论文信息 - Evaluation of the Skin Retention Time of Imidazole Derivative/Die Bewertung der Verweildauer von Imidazolderivaten in der Haut

Evaluation of the Skin Retention Time of Imidazole Derivative/Die Bewertung der Verweildauer von Imidazolderivaten in der Haut

Summary: The evaluation of prophylactic antifungal effect expressed as drug retention time, or as time required for the onset of an experimental mycotic infection in pre‐treated guinea‐pigs, has shown some imidazolederivatives capability to exert this activity even 48 and 72 hours after a single application. The long‐term intracutaneous activity and powerful fungicidal activity of one of the tested drug, fenticonazole, suggest that a single daily administration can be adequate for the treatment of human dermatophytosis.

P. Preti | M. Veronese | A. Bertoncini

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