Reprogramming ovarian and breast cancer cells into non-cancerous cells by low-dose metformin or SN-38 through FOXO3 activation
暂无分享,去创建一个
J. Berek | M. Hu | Y. Chung | Jessica Ma | Theodore Hu | Michael Ma | M. Guan
[1] Amy M. Sitapati,et al. NCCN Guidelines Insights: Breast Cancer, Version 1.2017. , 2017, Journal of the National Comprehensive Cancer Network : JNCCN.
[2] P. Lollini,et al. Metformin as an Adjuvant Drug against Pediatric Sarcomas: Hypoxia Limits Therapeutic Effects of the Drug , 2013, PloS one.
[3] Ying Jiang,et al. Foxo3a Expression Is a Prognostic Marker in Breast Cancer , 2013, PloS one.
[4] G. Stephanopoulos,et al. Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. , 2013, Cancer research.
[5] J. Ferlay,et al. Global estimates of cancer prevalence for 27 sites in the adult population in 2008 , 2013, International journal of cancer.
[6] M. Choti,et al. Metastatic colon cancer, version 3.2013: featured updates to the NCCN Guidelines. , 2013, Journal of the National Comprehensive Cancer Network : JNCCN.
[7] Edward Kai-Hua Chow,et al. Mechanisms of chemoresistance in cancer stem cells , 2013, Clinical and Translational Medicine.
[8] R. Labianca,et al. ESMO Consensus Guidelines for management of patients with colon and rectal cancer. a personalized approach to clinical decision making. , 2012, Annals of oncology : official journal of the European Society for Medical Oncology.
[9] David J. Chen,et al. FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage , 2012, Nature Communications.
[10] Richard J. Jones,et al. Concise Review: Cancer Stem Cells and Minimal Residual Disease , 2012, Stem cells.
[11] N. Nguyen,et al. Differentiation of breast cancer stem cells by knockdown of CD44: promising differentiation therapy , 2011, Journal of Translational Medicine.
[12] S. Gygi,et al. Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. , 2011, Molecular cell.
[13] J. Schroeder,et al. Understanding the Dual Nature of CD44 in Breast Cancer Progression , 2011, Molecular Cancer Research.
[14] Shailendra Giri,et al. Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo. , 2011, Neoplasia.
[15] I. Ellis,et al. FOXO3a nuclear localisation is associated with good prognosis in luminal-like breast cancer , 2011, Breast Cancer Research and Treatment.
[16] J. Campisi,et al. DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion , 2011, Journal of Cell Science.
[17] K. Nakayama,et al. Inhibition of FOXO3 Tumor Suppressor Function by βTrCP1 through Ubiquitin-Mediated Degradation in a Tumor Mouse Model , 2010, PloS one.
[18] I. Ben-Sahra,et al. Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug? , 2010, Molecular Cancer Therapeutics.
[19] David A Hess,et al. High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability , 2009, Journal of cellular and molecular medicine.
[20] Peter G Schultz,et al. Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4 , 2009, Proceedings of the National Academy of Sciences.
[21] Chun Cheng,et al. Low expression of Foxo3a is Associated with Poor Prognosis in Ovarian Cancer Patients , 2009, Cancer investigation.
[22] T. Roberts,et al. Simian Virus 40 Large T Antigen Disrupts Genome Integrity and Activates a DNA Damage Response via Bub1 Binding , 2008, Journal of Virology.
[23] Katsuhiko Yano,et al. FOXO3A genotype is strongly associated with human longevity , 2008, Proceedings of the National Academy of Sciences.
[24] Xiao-Feng Sun,et al. Anticancer effect of SN-38 on colon cancer cell lines with different metastatic potential. , 2008, Oncology reports.
[25] Curt Balch,et al. Identification and characterization of ovarian cancer-initiating cells from primary human tumors. , 2008, Cancer research.
[26] Zhaohui Xu,et al. Functional interaction between FOXO3a and ATM regulates DNA damage response , 2008, Nature Cell Biology.
