogen activation. , 1996, The Journal of pharmacology and experimental therapeutics.
[101] Y. Daaka,et al. Δ9-Tetrahydrocannabinol, Cytokines, and Immunity to Legionella pneumophila , 1995, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.
[102] Z. Vogel,et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. , 1995, Biochemical pharmacology.
[103] R. Mechoulam,et al. Suppression of experimental autoimmune encephalomyelitis by cannabinoids. , 1994, Immunopharmacology.
[104] Y. Daaka,et al. delta 9-Tetrahydrocannabinol enhances the secretion of interleukin 1 from endotoxin-stimulated macrophages. , 1994, The Journal of pharmacology and experimental therapeutics.
[105] C. Newton,et al. Secondary immunity to Legionella pneumophila and Th1 activity are suppressed by delta-9-tetrahydrocannabinol injection , 1994, Infection and immunity.
[106] G. Cabral,et al. Delta 9-tetrahydrocannabinol inhibition of tumor necrosis factor-alpha: suppression of post-translational events. , 1993, The Journal of pharmacology and experimental therapeutics.
[107] C. Newton,et al. Delta 9-tetrahydrocannabinol injection induces cytokine-mediated mortality of mice infected with Legionella pneumophila. , 1993, The Journal of pharmacology and experimental therapeutics.
[108] S. Munro,et al. Molecular characterization of a peripheral receptor for cannabinoids , 1993, Nature.
[109] D. Gibson,et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. , 1992, Science.
[110] T. Bonner,et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA , 1990, Nature.
[111] C. Brosnan,et al. Δ 9-Tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis , 1989, Journal of Neuroimmunology.
[112] G. Cabral,et al. Δ9-Tetrahydrocannabinol Decreases Alpha/Beta Interferon Response to Herpes Simplex Virus Type 2 in the B6C3F1 Mouse 1 , 1986, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.
[113] R. Mechoulam,et al. Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish , 1964 .
[114] C. Newton,et al. Newton, C. A. et al. The THC-induced suppression of TH1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2. J. Leukoc. Biol. 76, 854-861 , 2004 .
[115] S. Miller,et al. Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R+WIN55,212. , 2003, The Journal of clinical investigation.
[116] G. Cabral,et al. Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation. , 2002, International immunopharmacology.
[117] Wan-Wan Lin,et al. Effects of cannabinoids on LPS‐stimulated inflammatory mediator release from macrophages: Involvement of eicosanoids , 2001, Journal of cellular biochemistry.
[118] Prabir Ray,et al. A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation , 2001, Nature Immunology.
[119] F. Wong,et al. IFN- Affects Homing of Diabetogenic T Cells , 2001 .
[120] C. Newton,et al. The cannabinoid system and cytokine network. , 2000, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.
[121] Li Zhu,et al. D-9-Tetrahydrocannabinol Inhibits Antitumor Immunity by a CB2 Receptor-Mediated, Cytokine-Dependent Pathway , 2000 .
[122] S. Burstein,et al. Dimethylheptyl-THC-11-oic Acid , 1999 .
[123] S. Burstein,et al. Dimethylheptyl-THC-11 oic acid: a nonpsychoactive antiinflammatory agent with a cannabinoid template structure. , 1998, Arthritis and rheumatism.
[124] C. Newton,et al. In vitro and in vivo suppressive effects of delta-9-tetrahydrocannabinol on interferon production by murine spleen cells. , 1986, International journal of immunopharmacology.