Schizophrenia as a Disorder of Cerebral State Transition*

This paper offers a speculative consideration of the schizophrenic process in the light of recent findings concerning the wave nature of electrocortical activity. These findings indicate that changes of brain state can be described in the terminology of finite-state machines, and both the instantaneous states and the state transitions can be specified. It is suggested that the mental phenomena of schizophrenia may be reducible to events (some specific type of instability) which could be observed by appropriate analytic techniques applied to EEG. Present empirical EEG findings in schizophrenics are reviewed in this light, and the role of dopamine blockade in treatment is also considered.

[1]  H. Stampfer.  Event-Related Potentials in Psychiatry: Approaches to Research and Clinical Applications , 1983, The Australian and New Zealand journal of psychiatry.

[2]  D. Purpura,et al.  Nature of electrocortical potentials and synaptic organizations in cerebral and cerebellar cortex. , 1959, International review of neurobiology.

[3]  J. Leff,et al.  The Influence of Family and Social Factors on the Course of Psychiatric Illness , 1976, British Journal of Psychiatry.

[4]  J. Beaumont,et al.  A critical review of EEG coherence studies of hemisphere function. , 1984, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[5]  D. Lehmann.  Multichannel topography of human alpha EEG fields. , 1971, Electroencephalography and clinical neurophysiology.

[6]  R T Kado,et al.  Electroencephalographic baselines in astronaut candidates estimated by computation and pattern recognition techniques. , 1967, Aerospace medicine.

[7]  F. Duffy,et al.  Brain electrical activity mapping (BEAM) in schizophrenic patients. , 1983, Archives of general psychiatry.

[8]  Norbert Wiener,et al.  Cybernetics. , 1948, Scientific American.

[9]  A. Jablensky,et al.  Two-year follow-up of the patients included in the WHO International Pilot Study of Schizophrenia , 1977, Psychological Medicine.

[10]  Pierre Flor-Henry,et al.  Hemisphere asymmetries of function in psychopathology , 1979 .

[11]  J. Lilly,et al.  Surface movements of figures in spontaneous activity of anesthetized cerebral cortex: leading and trailing edges. , 1955, Journal of neurophysiology.

[12]  P. Dev,et al.  Electrotonic processing of information by brain cells. , 1976, Science.

[13]  T. Crow,et al.  MECHANISM OF THE ANTIPSYCHOTIC EFFECT IN THE TREATMENT OF ACUTE SCHIZOPHRENIA , 1978, The Lancet.

[14]  P. Davis.  EVALUATION OF THE ELECTROENCEPHALOGRAMS OF SCHIZOPHRENIC PATIENTS , 1940 .

[15]  G. McAnulty,et al.  Structure and function: Brain electrical activity mapping and computed tomography in schizophrenia , 1985, Biological Psychiatry.

[16]  Karl H. Pribram,et al.  The Languages of the Brain , 2002 .

[17]  Erol Başar,et al.  Biophysical and physiological systems analysis , 1976 .

[18]  D Giannitrapani.  Spatial organization of the EEG in normal and schizophrenic subjects. , 1979, Electromyography and clinical neurophysiology.

[19]  Benjamin C. Kuo,et al.  AUTOMATIC CONTROL SYSTEMS , 1962, Universum:Technical sciences.

[20]  Small Jg,et al.  RE-EVALUATION OF CLINICAL EEG FINDINGS IN SCHIZOPHRENIA. , 1965 .

[21]  R. Feynman,et al.  The Feynman Lectures on Physics Addison-Wesley Reading , 1963 .

[22]  D O Walter,et al.  Alterations of the human electroencephalogram induced by stressful verbal activity. , 1969, Electroencephalography and clinical neurophysiology.

[23]  D Lehmann,et al.  EEG assessment of brain activity: spatial aspects, segmentation and imaging. , 1984, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[24]  R. Elul.  The genesis of the EEG. , 1971, International review of neurobiology.

[25]  McGillem Cd,et al.  Spectral analysis: prediction and extrapolation. , 1981 .

[26]  S. Bressler,et al.  Shadows of thought: shifting lateralization of human brain electrical patterns during brief visuomotor task. , 1983, Science.

[27]  T. Picton,et al.  Schizophrenia: a neurophysiological evaluation of abnormal information processing. , 1983, Science.

[28]  E. Adrian,et al.  THE BERGER RHYTHM: POTENTIAL CHANGES FROM THE OCCIPITAL LOBES IN MAN , 1934 .

[29]  R. Miller,et al.  Major psychosis and dopamine: controversial features and some suggestions , 1984, Psychological Medicine.

[30]  C. E. SHANNON,et al.  A mathematical theory of communication , 1948, MOCO.

[31]  A S Gevins,et al.  Electrical potentials in human brain during cognition: new method reveals dynamic patterns of correlation. , 1981, Science.

[32]  C. Shagass,et al.  Temporal variability of somatosensory, visual, and auditory evoked potentials in schizophrenia. , 1979, Archives of general psychiatry.

[33]  V. Carr.  Recovery from schizophrenia: a review of patterns of psychosis. , 1983, Schizophrenia bulletin.

[34]  C. Shagass.  An electrophysiological view of schizophrenia. , 1976, Biological psychiatry.

[35]  J. J. Wright,et al.  A preliminary mathematical model for lateral hypothalamic regulation of electrocortical activity. , 1981, Electroencephalography and clinical neurophysiology.

[36]  J. Lilly,et al.  Instantaneous relations between the activities of closely spaced zones on the cerebral cortex; electrical figures during responses and spontaneous activity. , 1954, The American journal of physiology.

[37]  J. Small,et al.  RE-EVALUATION OF CLINICAL EEG FINDINGS IN SCHIZOPHRENIA. , 1965, Diseases of the nervous system.

[38]  T. Itil,et al.  EEG findings in chronic schizophrenics based on digital computer period analysis and analog power spectra. , 1972, Biological psychiatry.

[39]  J. Auñón,et al.  Spectral analysis: prediction and extrapolation. , 1981, Critical reviews in bioengineering.

[40]  J. Stevens,et al.  Telemetered EEG in schizophrenia: spectral analysis during abnormal behaviour episodes. , 1982, Journal of neurology, neurosurgery, and psychiatry.

[41]  John R. Pierce,et al.  Symbols, signals, and noise , 1961 .

[42]  J. J. Wright.  Lateral hypothalamic regulation of electrocortical activity. , 1981, Electroencephalography and clinical neurophysiology.

[43]  P B Fenwick,et al.  Eeg Spectral Analysis in Schizophrenia , 1980, British Journal of Psychiatry.

[44]  Donald O. Walter,et al.  Advances in EEG analysis , 1969 .

[45]  G. Lairy,et al.  Interet pronostique de l'eeg au cours de l'evolution des schizophrenes , 1962 .

[46]  S. Feldman,et al.  Dissociation of Electrocortical Activation and Behavioural Arousal , 1962, Nature.

[47]  C. Shagass,et al.  Relationships between psychiatric diagnosis and some quantitative EEG variables. , 1982, Archives of general psychiatry.

[48]  D. Broadbent.  Perception and communication , 1958 .