Role of Argyrophilic Nucleolar Organiser Region Staining in Effusions for Detection of Malignancy - Diagnostic Test Evaluation

1 Senior Resident, 2 Assistant Professor, 3 Professor Dept of Pathology, Government Medical College, Thrissur, Kerala Corresponding Author Dr Freena Rose Assistant Professor, Dept of Pathology, Government Medical College, Thrissur, Kerala, Pin 680596 Phone No: 9446551832, 0487 2204832, Email: freenarose@yahoo.com ABSTRACT The frequency of AgNORs within the nuclei is higher in malignant cells than in normal, reactive or benign neoplastic cells. 80 serous effusions received in the Cytology Lab during the study period, which could be proved as benign or malignant by biopsy were included & AgNOR study was done. Statistically significant difference was noted in AgNOR size, count, dispersion & mean AgNOR value between benign & malignant effusions. AgNOR study appears to be clinically useful as an additional diagnostic tool in serous effusion when the cytologic diagnosis is difficult.

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