A selectively deprotectable triazacyclophane scaffold for the construction of artificial receptors.

[reaction: see text]. The synthesis of a triazacylclophane scaffold bearing a set of selectively removable protecting groups is described. This versatile scaffold, which can be linked to a solid support, allows the attachment of three different side chains and can therefore be used for the combinatorial synthesis of libraries of artificial receptor molecules of high structural diversity.

[1]  F. Albericio,et al.  Solid-phase synthesis of 4-aminopiperidine analogues using the Alloc protecting group: an investigation of Alloc removal from secondary amines , 2001 .

[2]  Arwin J. Brouwer,et al.  Bio-inspired synthetic receptor molecules towards mimicry of vancomycin. , 2001, Bioorganic & medicinal chemistry letters.

[3]  T. Opatz,et al.  A facile cleavage of allyl ethers on solid phase , 2000 .

[4]  P. Savage,et al.  Preparation of a protected triamino analogue of cholic acid and sequential incorporation of amino acids in solution and on a solid support. , 2000, Organic letters.

[5]  M. Kodama,et al.  Peptide library based on calix[4]arene , 1999 .

[6]  A. P. Davis,et al.  A trifunctional steroid-based scaffold for combinatorial chemistry , 1999 .

[7]  A. P. Davis,et al.  Steroidal guanidinium receptors for the enantioselective recognition of N-acyl α-amino acids , 1999 .

[8]  C. Férec,et al.  Phosphonolipids as non-viral vectors for gene therapy , 1998 .

[9]  Arwin J. Brouwer,et al.  Tweezers with Different Bite: Increasing the Affinity of Synthetic Receptors by Varying the Hinge Part , 1998 .

[10]  R. Liskamp,et al.  Site-specific N-alkylation of peptides on the solid phase , 1998 .

[11]  M. Honda,et al.  Deprotection of Allyl Groups with Sulfinic Acids and Palladium Catalyst , 1997 .

[12]  P. D. Cook,et al.  Solution Phase Combinatorial Chemistry. Discovery of Novel Polyazapyridinophanes with Potent Antibacterial Activity by a Solution Phase Simultaneous Addition of Functionalities Approach , 1997 .

[13]  T. Scanlan,et al.  Site-Selective N-Methylation of Peptides on Solid Support , 1997 .

[14]  M. Göbel,et al.  Hydrolytical Cleavage of TAR-RNA, the trans -Activation Responsive Region of HIV-1, by a Bis(guanidinium) Catalyst Attached to Arginine , 1996 .

[15]  W. Guba,et al.  The Design and Synthesis of a Scaffold for Combinatorial Chemistry Based on Bile Acid , 1996 .

[16]  C. Walsh,et al.  D-Alanyl-D-alanine ligases and the molecular mechanism of vancomycin resistance , 1992 .

[17]  C. Walsh,et al.  Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci , 1992, Antimicrobial Agents and Chemotherapy.

[18]  D. Landini,et al.  A Convenient Synthesis of N-Alkyl and N, N-Dialkyltrifluoroacetamides in a Solid-liquid Two-Phase System in the Presence of Phase-Transfer Catalysts , 1988 .

[19]  H. Rink.  Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin. , 1987 .

[20]  Dudley H. Williams,et al.  Detailed binding sites of the antibiotics vancomycin and ristocetin A: determination of intermolecular distances in antibiotic/substrate complexes by use of the time-dependent NOE , 1983 .

[21]  Vassilis Dourtoglou,et al.  L'hexafluorophosphate de O-benzotriazolyl-N,N-tetramethyluronium: Un reactif de couplage peptidique nouveau et efficace , 1978 .

[22]  R. Doyle,et al.  Protein-polyelectrolyte interactions. The concanavalin A precipitin reaction with polyelectrolytes and polysaccharide derivatives. , 1968, The Biochemical journal.