A Multicriteria Model Applied in the Diagnosis of Alzheimer's Disease: A Bayesian Network

This study considers the construction of a multicriteria model to assist in the diagnosis of Alzheimerpsilas disease. Alzheimerpsilas disease is considered the most frequent of the dementias and it is responsible for about 50% of the cases. Due to this fact and the therapeutical limitations in the most advanced stage of the disease, diagnosis of Alzheimerpsilas disease is extremely important and it can provide better life conditions to patients and their families. The main focus of this work is to develop a multicriteria model for aiding in decision making for the diagnosis of Alzheimerpsilas disease, using Bayesian networks as a modeling tool. In this work, the modeling and evaluation processes have been conducted with the aid of a medical expert, bibliographic sources and battery of standardized assessments. The construction of cardinal value scales was implemented through Hiview and Macbeth.

[1]  A. Burns.  Clinical diagnosis of Alzheimer's disease , 1991 .

[2]  B L Holman,et al.  Preclinical prediction of Alzheimer's disease using SPECT , 1998, Neurology.

[3]  K. Davis,et al.  A new rating scale for Alzheimer's disease. , 1984, The American journal of psychiatry.

[4]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[5]  K. Jellinger,et al.  Clinicopathological analysis of dementia disorders in the elderly , 1990, Journal of the Neurological Sciences.

[6]  C. P. Hughes,et al.  A New Clinical Scale for the Staging of Dementia , 1982, British Journal of Psychiatry.

[7]  S. Mirra,et al.  Consortium to Establish a Registry for Alzheimer’s Disease (CERAD): Clinical, neuropsychological, and neuropathological components , 1990, Aging.

[8]  J. Morris,et al.  The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assesment of Alzheimer's disease , 1989, Neurology.

[9]  N Butters,et al.  Detection of abnormal memory decline in mild cases of Alzheimer's disease using CERAD neuropsychological measures. , 1991, Archives of neurology.

[10]  Bruce L. Miller,et al.  Appendix B: Practice parameter: Diagnosis of dementia (an evidence-based review): Report of the quality standards subcommittee of the American academy neurology , 2007 .

[11]  E. Tangalos,et al.  Mild Cognitive Impairment Clinical Characterization and Outcome , 1999 .

[12]  Xiaojie Zhou,et al.  Bayesian estimation of cognitive decline in patients with Alzheimer's disease , 2002 .

[13]  Lynn Kuo,et al.  Bayesian and profile likelihood change point methods for modeling cognitive function over time , 2003, Comput. Stat. Data Anal..

[14]  Herman Buschke,et al.  Diagnosis of early dementia by the Double Memory Test , 1997, Neurology.

[15]  Paul Goodwin,et al.  Decision Analysis for Management Judgment , 1998 .

[16]  Ricardo Nitrini,et al.  Proposta de uma versão brasileira para a escala ADCS-CGIC , 2003 .

[17]  Ricardo Nitrini,et al.  Prevalence of potentially reversible dementias in a dementia outpatient clinic of a tertiary university-affiliated hospital in Brazil. , 2003, Arquivos de neuro-psiquiatria.

[18]  Plácido Rogério Pinheiro,et al.  A Multicriteria Model Applied in the Diagnosis of Alzheimer's Disease: A Bayesian Network , 2008, 2008 11th IEEE International Conference on Computational Science and Engineering.

[19]  C. B. E. Costa,et al.  Facilitating bid evaluation in public call for tenders: a socio-technical approach , 2002 .

[20]  Ricardo Nitrini,et al.  Brazilian version of the Mattis dementia rating scale: diagnosis of mild dementia in Alzheimer's disease. , 2003, Arquivos de neuro-psiquiatria.

[21]  C Jonker,et al.  The diagnostic value of electroencephalography in mild senile Alzheimer's disease , 1999, Clinical Neurophysiology.

[22]  M. Prince,et al.  Predicting the onset of Alzheimer's disease using Bayes' theorem. , 1996, American journal of epidemiology.

[23]  J E Smialek,et al.  Neuropathology of preclinical and clinical lateonset Alzheimer's disease , 1998, Annals of neurology.

[24]  Plácido Rogério Pinheiro,et al.  Applying a Decision Making Model in the Early Diagnosis of Alzheimer's Disease , 2007, RSKT.

[25]  H. Braak,et al.  Neuropathological stageing of Alzheimer-related changes , 2004, Acta Neuropathologica.