3-(3,4,5-Trimethoxyphenyl)-1-oxo-2-propene: a novel pharmacophore displaying potent multidrug resistance reversal and selective cytotoxicity.

[1]  W. Foye,et al.  Principles of medicinal chemistry , 1974 .

[2]  P. Corris,et al.  Oral verapamil with chemotherapy for advanced non-small cell lung cancer: a randomised study. , 1993, British Journal of Cancer.

[3]  Jan Balzarini,et al.  Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones. , 2003, European journal of medicinal chemistry.

[4]  I. Pastan,et al.  Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein. , 1987, The Journal of biological chemistry.

[5]  J. Molnár,et al.  3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells. , 2005, Bioorganic & medicinal chemistry letters.

[6]  Baoxiang Zhao,et al.  Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells. , 2006, Bioorganic & medicinal chemistry letters.

[7]  J. Molnár,et al.  Cinnamylidene ketones as potential modulators of multidrug resistance in mouse lymphoma and human colon cancer cell lines. , 2006, In vivo.

[8]  E. De Clercq,et al.  Cytotoxic and Topographical Properties of 6-Arylidene-2-dimethylaminomethylcyclohexanone Hydrochlorides and Related Compounds , 2004, Journal of enzyme inhibition and medicinal chemistry.

[9]  John H. Block,et al.  Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry , 1991 .

[10]  S. Fujisawa,et al.  Cytotoxic activity of styrylchromones against human tumor cell lines. , 2005, In vivo.

[11]  Palmer Taylor,et al.  Principles of Drug Action , 1990 .

[12]  E. Friedmann Zur Kenntnis der Dihydroresorcine. I. Verseifung der Dihydroresorcincarbonsäureester , 1936 .

[13]  A. Hassner,et al.  The stereochemistry of 2-benzalcyclohexanones and 2-benzalcyclopentanones☆ , 1964 .

[14]  J. Molnár,et al.  Coumarin derivatives with tumor-specific cytotoxicity and multidrug resistance reversal activity. , 2005, In vivo.

[15]  Maria-José U. Ferreira,et al.  Inhibition of multidrug resistance of cancer cells by natural diterpenes, triterpenes and carotenoids. , 2006, Current pharmaceutical design.

[16]  F. Atkins,et al.  Phase I and pharmacokinetic study of the novel MDR1 and MRP1 inhibitor biricodar administered alone and in combination with doxorubicin. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[17]  F. Liu,et al.  A novel kind of nitrogen heterocycle compound induces apoptosis of human chronic myelogenous leukemia K562 cells. , 2006, Bioorganic & medicinal chemistry.

[18]  E. D. Weiler,et al.  cis-trans Isomerism of Exocyclic α,β-Unsaturated Indanones and Tetralones , 1964 .

[19]  T. Myers,et al.  Cytotoxic activities of Mannich bases of chalcones and related compounds. , 1998, Journal of medicinal chemistry.

[20]  T. Miller,et al.  A phase I/II trial of paclitaxel for non‐Hodgkin's lymphoma followed by paclitaxel plus quinine in drug‐resistant disease , 1998, Anti-cancer drugs.

[21]  E. De Clercq,et al.  Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds. , 2006, European journal of medicinal chemistry.

[22]  R. Bukowski,et al.  Phase II trial of doxorubicin and trifluoperazine in metastatic breast cancer , 1993, Investigational New Drugs.

[23]  M. Tsurusawa,et al.  Differential induction of apoptosis on human lymphoblastic leukemia Nalm-6 and Molt-4 cells by various antitumor drugs. , 1997, International journal of hematology.

[24]  A. Jha,et al.  Design, synthesis and biological evaluation of novel curcumin analogues as anti-neoplastic agents , 2006 .

[25]  H. Sakagami,et al.  Effect of anticancer agents on codeinone-induced apoptosis in human cancer cell lines. , 2005, Anticancer research.