International Journal of Nanomedicine Dovepress Nano-zinc Oxide Damages Spatial Cognition Capability via Over-enhanced Long-term Potentiation in Hippocampus of Wistar Rats

This study focused on the effects of zinc oxide nanoparticles (nano-ZnO) on spatial learning and memory and synaptic plasticity in the hippocampus of young rats, and tried to interpret the underlying mechanism. Rats were randomly divided into four groups. Nano-ZnO and phosphate-buffered saline were administered in 4-week-old rats for 8 weeks. Subsequently, performance in Morris water maze (MWM) was determined, and then long-term potentiation (LTP) and depotentiation were measured in the perforant pathway to dentate gyrus (DG) in anesthetized rats. The data showed that, (1) in MWM, the escape latency was prolonged in the nano-ZnO group and, (2) LTP was significantly enhanced in the nano-ZnO group, while depo-tentiation was barely influenced in the DG region of the nano-ZnO group. This bidirectional effect on long-term synaptic plasticity broke the balance between stability and flexibility of cognition. The spatial learning and memory ability was attenuated by the alteration of synaptic plasticity in nano-ZnO-treated rats.

[1]  A. Kirkwood,et al.  Zinc enhances long‐term potentiation through P2X receptor modulation in the hippocampal CA1 region , 2011, The European journal of neuroscience.

[2]  S. Krol,et al.  Functionalized gold nanoparticles: a detailed in vivo multimodal microscopic brain distribution study. , 2010, Nanoscale.

[3]  N. Oku,et al.  Zinc-mediated attenuation of hippocampal mossy fiber long-term potentiation induced by forskolin , 2010, Neurochemistry International.

[4]  Miki Suzuki,et al.  Differential effects of zinc influx via AMPA/kainate receptor activation on subsequent induction of hippocampal CA1 LTP components , 2010, Brain Research.

[5]  S. K. Sadrnezhaad,et al.  The seeding effect on the microstructure and photocatalytic properties of ZnO nano powders , 2010 .

[6]  M. Ma̧czka,et al.  Phonon properties of nanosized bismuth layered ferroelectric material—Bi2WO6 , 2010 .

[7]  K. Xu,et al.  Post weaning social isolation influences spatial cognition, prefrontal cortical synaptic plasticity and hippocampal potassium ion channels in Wistar rats , 2010, Neuroscience.

[8]  S. Guterres,et al.  Size-control of poly(epsilon-caprolactone) nanospheres by the interface effect of ethanol on the primary emulsion droplets. , 2009, Journal of nanoscience and nanotechnology.

[9]  N. Oku,et al.  Unique response of zinc in the hippocampus to behavioral stress and attenuation of subsequent mossy fiber long-term potentiation. , 2009, Neurotoxicology.

[10]  D. Pradhan,et al.  Interfacial electronic structure of gold nanoparticles on Si(100): alloying versus quantum size effects. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[11]  Y. Li,et al.  Selection of nutrients for prevention or amelioration of lead-induced learning and memory impairment in rats. , 2009, The Annals of occupational hygiene.

[12]  Tristan Shuman,et al.  Modafinil and memory: effects of modafinil on Morris water maze learning and Pavlovian fear conditioning. , 2009, Behavioral neuroscience.

[13]  Ritesh K Shukla,et al.  DNA damaging potential of zinc oxide nanoparticles in human epidermal cells. , 2009, Toxicology letters.

[14]  Haijiao Zhang,et al.  Nanosized zinc oxide particles induce neural stem cell apoptosis , 2009, Nanotechnology.

[15]  Tao Zhang,et al.  Influences of nanoparticle zinc oxide on acutely isolated rat hippocampal CA3 pyramidal neurons. , 2009, Neurotoxicology.

[16]  J. Roder,et al.  Genetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in mice. , 2008, Learning & memory.

[17]  A. Bhushan,et al.  Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts , 2008, International journal of nanomedicine.

[18]  T. Webster,et al.  Decreased astroglial cell adhesion and proliferation on zinc oxide nanoparticle polyurethane composites , 2008, International journal of nanomedicine.

[19]  Washington Sanchez,et al.  Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo. , 2008, Journal of biomedical optics.

[20]  A. Kirkwood,et al.  Potential Adaptive Function for Altered Long-Term Potentiation Mechanisms in Aging Hippocampus , 2008, The Journal of Neuroscience.

[21]  J. Leite,et al.  Muscarinic acetylcholine neurotransmission enhances the late-phase of long-term potentiation in the hippocampal–prefrontal cortex pathway of rats in vivo: A possible involvement of monoaminergic systems , 2008, Neuroscience.

[22]  Jing Wang,et al.  Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice , 2008 .

[23]  Koh-ich Tanaka,et al.  Effect of acetaminophen, a cyclooxygenase inhibitor, on Morris water maze task performance in mice , 2007, Journal of psychopharmacology.

[24]  David B Warheit,et al.  Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles. , 2007, Toxicological sciences : an official journal of the Society of Toxicology.

[25]  Denise Manahan-Vaughan,et al.  Hippocampal long-term depression: master or minion in declarative memory processes? , 2007, Trends in Neurosciences.

[26]  H. Jeng,et al.  Toxicity of Metal Oxide Nanoparticles in Mammalian Cells , 2006, Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.

[27]  E. Moser,et al.  Spatial representation and the architecture of the entorhinal cortex , 2006, Trends in Neurosciences.

[28]  Y. Auberson,et al.  Zinc Modulates Bidirectional Hippocampal Plasticity by Effects on NMDA Receptors , 2006, The Journal of Neuroscience.

[29]  R. Morris,et al.  Elements of a neurobiological theory of hippocampal function: the role of synaptic plasticity, synaptic tagging and schemas , 2006, The European journal of neuroscience.

[30]  R. Morris.  Developments of a water-maze procedure for studying spatial learning in the rat , 1984, Journal of Neuroscience Methods.

[31]  R. Swain,et al.  Introgression of Brown Norway Chromosome 13 Improves Visual Spatial Memory in the Dahl S Rat , 2010, Behavior genetics.

[32]  Janet Layne,et al.  Preferential killing of cancer cells and activated human T cells using ZnO nanoparticles , 2008, Nanotechnology.

[33]  J. Yuan,et al.  Activation of K+ channels: an essential pathway in programmed cell death. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[34]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .

[35]  M. Kozik,et al.  Morphological and histochemical changes occurring in the brain of rats fed large doses of zinc oxide. , 1980, Folia histochemica et cytochemica.