1J-5 Quantitative Dual-beam Doppler Ultrasound Investigations

The lack of knowledge of the beam-flow angle represents one of the major sources of uncertainty in Doppler measurements. Not only are some new, appealing applications of the Doppler technique prevented, but some basic clinical procedures are made more difficult than desirable. This paper reports on the Doppler angle ambiguity problem and on the classic solutions so far proposed in order to overcome the related limitations. The main features of a recently introduced dual-beam method are described. Starting from the classic problem of measuring the true velocity in a single sample volume, the application to the measurement of full velocity profiles is discussed. Combination of this method with a new multi-channel multi-gate system is shown capable of contributing to arterial mechanics investigations by allowing the simultaneous measurement of wall shear rate and wall distension in major human arteries. Finally the feasibility of accurate volumetric flow measurements is discussed, and work-in-progress is reported

[1]  P. Picot,et al.  Quantitative volume flow estimation using velocity profiles , 1994, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[2]  V. Newhouse,et al.  Ultrasound Doppler Probing of Flows Transverse with Respect to Beam Axis , 1987, IEEE Transactions on Biomedical Engineering.

[3]  C. Atzeni,et al.  Spectral velocity profiles for detailed ultrasound flow analysis , 1996, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[4]  P. Hoskins,et al.  Velocity fluctuation reduction in vector Doppler ultrasound using a hybrid single/dual-beam algorithm , 2003, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[5]  P. Scheel,et al.  Flow velocity and flow volume measurements in the extracranial carotid and vertebral arteries in healthy adults: reference data and the effects of age. , 2000, Ultrasound in medicine & biology.

[6]  T Loupas,et al.  Wall shear stress and related hemodynamic parameters in the fetal descending aorta derived from color Doppler velocity profiles. , 2005, Ultrasound in medicine & biology.

[7]  J. Jensen,et al.  A new method for estimation of velocity vectors , 1998, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[8]  E. Lehmann,et al.  CONFERENCE Elastic properties of the aorta , 1993, The Lancet.

[9]  Sheng Ping Wu,et al.  Wall shear rates differ between the normal carotid, femoral, and brachial arteries: An in vivo MRI study , 2004, Journal of magnetic resonance imaging : JMRI.

[10]  J. Staessen,et al.  Clinical applications of arterial stiffness; definitions and reference values. , 2002, American journal of hypertension.

[11]  R. Reneman,et al.  A radio frequency domain complex cross-correlation model to estimate blood flow velocity and tissue motion by means of ultrasound. , 1997, Ultrasound in medicine & biology.

[12]  Pierre Amarenco,et al.  Flow-mediated vasodilatation of carotid and brachial arteries in healthy subjects and in lacunar stroke patients. , 2006, Ultrasound in medicine & biology.

[13]  Abigail Thrush,et al.  Peripheral vascular ultrasound , 1999 .

[14]  K. Beach,et al.  Cross-beam vector Doppler ultrasound for angle-independent velocity measurements. , 2000, Ultrasound in medicine & biology.

[15]  Piero Tortoli,et al.  Toward a better quantitative measurement of aortic flow. , 2002, Ultrasound in medicine & biology.

[16]  R.S. Reneman,et al.  A Multigate Pulsed Doppler System with Serial Data Processing , 1981, IEEE Transactions on Sonics and Ultrasonics.

[17]  P Peronneau,et al.  Deconvolution process in measurement of arterial velocity profiles via an ultrasonic pulsed Doppler velocimeter for evaluation of the wall shear rate. , 1997, Ultrasound in medicine & biology.

[18]  R S Reneman,et al.  A noninvasive method to estimate wall shear rate using ultrasound. , 1995, Ultrasound in medicine & biology.

[19]  M. O'Donnell,et al.  Quantitative real-time blood flow estimation with intravascular ultrasound in the presence of in-plane flow , 2005, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[20]  Peter R Hoskins,et al.  Angle-independent estimation of maximum velocity through stenoses using vector Doppler ultrasound. , 2003, Ultrasound in medicine & biology.

