A review and meta-analysis of hormonal treatment of cryptorchidism.

To assess the effect of LH-releasing hormone (LHRH) and hCG in the treatment of cryptorchidism, 33 articles published in English between 1958-1990 were analyzed. Altogether, 3282 boys with 4524 undescended testes were included in the analysis; 872 boys with 1174 undescended testes were treated in randomized trials. The meta-analysis showed LHRH to be more effective than placebo; the risk ratio was 3.21 [95% confidence interval (CI) of 1.83-5.64] and 2.57 (95% CI, 1.39-4.74) in trials excluding retractile testes, respectively. In the combined randomized trials, the success rate with LHRH was 21% (95% CI, 18-24%), that with hCG was 19% (95% CI, 13-25%), and that with placebo was 4% (95% CI, 2-6%). The effect of the hormonal treatment was overestimated in nonrandomized trials. In conclusion, LHRH is effective in the treatment of cryptorchidism, and hCG is more effective than placebo, but data about the effect are scanty.

[1]  G. Bartsch,et al.  Therapeutic Effects of Luteinizing Hormone Releasing Hormone (LH‐RH) in Cryptorchidism , 2009, Andrologia.

[2]  B. Jacobsen,et al.  Hormonal treatment of cryptorchidism—hCG or GnRH—a multicentre study , 1992, Acta paediatrica.

[3]  S. Adamsen,et al.  Prospective evaluation of human chorionic gonadotropin in the treatment of cryptorchidism. , 1989, Acta chirurgica Scandinavica.

[4]  J. Moul,et al.  A review of surgical treatment of undescended testes with emphasis on anatomical position. , 1988, The Journal of urology.

[5]  T. Chalmers,et al.  Meta-analyses of randomized controlled trials. , 1987, The New England journal of medicine.

[6]  J. Wit,et al.  EFFECT OF LHRH TREATMENT ON TESTICULAR DESCENT AND HORMONAL RESPONSE IN CRYPTORCHIDISM , 1986, Clinical endocrinology.

[7]  A. Matroos,et al.  DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF LUTEINISING-HORMONE- RELEASING-HORMONE NASAL SPRAY IN TREATMENT OF UNDESCENDED TESTES , 1986, The Lancet.

[8]  David Handelsman,et al.  Hormonal therapy of cryptorchidism. A randomized, double-blind study comparing human chorionic gonadotropin and gonadotropin-releasing hormone. , 1986, The New England journal of medicine.

[9]  P. Swift,et al.  Luteinising hormone releasing hormone for incomplete descent of the testis. , 1985, Archives of disease in childhood.

[10]  M. Perišić,et al.  Success and Relapse Rate after Treatment of Cryptorchidism with Intranasal LHRH , 1985, Acta paediatrica Scandinavica.

[11]  J. Thorup,et al.  Clinical results of early and late operative correction of undescended testes. , 1984, British journal of urology.

[12]  P. Eneroth,et al.  LHRH treatment in unilateral cryptorchidism: effect on testicular descent and hormonal response. , 1983, The Journal of pediatrics.

[13]  S. Mallal,et al.  Treatment of cryptorchidism with pulsatile luteinizing hormone-releasing hormone (LH-RH). , 1983, Journal of pediatric surgery.

[14]  J. Garagorri,et al.  Hormonal therapy of cryptorchidism with human chorionic gonadotropin(HCG). , 1982, The Urologic clinics of North America.

[15]  F. Hadžiselimović.  Hormonal treatment of cryptorchidism. , 1982, The New England journal of medicine.

[16]  J. Beyer,et al.  Treatment of cryptorchidism with pernasal gonadotropin-releasing hormone therapy. , 1978, Fertility and sterility.

[17]  A. Eshkol,et al.  Treatment of cryptorchidism with a potent analog of gonadotropin-releasing hormone. , 1978, Fertility and sterility.

[18]  M. Villa,et al.  Luteinising hormone-releasing hormone nasal spray as therapy for undescended testicle. , 1978, Archives of disease in childhood.

[19]  A. Prader,et al.  TREATMENT OF CRYPTORCHIDISM BY INTRANASAL SYNTHETIC LUTEINISING-HORMONE RELEASING HORMONE Results of a Collaborative Double-blind Study , 1977, The Lancet.

[20]  J. Beyer,et al.  Intranasal GnRH therapy of maldescended testes. , 1975, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[21]  H. Seguchi,et al.  Surgical correction of cryptorchism at 2 years: electron microscopic and morphometric investigations. , 1975, Journal of pediatric surgery.

[22]  L. Osment.  International Health Foundation , 1973 .

[23]  C. G. Bergstrand,et al.  TREATMENT OF UNDESCENDED TESTIS WITH HUMAN CHORIONIC GONADOTROPHIN , 1961 .

[24]  C. G. Bergstrand,et al.  Treatment of the Undescended Testis , 1960 .

[25]  P. Bishop,et al.  Management of the Undescended Testis , 1958, British medical journal.

[26]  R. Gross,et al.  Surgical experiences from 1,222 operations for undescended testis. , 1956, Journal of the American Medical Association.

[27]  B. Schapiro.  Kann man mit Hypophysenvorderlappen den unterentwickelten männlichen Genitalapparat beim Menschen zum Wachstum anregen? , 1930 .

[28]  J. Witjes,et al.  Use of luteinizing-hormone-releasing hormone nasal spray in the treatment of cryptorchidism: is there still an indication? A clinical study in 78 boys with 103 undescended testicles. , 1990, European urology.

[29]  B. Jacobsen,et al.  Treatment of cryptorchidism with human chorionic gonadotropin or gonadotropin releasing hormone. A double-blind controlled study of 243 boys. , 1988, Hormone research.

[30]  S. M. Keizer-Schrama.  Hormonal treatment of cryptorchidism. , 1988 .

[31]  M. Forest,et al.  Undescended testis: comparison of two protocols of treatment with human chorionic gonadotropin. Effect on testicular descent and hormonal response. , 1988, Hormone research.

[32]  V. Hesse,et al.  Three injections of human chorionic gonadotropin are as effective as ten injections in the treatment of cryptorchidism. , 1988, Hormone research.

[33]  S. Corsello,et al.  Treatment of undescended testes with hMG and hMG plus hCG: clinical, hormonal and sonographic evaluation. , 1987, Annales d'endocrinologie.