Clozapine and aripiprazole‐induced neutropenia

Neutropenia is a well‐known adverse side‐effect of clozapine that can also be seen with other atypical antipsychotics. In this article the authors discuss a patient who experienced neutropenia with clozapine and who subsequently redeveloped neutropenia with aripiprazole after a short trial. The case illustrates that close monitoring and caution is advisable when trialing patients on any further antipsychotics after a neutropenic event with clozapine.

[1]  C. Meza,et al.  Suspected Aripiprazole-induced neutropenia in a geriatric patient: a case report , 2020, BMC Geriatrics.

[2]  M. Large,et al.  A meta-analysis of controlled studies comparing the association between clozapine and other antipsychotic medications and the development of neutropenia , 2019, The Australian and New Zealand journal of psychiatry.

[3]  Amar K. Das,et al.  Differences in Antipsychotic-Related Adverse Events in Adult, Pediatric, and Geriatric Populations , 2017, Cureus.

[4]  Maudsley Nhs Trust,et al.  The Maudsley Prescribing Guidelines in Psychiatry , 2015 .

[5]  T. Park,et al.  A Case with Neutropenia Related with the Use of Various Atypical Antipsychotics , 2013, Psychiatry investigation.

[6]  A. E. Altınöz,et al.  Does Switching to Another Antipsychotic in Patients With Clozapine-Associated Granulocytopenia Solve the Problem?: Case Series of 18 Patients , 2011, Journal of clinical psychopharmacology.

[7]  S. Qureshi,et al.  Risperidone- and aripiprazole-induced leukopenia: a case report. , 2008, Primary care companion to the Journal of clinical psychiatry.

[8]  A. John,et al.  Severe serotonin toxicity and manic switch induced by combined use of tramadol and paroxetine. , 2007, The Australian and New Zealand journal of psychiatry.

[9]  K. Jacob,et al.  Reversible neutropenia with olanzapine following clozapine-induced neutropenia. , 2006, The American journal of psychiatry.

[10]  A. Sayın,et al.  Prolongation of clozapine-induced leukopenia with olanzapine treatment , 2006, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[11]  N. Patel,et al.  Sudden Late Onset of Clozapine-Induced Agranulocytosis , 2002, The Annals of pharmacotherapy.

[12]  M. Pato,et al.  Olanzapine prolongation of granulocytopenia after clozapine discontinuation. , 2000, Journal of clinical psychopharmacology.

[13]  E. Smeraldi,et al.  Olanzapine-induced neutropenia after clozapine-induced neutropenia , 1999, The Lancet.

[14]  W. Honer,et al.  Prolongation of clozapine-induced granulocytopenia associated with olanzapine. , 1997, Journal of clinical psychopharmacology.

[15]  Z. Dernovsek,et al.  Risperidone-induced leucopenia and neutropenia , 1997, British Journal of Psychiatry.

[16]  H. Freeman,et al.  Neutropenia and Agranulocytosis in Patients Receiving Clozapine in the UK and Ireland , 1996, British Journal of Psychiatry.

[17]  T. Lambert Olanzapine after clozapine: the rare case of prolongation of granulocytopaenia. , 1998, The Australian and New Zealand journal of psychiatry.