TLR2 polymorphisms influence neonatal regulatory T cells depending on maternal atopy

To cite this article: Liu J, Rädler D, Illi S, Klucker E, Turan E, von Mutius E, Kabesch M, Schaub B. TLR2 polymorphisms influence neonatal regulatory T cells depending on maternal atopy. Allergy 2011; 66: 1020–1029.

[1]  Soo-Cheon Chae,et al.  Identification of polymorphisms in the Toll-like receptor gene and the association with allergic rhinitis , 2010, European Archives of Oto-Rhino-Laryngology.

[2]  C. Constantinescu,et al.  Modulation of regulatory T cells in health and disease: role of toll-like receptors. , 2009, Inflammation & allergy drug targets.

[3]  Zihai Li,et al.  Regulatory T cells and Toll-like receptors: what is the missing link? , 2009, International immunopharmacology.

[4]  P. N. Souëf Gene-environmental interaction in the development of atopic asthma: new developments. , 2009 .

[5]  E. von Mutius,et al.  Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. , 2009, The Journal of allergy and clinical immunology.

[6]  N. Klopp,et al.  Rare TLR2 mutations reduce TLR2 receptor function and can increase atopy risk , 2009, Allergy.

[7]  E. von Mutius,et al.  Impairment of T helper and T regulatory cell responses at birth , 2008, Allergy.

[8]  L. Pinto,et al.  Impact of genetics in childhood asthma. , 2008, Jornal de pediatria.

[9]  S. Weiland,et al.  Toll-like receptor heterodimer variants protect from childhood asthma. , 2008, The Journal of allergy and clinical immunology.

[10]  H. Renz,et al.  Dysregulation of toll‐like receptor‐2 (TLR‐2)‐induced effects in monocytes from patients with atopic dermatitis: impact of the TLR‐2 R753Q polymorphism , 2008, Allergy.

[11]  N. Nagelkerke,et al.  Impairment of regulatory T cells in cord blood of atopic mothers. , 2008, The Journal of allergy and clinical immunology.

[12]  K. Heeg,et al.  The Toll-like receptor 2 R753Q mutation modifies cytokine production and Toll-like receptor expression in atopic dermatitis. , 2008, The Journal of allergy and clinical immunology.

[13]  D. Vercelli,et al.  Discovering susceptibility genes for asthma and allergy , 2008, Nature Reviews Immunology.

[14]  Holger Heine,et al.  Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling , 2008, Journal of leukocyte biology.

[15]  Yong Zhao,et al.  Toll‐like receptors and immune regulation: their direct and indirect modulation on regulatory CD4+ CD25+ T cells , 2007, Immunology.

[16]  N. Klopp,et al.  Putative association of a TLR9 promoter polymorphism with atopic eczema , 2007, Allergy.

[17]  D. Kabelitz Expression and function of Toll-like receptors in T lymphocytes. , 2007, Current opinion in immunology.

[18]  N. Klopp,et al.  Lack of association between Toll-like receptor 2 and Toll-like receptor 4 polymorphisms and atopic eczema. , 2006, The Journal of allergy and clinical immunology.

[19]  F. Liew,et al.  Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[20]  E. von Mutius,et al.  The many faces of the hygiene hypothesis. , 2006, The Journal of allergy and clinical immunology.

[21]  E. Lieberman,et al.  Neonatal immune responses to TLR2 stimulation: Influence of maternal atopy on Foxp3 and IL-10 expression , 2006, Respiratory research.

[22]  I. Bellinghausen,et al.  Regulatory activity of human CD4+ CD25+ T cells depends on allergen concentration, type of allergen and atopy status of the donor , 2005, Immunology.

[23]  S. Weiland,et al.  G-Protein-coupled receptor polymorphisms are associated with asthma in a large German population. , 2005, American journal of respiratory and critical care medicine.

[24]  Scott T Weiss,et al.  Cytokines, allergy, and asthma , 2005, Current opinion in allergy and clinical immunology.

[25]  E. Silverman,et al.  TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples. , 2004, American journal of respiratory and critical care medicine.

[26]  D. Nowak,et al.  Toll-like receptor 2 as a major gene for asthma in children of European farmers. , 2004, The Journal of allergy and clinical immunology.

[27]  M. Dallman,et al.  Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease , 2004, The Lancet.

[28]  Charles R Cantor,et al.  A high-throughput gene expression analysis technique using competitive PCR and matrix-assisted laser desorption ionization time-of-flight MS , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[29]  S. Akira,et al.  Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins1 , 2002, The Journal of Immunology.

[30]  M. Wjst,et al.  [European Community Respiratory Health Survey in Adults (ECRHS)]. , 2002, Pneumologie.

[31]  D. Nowak,et al.  Die Europäische Studie zu Atemwegserkrankungen bei Erwachsenen (ECRHS) - Bisherige Ergebnisse und der Beitrag der beiden deutschen Studienzentren - , 2002 .

[32]  S. Akira,et al.  Toll-like receptors: critical proteins linking innate and acquired immunity , 2001, Nature Immunology.

[33]  V. V. D. van der Velden,et al.  Selective development of a strong Th2 cytokine profile in high‐risk children who develop atopy: risk factors and regulatory role of IFN‐γ, IL‐4 and IL‐10 , 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[34]  D. Schwartz,et al.  TLR4 mutations are associated with endotoxin hyporesponsiveness in humans , 2000, Nature Genetics.

[35]  S. Bonini,et al.  Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study , 2000, BMJ : British Medical Journal.

[36]  A. Litonjua,et al.  Parental history and the risk for childhood asthma. Does mother confer more risk than father? , 1998, American journal of respiratory and critical care medicine.

[37]  E. von Mutius,et al.  Impairment of T-regulatory cells in cord blood of atopic mothers. , 2008, The Journal of allergy and clinical immunology.