Mucosal Biofilm Formation on Middle‐Ear Mucosa in a Nonhuman Primate Model of Chronic Suppurative Otitis Media

Background: An increased awareness of bacterial biofilms and their formation has led to a better understanding of bacterial infections that occur in the middle ear. Perhaps the best studied pathogen for its propensity toward biofilm formation is Pseudomonas aeruginosa, also the primary pathogen in chronic suppurative otitis media (CSOM).

[1]  H. Pillsbury,et al.  Cochlea and Heart as End-Organs in Small Vessel Disease , 1988, The Annals of otology, rhinology, and laryngology.

[2]  C. Sweet.  OTITIS MEDIA IN INFANTS AND CHILDREN. , 1923, California state journal of medicine.

[3]  J. Post,et al.  Candidate's Thesis: Direct Evidence of Bacterial Biofilms in Otitis Media , 2001, The Laryngoscope.

[4]  J. Birchall,et al.  Is otitis media with effusion a biofilm infection? , 2004, Clinical otolaryngology and allied sciences.

[5]  R. Mitchell,et al.  Biofilms and the survival of opportunistic pathogens in recycled water. , 1991, Waste management & research : the journal of the International Solid Wastes and Public Cleansing Association, ISWA.

[6]  W. Doyle,et al.  Treatment of Chronic Suppurative Otitis Media with Topical Ciprofloxacin , 1998, The Annals of otology, rhinology, and laryngology.

[7]  Garth D Ehrlich,et al.  Mucosal biofilm formation on middle-ear mucosa in the chinchilla model of otitis media. , 2002, JAMA.

[8]  P. Hebda,et al.  Treatment of chronic suppurative otitis media with topical tobramycin and dexamethasone. , 2000, Archives of otolaryngology--head & neck surgery.

[9]  M. Kenna.  Microbiology of Chronic Suppurative Otitis Media in Children , 1988 .

[10]  P. Kolenbrander,et al.  Mechanisms of adhesion by oral bacteria. , 1996, Annual review of microbiology.

[11]  J. Costerton,et al.  Optical sectioning of microbial biofilms , 1991, Journal of bacteriology.