[21]  P R Hoskins,et al.  A comparison of single- and dual-beam methods for maximum velocity estimation. , 1999, Ultrasound in medicine & biology.

[22]  R. Cobbold,et al.  Comparison of four digital maximum frequency estimators for Doppler ultrasound. , 1988, Ultrasound in medicine & biology.

[23]  R. Reneman,et al.  Non-invasive ultrasound in arterial wall dynamics in humans: what have we learned and what remains to be solved. , 2005, European heart journal.

[24]  A. Gnasso,et al.  Wall Shear Stress Is Associated With Intima-Media Thickness and Carotid Atherosclerosis in Subjects at Low Coronary Heart Disease Risk , 2004, Stroke.

[25]  K. Kohara,et al.  Association Between Risk Factors for Atherosclerosis and Mechanical Forces in Carotid Artery , 2000, Stroke.

[26]  J.T. Powers,et al.  An axial velocity estimator for ultrasound blood flow imaging, based on a full evaluation of the Doppler equation by means of a two-dimensional autocorrelation approach , 1995, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[27]  L.N. Bohs,et al.  A novel method for angle independent ultrasonic imaging of blood flow and tissue motion , 1991, IEEE Transactions on Biomedical Engineering.

[28]  V. L. Newhouse,et al.  Theory of Ultrasound Doppler-Spectra Velocimetry for Arbitrary Beam and Flow Configurations , 1986, IEEE 1986 Ultrasonics Symposium.

[29]  H Handa,et al.  Stiffness and elastic behavior of human intracranial and extracranial arteries. , 1980, Journal of biomechanics.

[30]  D Cathignol,et al.  Assessment of a potentially noninvasive method for monitoring aortic blood flow in children. , 1991, Ultrasound in medicine & biology.

[31]  J. Jensen.  Estimation of Blood Velocities Using Ultrasound: A Signal Processing Approach , 1996 .

[32]  Joanna M Wardlaw,et al.  Which Doppler velocity is best for assessing suitability for carotid endarterectomy? , 2002, European journal of ultrasound : official journal of the European Federation of Societies for Ultrasound in Medicine and Biology.

[33]  A Ross Naylor,et al.  Tissue Doppler imaging of carotid plaque wall motion: a pilot study , 2003, Cardiovascular ultrasound.

[34]  N Bom,et al.  Blood flow imaging and volume flow quantitation with intravascular ultrasound. , 1998, Ultrasound in medicine & biology.

[35]  Piero Tortoli,et al.  Clinical validation of common carotid artery wall distension assessment based on multigate Doppler processing. , 2005, Ultrasound in medicine & biology.

[36]  M. Brandestini.  Topoflow - A digital full range Doppler velocity meter , 1978 .

[37]  P. Stein,et al.  Errors in the estimation of arterial wall shear rates that result from curve fitting of velocity profiles. , 1993, Journal of biomechanics.

[38]  P. Fish,et al.  Velocity bias and fluctuation in the standard dual beam Doppler reconstruction algorithm , 2002, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[39]  C. Vrints,et al.  Flow-mediated vasodilation: a diagnostic instrument, or an experimental tool? , 2005, Chest.

[40]  P Tortoli,et al.  A novel ultrasound instrument for investigation of arterial mechanics. , 2004, Ultrasonics.

[41]  L L Huntsman,et al.  Noninvasive Doppler Determination of Cardiac Output in Man: Clinical Validation , 1983, Circulation.

[42]  Po-Lei Lee,et al.  An improved spectral width Doppler method for estimating Doppler angles in flows with existence of velocity gradients. , 2006, Ultrasound in medicine & biology.

[43]  Kathleen Mullen,et al.  Brachial Artery Elastic Mechanics in Patients With Heart Failure , 2001, Hypertension.

