Efficient and high accuracy 3-D OCT angiography motion correction in pathology

We describe a novel method for non-rigid 3-D motion correction of orthogonally raster-scanned optical coherence tomography angiography volumes. This is the first approach that aligns predominantly axial structural features such as retinal layers as well as transverse angiographic vascular features in a joint optimization. Combined with orthogonal scanning and favorization of kinematically more plausible displacements, subpixel alignment and micrometer-scale distortion correction is achieved in all 3 dimensions. As no specific structures are segmented, the method is by design robust to pathologic changes. Furthermore, the method is designed for highly parallel implementation and short runtime, allowing its integration into clinical workflow even for high density or wide-field scans. We evaluated the algorithm with metrics related to clinically relevant features in an extensive quantitative evaluation based on 204 volumetric scans of 17 subjects, including patients with diverse pathologies and healthy controls. Using this method, we achieve state-of-the-art axial motion correction and show significant advances in both transverse co-alignment and distortion correction, especially in the subgroup with pathology.

[1]  Martin F. Kraus,et al.  Split-spectrum amplitude-decorrelation angiography with optical coherence tomography , 2012, Optics express.

[2]  Thomas Klein,et al.  High-speed OCT light sources and systems [Invited]. , 2017, Biomedical optics express.

[3]  James G. Fujimoto,et al.  Quantitative 3D-OCT motion correction with tilt and illumination correction, robust similarity measure and regularization , 2014, Biomedical optics express.

[4]  Shuichi Makita,et al.  Three-dimensional eye motion correction by Lissajous scan optical coherence tomography. , 2017, Biomedical optics express.

[5]  Adrian Mariampillai,et al.  Speckle variance detection of microvasculature using swept-source optical coherence tomography. , 2008, Optics letters.

[6]  James G. Fujimoto,et al.  Correction of artifacts from misregistered B-scans in orthogonally scanned and registered OCT angiography , 2019 .

[7]  Joachim Hornegger,et al.  TOWARD QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis , 2016, Retina.

[8]  Wolfgang Wieser,et al.  Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle. , 2015, Biomedical optics express.

[9]  Sina Farsiu,et al.  Handheld simultaneous scanning laser ophthalmoscopy and optical coherence tomography system. , 2013, Biomedical optics express.

[10]  Ruikang K. Wang,et al.  Three dimensional optical angiography. , 2007, Optics express.

[11]  David Huang,et al.  Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology. , 2016, Biomedical optics express.

[12]  A. Fercher,et al.  In vivo human retinal imaging by Fourier domain optical coherence tomography. , 2002, Journal of biomedical optics.

[13]  Gangjun Liu,et al.  Automated motion correction using parallel-strip registration for wide-field en face OCT angiogram. , 2016, Biomedical optics express.

[14]  Shuichi Makita,et al.  Eye-motion-corrected optical coherence tomography angiography using Lissajous scanning. , 2018, Biomedical optics express.

[15]  Alejandro F. Frangi,et al.  Muliscale Vessel Enhancement Filtering , 1998, MICCAI.

[16]  Gangjun Liu,et al.  Automated three-dimensional registration and volume rebuilding for wide-field angiographic and structural optical coherence tomography , 2017, Journal of biomedical optics.

[17]  James G. Fujimoto,et al.  Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns , 2012, Biomedical optics express.

[18]  J. Duker,et al.  Choriocapillaris and Choroidal Microvasculature Imaging with Ultrahigh Speed OCT Angiography , 2013, PloS one.

[19]  James G. Fujimoto,et al.  Hybrid OCT-OCTA Vessel Visualization for Projection-Free Display of the Intermediate and Deep Retinal Plexuses , 2017 .

[20]  Austin Roorda,et al.  Real-time eye motion compensation for OCT imaging with tracking SLO , 2012, Biomedical optics express.

[21]  J. Duker,et al.  Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second. , 2010, Optics express.

[22]  Beop-Min Kim,et al.  Cross-scanning optical coherence tomography angiography for eye motion correction. , 2020, Journal of biophotonics.

[23]  Guillermo Sapiro,et al.  Segmentation guided registration of wide field-of-view retinal optical coherence tomography volumes. , 2016, Biomedical optics express.

[24]  T. Yatagai,et al.  Optical coherence angiography. , 2006, Optics express.

[25]  Raphaël Couturier,et al.  Fine-tuned High-speed Implementation of a GPU-based Median Filter , 2014, J. Signal Process. Syst..

[26]  M. Treder,et al.  Prevalences of segmentation errors and motion artifacts in OCT-angiography differ among retinal diseases , 2018, Graefe's Archive for Clinical and Experimental Ophthalmology.

[27]  Edward Wylęgała,et al.  Optical coherence angiography , 2016, Medicine.

[28]  Lelia Adelina Paunescu,et al.  Tracking optical coherence tomography. , 2004, Optics letters.

[29]  Jens Dreyhaupt,et al.  Quantity and quality of image artifacts in optical coherence tomography angiography , 2019, PloS one.

[30]  Eric Swanson,et al.  The Development, Commercialization, and Impact of Optical Coherence Tomography , 2016, Investigative ophthalmology & visual science.

[31]  Carlo Tomasi,et al.  Automated non-rigid registration and mosaicing for robust imaging of distinct retinal capillary beds using speckle variance optical coherence tomography , 2013, Biomedical optics express.

[32]  Joseph A. Izatt,et al.  Automatic segmentation of seven retinal layers in SDOCT images congruent with expert manual segmentation , 2010, Optics express.

[33]  David Huang,et al.  Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography. , 2013, Biomedical optics express.

[34]  A. M. Kowalczyk,et al.  Phase Retrieval for a Complex-Valued Object Using a Low-Resolution Image , 1990, Signal Recovery and Synthesis III.

[35]  Michael Pircher,et al.  Review on Retrospective Procedures to Correct Retinal Motion Artefacts in OCT Imaging , 2019, Applied Sciences.

[36]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991 .

[37]  D. Hubel,et al.  The role of fixational eye movements in visual perception , 2004, Nature Reviews Neuroscience.

[38]  Yifan Jian,et al.  Strip-based registration of serially acquired optical coherence tomography angiography , 2017, Journal of biomedical optics.

[39]  Mei Chen,et al.  Correcting Motion Artifacts in Retinal Spectral Domain Optical Coherence Tomography via Image Registration , 2009, MICCAI.