Chromium intoxication, with special reference to hepatic injury.

Although chromium compounds have been known for many years to be toxic to various organs of the body, primary hepatic injury has not been a conspicuous clinical finding. The organs most frequently injured by these agents appear to be those that come in direct contact with them, either by external exposure or by excretion, namely, the skin, the mucous membranes, and the kidneys. A variety of surface lesions have been ascribed to contact with soluble chromium compounds. As early as 1827, Cumin 1 described the characteristic "chrome hole" lesions. These occur on exposed parts of the skin, especially the hands, and are punched out, deeply penetrating, painless ulcers. 2 Macular erythema, scarlatinoid and pustular eruptions, and eczematoid lesions of the skin due to contact with these substances have also been reported. 3 Ulceration and perforation of the nasal septum due to inhalation of plating solution fumes have been described frequently.

[1]  C. Camp,et al.  CHROMIUM POISONING IN INFANCY , 1939 .

[2]  F. Gregorius,et al.  Cancer of the respiratory system in the United States chromate producing industry. , 1948, Public health reports.

[3]  M. Goldman,et al.  ACUTE POTASSIUM BICHROMATE POISONING , 1935 .

[4]  H. Joules.  ASTHMA FROM SENSITISATION TO CHROMIUM , 1932 .

[5]  J. J. Bloomfield,et al.  Health Hazards in Chromium Plating. , 2022 .

[6]  H. Brieger.  Zur Klinik der akuten Chromatvergiftung , 1920 .

[7]  Ellis Fa.  Occupational dermatoses in aircraft workers; chromate dermatitis. , 1946 .

[8]  L. Schwartz.  Skin Hazards in American Industry. Part III. , 1940 .

[9]  Brown Ew.  Health hazards from lead paint and zinc chromate paint; incidence in modern construction, maintenance and scrapping of ships. , 1948 .

[10]  H. Popper,et al.  Viral versus toxic hepatic necrosis. , 1948, Archives of pathology.

[11]  E. Letterer,et al.  Chromatlungenkrebs und Chromatstaublunge , 1944 .

[12]  A. H. Johnson,et al.  Chromium toxicology. Absorption of chromium by the rat when milk containing chromium was fed. , 1932 .

[13]  R. Sutton.  Diseases of the Skin , 1929, Glasgow Medical Journal.

[14]  William Cumin.  Remarks on the Medicinal Properties of Madar, and on the Effects of Bichromate of Potass on the Human Body , 1827, Edinburgh medical and surgical journal.

[15]  J. M. Roberts,et al.  Experimental Study of the Effects of Potassium Bichromate on the Monkey's Kidney. , 1933, The American journal of pathology.

[16]  H. Lieberman.  Chrome Ulcerations of the Nose and Throat. , 1941 .

[17]  太田 文雄.  Studies on the Detoxicating Hormone of the Liver (Yakriton):98th Report Contribution to the Usage of Yakriton against Experimental Chromate Nephritis , 1940 .

[18]  N. Zvaifler.  Chromic Acid Poisoning resulting from Inhalation of Mist developed from Five per cent. Chromic Acid Solution. I. Medical Aspects of Chromic Acid Poisoning. , 1944 .

[19]  L. Fairhall,et al.  The Toxicology of Chromium. , 1934 .

[20]  A. F. Hall.  Occupational Contact Dermatitis among Aircraft Workers. , 1944 .