Ectopic BAT mUCP-1 overexpression in SKM by delivering a BMP7/PRDM16/PGC-1a gene cocktail or single PRMD16 using non-viral UTMD gene therapy

[1]  F. Pi‐Sunyer,et al.  Biological mechanisms that promote weight regain following weight loss in obese humans , 2013, Physiology & Behavior.

[2]  A. Joyner,et al.  Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. , 2006, Developmental biology.

[3]  S. Cinti,et al.  Distribution and development of brown adipocytes in the murine and human adipose organ. , 2010, Cell metabolism.

[4]  S. Enerbäck,et al.  Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease , 2018, Nature Reviews Endocrinology.

[5]  Zhi-Yi Chen,et al.  New development and application of ultrasound targeted microbubble destruction in gene therapy and drug delivery. , 2013, Current gene therapy.

[6]  A. Garnier,et al.  Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. , 2008, Cardiovascular research.

[7]  A. Voigt,et al.  Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity , 2015, Genes & Nutrition.

[8]  Mark A. Kay,et al.  Progress and problems with the use of viral vectors for gene therapy , 2003, Nature Reviews Genetics.

[9]  B. Spiegelman,et al.  FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. , 2012, Genes & development.

[10]  D. Nicholls.  The physiological regulation of uncoupling proteins. , 2006, Biochimica et biophysica acta.

[11]  A. Voigt,et al.  Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice , 2011, Aging cell.

[12]  J. Keijer,et al.  Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine. , 2014, American journal of physiology. Endocrinology and metabolism.

[13]  A. Astrup,et al.  Clinical significance of adaptive thermogenesis , 2007, International Journal of Obesity.

[14]  S. Farmer.  Brown Fat and Skeletal Muscle: Unlikely Cousins? , 2008, Cell.

[15]  P. Seale.  Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation , 2015, Diabetes.

[16]  R. DeFronzo,et al.  Successful pharmaceutical‐grade streptozotocin (STZ)‐induced hyperglycemia in a conscious tethered baboon (Papio hamadryas) model , 2015, Journal of medical primatology.

[17]  C. Kahn,et al.  New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure , 2008, Nature.

[18]  H. Wyatt,et al.  Using the energy gap to address obesity: a commentary. , 2009, Journal of the American Dietetic Association.

[19]  A. Halpern,et al.  Brown adipose tissue: what have we learned since its recent identification in human adults. , 2014, Arquivos brasileiros de endocrinologia e metabologia.

[20]  E. Ravussin,et al.  Brown Adipose Tissue: an Update on Recent Findings , 2017, Current Obesity Reports.

[21]  G. Frühbeck,et al.  Crosstalk between adipokines and myokines in fat browning , 2017, Acta physiologica.

[22]  D. Goldhamer,et al.  MyoD-expressing progenitors are essential for skeletal myogenesis and satellite cell development. , 2013, Developmental biology.

[23]  Douglas A. Melton,et al.  In vivo reprogramming of adult pancreatic exocrine cells to β-cells , 2008, Nature.

[24]  H. Katus,et al.  Microbubbles as a vehicle for gene and drug delivery: current clinical implications and future perspectives. , 2012, Current pharmaceutical design.

[25]  Troy H. Farncombe,et al.  A standardized infrared imaging technique that specifically detects UCP1-mediated thermogenesis in vivo , 2014, Molecular metabolism.

[26]  S. Rössner,et al.  Obesity management: what brings success? , 2013, Therapeutic advances in gastroenterology.

[27]  Nadejda V. Mezentseva,et al.  The brown adipocyte differentiation pathway in birds: An evolutionary road not taken , 2008, BMC Biology.

[28]  Steven P. Gygi,et al.  Initiation of myoblast/brown fat switch through a PRDM16-C/EBP-β transcriptional complex , 2009, Nature.

[29]  H. G. Wang,et al.  Transposon mutagenesis of baculoviruses: analysis of Trichoplusia ni transposon IFP2 insertions within the FP-locus of nuclear polyhedrosis viruses. , 1989, Virology.

[30]  C. Melby,et al.  Attenuating the Biologic Drive for Weight Regain Following Weight Loss: Must What Goes Down Always Go Back Up? , 2017, Nutrients.

[31]  Raffi Bekeredjian,et al.  Optimization of ultrasound parameters for cardiac gene delivery of adenoviral or plasmid deoxyribonucleic acid by ultrasound-targeted microbubble destruction. , 2003, Journal of the American College of Cardiology.

[32]  A. Zamyatnin,et al.  Viral vectors for gene therapy: Current state and clinical perspectives , 2016, Biochemistry (Moscow).

[33]  R. Hammer,et al.  White Fat Progenitor Cells Reside in the Adipose Vasculature , 2008, Science.

