The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels.

[1]  J. Avruch,et al.  Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism* , 1998, The Journal of Biological Chemistry.

[2]  A. Jaeschke,et al.  Mammalian TOR: A Homeostatic ATP Sensor , 2001, Science.

[3]  Thomas A. Steitz,et al.  The involvement of RNA in ribosome function , 2002, Nature.

[4]  K. Inoki,et al.  TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival , 2003, Cell.

[5]  T. Traut,et al.  Physiological concentrations of purines and pyrimidines , 1994, Molecular and Cellular Biochemistry.

[6]  B. Chabner,et al.  Chemotherapy and the war on cancer , 2005, Nature Reviews Cancer.

[7]  J. N. Spelbrink,et al.  Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes , 2007, Nucleic acids research.

[8]  T. P. Neufeld,et al.  Regulation of TORC1 by Rag GTPases in nutrient response , 2008, Nature Cell Biology.

[9]  David M. Sabatini,et al.  The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1 , 2008, Science.

[10]  B. Turk,et al.  AMPK phosphorylation of raptor mediates a metabolic checkpoint. , 2008, Molecular cell.

[11]  Tobias von der Haar,et al.  A quantitative estimation of the global translational activity in logarithmically growing yeast cells , 2008, BMC Systems Biology.

[12]  D. Sabatini,et al.  Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids , 2010, Cell.

[13]  M. V. Vander Heiden,et al.  Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. , 2011, Annual review of cell and developmental biology.

[14]  Martin Kircher,et al.  Deep proteome and transcriptome mapping of a human cancer cell line , 2011, Molecular systems biology.

[15]  B. McManus,et al.  The Human Serum Metabolome , 2011, PloS one.

[16]  P. Finan,et al.  TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. , 2012, Molecular cell.

[17]  D. Hardie,et al.  AMPK: a nutrient and energy sensor that maintains energy homeostasis , 2012, Nature Reviews Molecular Cell Biology.

[18]  U. Sauer,et al.  Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis , 2013, Science.

[19]  O. Kirak,et al.  Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival , 2012, Nature.

[20]  J. Asara,et al.  Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1 , 2013, Science.

[21]  Chien-hung Chen,et al.  Autoregulation of the Mechanistic Target of Rapamycin (mTOR) Complex 2 Integrity Is Controlled by an ATP-dependent Mechanism* , 2013, The Journal of Biological Chemistry.

[22]  D. Hardie,et al.  AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation , 2013, Cell metabolism.

[23]  Matthew Meyerson,et al.  A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1 , 2013, Science.

[24]  B. Manning,et al.  Signal integration by mTORC1 coordinates nutrient input with biosynthetic output , 2013, Nature Cell Biology.

[25]  Sang Gyun Kim,et al.  Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. , 2013, Molecular cell.

[26]  F. Wondisford,et al.  Metformin Activates AMP-activated Protein Kinase by Promoting Formation of the αβγ Heterotrimeric Complex* , 2014, The Journal of Biological Chemistry.

[27]  C. Proud,et al.  mTORC1 signaling controls multiple steps in ribosome biogenesis. , 2014, Seminars in cell & developmental biology.

[28]  L. Cantley,et al.  Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome , 2014, Cell.

[29]  D. Hardie.  AMPK--sensing energy while talking to other signaling pathways. , 2014, Cell metabolism.

[30]  A. Lane,et al.  Regulation of mammalian nucleotide metabolism and biosynthesis , 2015, Nucleic acids research.

[31]  J. Asara,et al.  mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle , 2016, Science.

[32]  R. Deberardinis,et al.  TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions. , 2016, Molecular cell.

[33]  F. Polleux,et al.  AMP-activated protein kinase mediates mitochondrial fission in response to energy stress , 2016, Science.

[34]  I. Ben-Sahra,et al.  mTORC1 signaling and the metabolic control of cell growth. , 2017, Current opinion in cell biology.

[35]  David M. Sabatini,et al.  mTOR Signaling in Growth, Metabolism, and Disease , 2017, Cell.

[36]  R. Abraham,et al.  Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase. , 2017, Cell reports.

[37]  A. González,et al.  Nutrient sensing and TOR signaling in yeast and mammals , 2017, The EMBO journal.