Effect of pH-sodium lauryl sulfate combination on solubilization of PG-300995 (an Anti-HIV agent): A technical note

ConclusionSolubilization of PG-300995 has been achieved using SLS at low pH. However, at a pH where both the solute and surfactant are ionized, desolubilization can occur owing to the formation of an insoluble estolate salt. This salt can be solubilized by higher concentrations of SLS.