[34]  P. Watson,et al.  Real-time PCR complements immunohistochemistry in the determination of HER-2/neu status in breast cancer , 2006, BMC clinical pathology.

[35]  Robert J. Lee,et al.  Ultrasound-Targeted Microbubble Destruction (UTMD) Assisted Delivery of shRNA against PHD2 into H9C2 Cells , 2015, PloS one.

[36]  F. B. Sørensen,et al.  Real-time quantitative PCR of microdissected paraffin-embedded breast carcinoma: an alternative method for HER-2/neu analysis. , 2004, The Journal of molecular diagnostics : JMD.

[37]  K. Ho,et al.  Infrared thermography in the detection of brown adipose tissue in humans , 2014, Physiological reports.

[38]  S. Aslibekyan,et al.  Obesity: Obesity and cardiometabolic disease — more than meets the eye , 2017, Nature Reviews Endocrinology.

[39]  N. Byrne,et al.  Energy Gap in the Aetiology of Body Weight Gain and Obesity: A Challenging Concept with a Complex Evaluation and Pitfalls , 2014, Obesity Facts.

[40]  M. Christian,et al.  The engineering of brown fat. , 2010, Journal of molecular cell biology.

[41]  Alan D. Lopez,et al.  Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013 , 2014, The Lancet.

[42]  A. Kimmel,et al.  Perilipin 5, a lipid droplet protein adapted to mitochondrial energy utilization , 2014, Current opinion in lipidology.

[43]  M. Reilly,et al.  Targeting adipose tissue via systemic gene therapy , 2014, Gene Therapy.

[44]  A. Bradley,et al.  A hyperactive piggyBac transposase for mammalian applications , 2011, Proceedings of the National Academy of Sciences.

[45]  S. Cinti.  Between brown and white: Novel aspects of adipocyte differentiation , 2011, Annals of medicine.

[46]  A. Dulloo,et al.  Annals of the New York Academy of Sciences Translational Issues in Targeting Brown Adipose Tissue Thermogenesis for Human Obesity Management , 2022 .

[47]  L. L. de Matos,et al.  Immunohistochemistry as an Important Tool in Biomarkers Detection and Clinical Practice , 2010, Biomarker insights.

[48]  Shi-You Chen,et al.  White adipose tissue browning and obesity , 2016, Journal of biomedical research.

[49]  N. Chao.  Faculty Opinions recommendation of In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. , 2008 .

[50]  A. Xu,et al.  Delivery of adiponectin gene to skeletal muscle using ultrasound targeted microbubbles improves insulin sensitivity and whole body glucose homeostasis. , 2013, American journal of physiology. Endocrinology and metabolism.

[51]  P. Grayburn,et al.  Transient overexpression of cyclin D2/CDK4/GLP1 genes induces proliferation and differentiation of adult pancreatic progenitors and mediates islet regeneration , 2012, Cell cycle.

[52]  Jan Nedergaard,et al.  Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages , 2007, Proceedings of the National Academy of Sciences.

[53]  A Arkudas,et al.  A new approach to tissue engineering of vascularized skeletal muscle , 2006, Journal of cellular and molecular medicine.

[54]  R. DeFronzo,et al.  Successful β cells islet regeneration in streptozotocin-induced diabetic baboons using ultrasound-targeted microbubble gene therapy with cyclinD2/CDK4/GLP1 , 2014, Cell cycle.

[55]  Y. Duan,et al.  Myokines and adipokines: Involvement in the crosstalk between skeletal muscle and adipose tissue. , 2017, Cytokine & growth factor reviews.

[56]  K. Bae,et al.  Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells. , 2014, World journal of stem cells.

[57]  A. Greenberg,et al.  Perilipin Overexpression in White Adipose Tissue Induces a Brown Fat-Like Phenotype , 2010, PloS one.

[58]  S. Klaus,et al.  Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1. , 2008, Physiological genomics.

[59]  Explaining the failures of obesity therapy: willpower attenuation, target miscalculation or metabolic compensation? , 2012, International Journal of Obesity.

[60]  B. Spiegelman.  Banting Lecture 2012 , 2013, Diabetes.

[61]  C. S. Shaw,et al.  Immunofluorescence microscopy of SNAP23 in human skeletal muscle reveals colocalization with plasma membrane, lipid droplets, and mitochondria , 2016, Physiological reports.

[62]  J. Kent,et al.  Engineering brown fat into skeletal muscle using ultrasound‐targeted microbubble destruction gene delivery in obese Zucker rats: Proof of concept design , 2017, IUBMB life.

[63]  B. Spiegelman,et al.  Transcriptional control of brown fat determination by PRDM16. , 2007, Cell metabolism.