Events in the Developing Nervous System

Publisher Summary This chapter reviews two developmental mechanisms that play an important role in neurogenesis: migration and massive degeneration of large cell populations. Both processes take place during the early differentiation of the central nervous system and of the sensory ganglia. The capacity of differentiating nerve cells to migrate during the early stages of their differentiation has been known for a long time. However, little has been known about the extent and magnitude of these processes and the role they play in molding nerve centers and wiring them together. The chapter describes one of the most striking instances of massive degenerative processes that take place in the developing spinal cord. It investigates under normal and experimental conditions in the chick embryo that provides a most favorable material for such analysis. The significance of these mechanisms is discussed on the basis of experimentally produced migration and degeneration of nerve cell populations.

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