[44]  P Tortoli,et al.  Transverse Doppler spectral analysis for a correct interpretation of flow sonograms. , 1993, Ultrasound in medicine & biology.

[45]  P Tortoli,et al.  Effect of vessel curvature on Doppler derived velocity profiles and fluid flow. , 2005, Ultrasound in medicine & biology.

[46]  Amir Lerman,et al.  Endothelial Dysfunction: A Marker of Atherosclerotic Risk , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[47]  R S Reneman,et al.  Assessment of the distensibility of superficial arteries. , 1990, Ultrasound in medicine & biology.

[48]  P. Tortoli,et al.  Noninvasive simultaneous assessment of wall shear rate and wall distension in carotid arteries. , 2006, Ultrasound in medicine & biology.

[49]  P. Tortoli,et al.  Accurate Doppler angle estimation for vector flow measurements , 2006, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[50]  Piero Tortoli,et al.  Ultrasound Blood Flow Imaging in Carotid Arteries Before and After Endarterectomy , 2004 .

[51]  A Fenster,et al.  Rapid volume flow rate estimation using transverse colour Doppler imaging. , 1995, Ultrasound in medicine & biology.

[52]  H. Kanai,et al.  Real-time measurements of local myocardium motion and arterial wall thickening , 1999, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[53]  A D Hughes,et al.  Inter-individual variations in wall shear stress and mechanical stress distributions at the carotid artery bifurcation of healthy humans. , 2002, Journal of biomechanics.

[54]  P. Tortoli,et al.  Improved blood velocity estimation using the maximum Doppler frequency. , 1995, Ultrasound in medicine & biology.

[55]  W. McDicken,et al.  Doppler Ultrasound: Physics, Instrumentation and Signal Processing , 2000 .

[56]  J. Baker,et al.  A new approach to the noninvasive measurement of cardiac output using an annular array Doppler technique--II. Practical implementation and results. , 1989, Ultrasound in medicine & biology.

[57]  R. Reneman,et al.  An integrated system for the non-invasive assessment of vessel wall and hemodynamic properties of large arteries by means of ultrasound. , 1999, European journal of ultrasound : official journal of the European Federation of Societies for Ultrasound in Medicine and Biology.

[58]  Piero Tortoli,et al.  Interaction between secondary velocities, flow pulsation and vessel morphology in the common carotid artery. , 2003, Ultrasound in medicine & biology.

[59]  P. Tortoli,et al.  P3B-6 A Novel US Method for the Assessment of Maternal, Placental and Fetal Circulation during Pregnancy , 2006, 2006 IEEE Ultrasonics Symposium.

[60]  A. Gnasso,et al.  Association between intima-media thickness and wall shear stress in common carotid arteries in healthy male subjects. , 1996, Circulation.

[61]  P. Hoskins,et al.  Accuracy of maximum velocity estimates made using Doppler ultrasound systems. , 1996, The British journal of radiology.

[62]  D. Ku,et al.  Laser Doppler anemometer measurements of pulsatile flow in a model carotid bifurcation. , 1987, Journal of biomechanics.

[63]  R S Reneman,et al.  Reproducibility of shear rate and shear stress assessment by means of ultrasound in the common carotid artery of young human males and females. , 1997, Ultrasound in medicine & biology.

[64]  K. Kaluzynski,et al.  Effect of method and parameters of spectral analysis on selected indices of simulated Doppler spectra , 2006, Medical and Biological Engineering and Computing.

[65]  R S Reneman,et al.  Wall shear stress in the human common carotid artery as function of age and gender. , 1998, Cardiovascular research.

[66]  Piero Tortoli,et al.  Doppler Ultrasound: Physics Instrumentation and Signal Processing (2nd Edition) , 2001 .

[67]  E D Lehmann.  Elastic properties of the aorta. , 1993, Lancet.

[68]  Å. Ahlgren,et al.  Evaluation of an ultrasonic echo-tracking method for measurements of arterial wall movements in two dimensions , 2005, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.