Therapeutic Applications of Alpha Interferon for Chronic Viral Hepatitis in Pediatric Patients

Hepatitis B virus is a doublestranded DNA virus belonging to the Hepadnavirus family. The only important source of the virus is the reservoir of chronically infected human beings. Approximately 1,500,000 Americans are chronic carriers and 200,000 new cases of HBV infection occur yearly in the United States. More than 10,000 patients are hospitalized each year with hepatitis B and 250 people die each year of fulminant hepatitis. Five thousand individuals die an-

[1]  D. Wang,et al.  [Vertical transmission of hepatitis C virus]. , 1997, Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology.

[2]  V. Kodali,et al.  Levels of hepatitis C virus RNA and liver histology in chronic type C hepatitis. , 1994, The American journal of gastroenterology.

[3]  N. Hayashi,et al.  Serum hepatitis C virus RNA levels and liver injury in volunteer blood donors. , 1994, The American journal of gastroenterology.

[4]  P. Vajro,et al.  Posttransfusion and Community‐Acquired Hepatitis C in Childhood , 1994, Journal of pediatric gastroenterology and nutrition.

[5]  S. Mishiro,et al.  Transmission of Hepatitis C Virus From Mothers to Infants , 1994 .

[6]  B. Fielman,et al.  Interferon-associated refractory status epilepticus. , 1994, Pediatrics.

[7]  P. van Eyken,et al.  Treatment of chronic hepatitis D with interferon alfa-2a. , 1994, The New England journal of medicine.

[8]  S. Jacobs.  Hepatitis B immunization: pediatrician's perspective. , 1994, Pediatrics.

[9]  A. D. Di Bisceglie.  Interferon therapy for chronic viral hepatitis. , 1994, The New England journal of medicine.

[10]  M. Kay,et al.  Alpha interferon therapy in children with chronic active hepatitis B and delta virus infection. , 1993, The Journal of pediatrics.

[11]  J. Prieto,et al.  Prediction of the response of chronic hepatitis C to interferon alfa: a statistical analysis of pretreatment variables. , 1993, Gut.

[12]  R. Lomas.  Hepatitis C: you cannot blame it on your mother. , 1993, The American journal of gastroenterology.

[13]  W. Balistreri,et al.  Hepatitis C virus: implications to pediatric practice , 1993, The Pediatric infectious disease journal.

[14]  N. Hayashi,et al.  Quantitative analysis of hepatitis C virus RNA in serum during interferon alfa therapy. , 1993, Gastroenterology.

[15]  J. Waldon,et al.  Liver function of hepatitis B carriers in childhood. , 1993, The Pediatric infectious disease journal.

[16]  J. Prieto,et al.  Lymphoblastoid alpha-interferon for chronic hepatitis C: a randomized controlled study. , 1993, The American journal of gastroenterology.

[17]  P. Martín,et al.  Exacerbation of psoriasis due to interferon-α treatment of chronic active hepatitis , 1993 .

[18]  G. Masera,et al.  Hepatitis C virus infection and liver disease in children with thalassemia. , 1993, Bone marrow transplantation.

[19]  G. Webster,et al.  Exacerbation of psoriasis due to interferon-alpha treatment of chronic active hepatitis. , 1993, The American journal of gastroenterology.

[20]  K. Shiraki,et al.  Mother-to-infant transmission of hepatitis C virus. , 1993, The Journal of pediatrics.

[21]  H. Alter,et al.  Failure To Detect Vertical Transmission of Hepatitis C Virus , 1992, Annals of Internal Medicine.

[22]  A. Widell,et al.  Mother-to-Infant Transmission of Hepatitis C Virus , 1992, Annals of Internal Medicine.

[23]  A. Maggio,et al.  alpha-Interferon treatment of chronic hepatitis C in young patients with homozygous beta-thalassemia. , 1992, Haematologica.

[24]  M. Puoti,et al.  Hepatitis C virus RNA and antibody response in the clinical course of acute hepatitis C virus infection , 1992, Hepatology.

