Patient-ventilator interaction.

The respiratory control system consists of a motor arm, which executes the act of breathing, a control centre in the medulla oblongata and a number of pathways that convey information to the control centre. 69 On the basis of this information, the control centre activates spinal motor neurones serving respiratory muscles, with an intensity and rate that can vary substantially between breaths. The activity of spinal motor neurones is carried by peripheral nerves to the respiratory muscles, which contract and generate pressure (Pmus). According to the equation of motion for the respiratory system, Pmus is dissipated to overcome the resistance (Rrs) and elastance (Ers) of the respiratory system (inertia is assumed to be negligible), as follows:

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