[27] S. Gygi,et al. The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor* , 2007, Journal of Biological Chemistry.
[28] H. Nakauchi,et al. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. , 2007, Cell stem cell.
[29] Yonghong Xiao,et al. FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis , 2007, Cell.
[30] Nahum Sonenberg,et al. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. , 2006, Cancer research.
[31] W. Xia,et al. Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis. , 2006, International journal of oncology.
[32] W. Zong,et al. Chemotherapeutic approaches for targeting cell death pathways. , 2006, The oncologist.
[33] S. Majumdar,et al. Increased Cancer-Related Mortality for Patients With Type 2 Diabetes Who Use Sulfonylureas or Insulin , 2006, Diabetes Care.
[34] E. Greer,et al. FOXO transcription factors at the interface between longevity and tumor suppression , 2005, Oncogene.
[35] M. Goodarzi,et al. Metformin revisited: re‐evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents , 2005, Diabetes, obesity & metabolism.
[36] C. Franceschi,et al. Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice , 2005, Experimental Gerontology.
[37] N. Motoyama,et al. FOXO transcription factors in cell-cycle regulation and the response to oxidative stress. , 2005, Antioxidants & redox signaling.
[38] Dario R Alessi,et al. Metformin and reduced risk of cancer in diabetic patients , 2005, BMJ : British Medical Journal.
[39] S. Nemoto,et al. Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway , 2004, Science.
[40] D. Pipeleers,et al. Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis. , 2004, Biochemical pharmacology.
[41] Christopher J Bakkenist,et al. Initiating Cellular Stress Responses , 2004, Cell.
[42] S. Anderson,et al. Integration of Smad and Forkhead Pathways in the Control of Neuroepithelial and Glioblastoma Cell Proliferation , 2004, Cell.
[43] Ryuji Kobayashi,et al. IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a , 2004, Cell.
[44] V. Triggiani,et al. Evidence for a putative relationship between type 2 diabetes and neoplasia with particular reference to breast cancer: role of hormones, growth factors and specific receptors. , 2004, Current drug targets. Immune, endocrine and metabolic disorders.
[45] R. Coombes,et al. FoxO3a Transcriptional Regulation of Bim Controls Apoptosis in Paclitaxel-treated Breast Cancer Cell Lines* , 2003, Journal of Biological Chemistry.
[46] Robert S Mannel,et al. Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[47] S. R. Datta,et al. DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein , 2002, Science.
[48] C. Martínez-A,et al. Forkhead transcription factors contribute to execution of the mitotic programme in mammals , 2001, Nature.
[49] Margaret S. Wu,et al. Role of AMP-activated protein kinase in mechanism of metformin action. , 2001, The Journal of clinical investigation.
[50] X. Ding,et al. Prevention of pancreatic cancer induction in hamsters by metformin. , 2001, Gastroenterology.
[51] M. Greenberg,et al. Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor , 1999, Cell.
[52] P. Houghton,et al. Studies of the efficacy and pharmacology of irinotecan against human colon tumor xenograft models. , 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.
[53] E. Partridge,et al. Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer , 1996, The New England journal of medicine.
[54] H. Kuga,et al. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. , 1991, Cancer research.
[55] R. Hertzberg,et al. Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity. , 1989, Journal of medicinal chemistry.
[56] R. Bast,et al. Reactivity of a monoclonal antibody with human ovarian carcinoma. , 1981, The Journal of clinical investigation.
[57] C. M. Oslowski. Stress Responses , 2015, Methods in Molecular Biology.
[58] A. Jemal,et al. Cancer statistics, 2012 , 2012, CA: a cancer journal for clinicians.
[59] D. Troyer,et al. Topoisomerase I inhibitor SN-38 effectively attenuates growth of human non-small cell lung cancer cell lines in vitro and in vivo. , 2011, Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.
[60] N. Dubrawsky. Cancer statistics , 1989, CA: a cancer journal for clinicians.