[25]  V. Carreño,et al.  Treatment of children with chronic hepatitis C with recombinant interferon‐α: A pilot study , 1992, Hepatology.

[26]  A. Alberti,et al.  Hepatitis C viraemia and liver disease in symptom-free individuals with anti-HCV , 1992, The Lancet.

[27]  D. Chan,et al.  Hepatitis B and hepatitis C in emergency department patients. , 1992, The New England journal of medicine.

[28]  J. L. Montagne,et al.  Universal hepatitis B immunization , 1992 .

[29]  P. Pontisso,et al.  Interferon therapy of chronic delta hepatitis in patients cured of pediatric malignancies: possible harmful effect. , 2008, Liver.

[30]  S. Baron,et al.  The interferons. Mechanisms of action and clinical applications. , 1991, JAMA.

[31]  R. Purcell,et al.  A long-term study of hepatitis C virus replication in non-A, non-B hepatitis. , 1991, The New England journal of medicine.

[32]  A. Moreno,et al.  Prospective, randomized controlled trial of interferon‐α in children with chronic hepatitis B , 1991, Hepatology.

[33]  M. Manns,et al.  Autoimmune chronic hepatitis type 2 manifested during interferon therapy in children. , 1991, Journal of hepatology.

[34]  E. Sagnelli,et al.  Prolonged treatment of children with chronic hepatitis B with recombinant alpha 2a-interferon: a controlled, randomized study. , 1991, The American journal of gastroenterology.

[35]  C. Lai,et al.  Effect of recombinant alpha 2 interferon with or without prednisone in Chinese HBsAg carrier children. , 1991, The Quarterly journal of medicine.

[36]  O. Weiland,et al.  Interferon alpha-2b treatment of chronic posttransfusion non-A, non-B/C hepatitis: long-term outcome and effect of increased interferon doses in non-responders. , 1991, Scandinavian journal of infectious diseases.

[37]  A. Moreno,et al.  Prospective, randomized controlled trial of interferon-alpha in children with chronic hepatitis B. , 1991, Hepatology.

[38]  M. Rizzetto,et al.  Treatment with recombinant alpha 2b-interferon of chronic HDV hepatitis in children. , 1991, Progress in clinical and biological research.

[39]  G. Zuccotti,et al.  Maternal-infant transmission of hepatitis C virus and HIV infections: a possible interaction , 1990, The Lancet.

[40]  J. Bartolomé,et al.  A controlled trial of recombinant interferon-alpha in Caucasian children with chronic hepatitis B. , 1990, Digestion.

[41]  E. Schiff,et al.  Treatment of chronic hepatitis C with recombinant alpha-interferon. A multicentre randomized, controlled trial. The Hepatitis Interventional Therapy Group. , 1990, Journal of hepatology.

[42]  Eugene R. Schiff,et al.  Treatment of Chronic Hepatitis C with Recombinant Interferon Alfa , 1989 .

[43]  S. Banks,et al.  Recombinant interferon alfa therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial. , 1989, The New England journal of medicine.

[44]  J. Hoofnagle,et al.  Side Effects of Alpha Interferon , 1989, Seminars in liver disease.

[45]  H. Thomas,et al.  Which patients with chronic hepatitis B virus infection will respond to α‐interferon therapy? A statistical analysis of predictive factors , 1989, Hepatology.

[46]  M. Peters.  Mechanisms of Action of Interferons , 1989, Seminars in liver disease.

[47]  J. Hoofnagle,et al.  Randomized, controlled trial of recombinant human α-interferon in patients with chronic hepatitis B , 1988 .

[48]  S. Cajal,et al.  RECOMBINANT α2-INTERFERON TREATMENT IN CHILDREN WITH CHRONIC HEPATITIS B , 1988, The Lancet.

[49]  J. Hoofnagle,et al.  Randomized, controlled trial of recombinant human alpha-interferon in patients with chronic hepatitis B. , 1988, Gastroenterology.

[50]  C. Lai,et al.  Recombinant alpha 2-interferon treatment in children with chronic hepatitis B. , 1988, Lancet.