Low-power implantable microsystem intended to multichannel cortical recording

We present in this paper an implantable massively parallel cortical data acquisition system. The proposed embedded mixed-signal (analog/digital) processing units are intended to be integrated on one chip, which will be flipped and connected on the top of a microelectrode array. Each channel is composed of a Chopper stabilized (CHS) low-power front-end to remove the 1/f noise, and a mixed-signal compression module using an analog wavelet transform (WT) processor that covers the entire neural signals bandwidth. The proposed front-end is based on a new rail-to-rail preamplifier topology and its circuit simulation under 0.18 /spl mu/m CMOS process demonstrates a power dissipation less than 25 /spl mu/W per channel. The main application of this medical device is to record action potentials evoked by visual stimuli, but it can be useful for several other cortical recording purposes.

[1]  M. Sawan,et al.  CMOS front-end amplifier dedicated to monitor very low amplitude signal from implantable sensors , 2000, Proceedings of the 43rd IEEE Midwest Symposium on Circuits and Systems (Cat.No.CH37144).

[2]  R. J. Vetter,et al.  Silicon-substrate intracortical microelectrode arrays for long-term recording of neuronal spike activity in cerebral cortex , 2003, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[3]  R. Segev,et al.  A method for spike sorting and detection based on wavelet packets and Shannon's mutual information , 2002, Journal of Neuroscience Methods.

[4]  Laurent Baratchart,et al.  Identification d'un filtre hyperfréquences par approximation dans le domaine complexe , 1998 .

[5]  Hao Yu,et al.  Circuitry for a wireless microsystem for neural recording microprobes , 2001, 2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[6]  Gabor C. Temes,et al.  Circuit techniques for reducing the effects of op-amp imperfections: autozeroing, correlated double sampling, and chopper stabilization , 1996, Proc. IEEE.

[7]  Sylvain Martel,et al.  Design and fabrication of a microelectrode array dedicated for cortical electrical stimulation , 2003, CCECE 2003 - Canadian Conference on Electrical and Computer Engineering. Toward a Caring and Humane Technology (Cat. No.03CH37436).