Photodynamic Therapy Treatment of Early Oral and Laryngeal Cancers †

Photodynamic therapy (PDT) is a nonsurgical, minimally invasive treatment that uses a light source to activate light‐sensitive drugs or photosensitizers in the treatment of cancer and other diseases. PDT has been successfully employed to treat early carcinomas of the oral cavity and larynx preserving normal tissue and vital functions of speech and swallowing. Two hundred seventy‐six patients with early carcinomas of the oral cavity and larynx were treated from 1990 to 2006. Cure rates with a single treatment for early laryngeal and oral cancers were 91% and 94%, respectively. PDT is an effective primary and alternative treatment modality for early oral cavity and laryngeal cancers.

[1]  P. Speight,et al.  Photodynamic therapy using 5‐aminolevulinic acid for premalignant and malignant lesions of the oral cavity , 1996, Cancer.

[2]  J. Gluckman.  Hematoporphyrin photodynamic therapy: Is there truly a future in head and neck oncology? Reflections on a 5‐year experience , 1991, The Laryngoscope.

[3]  I. Tan,et al.  Meta-tetra(hydroxyphenyl)chlorin photodynamic therapy in early-stage squamous cell carcinoma of the head and neck. , 2003, Archives of otolaryngology--head & neck surgery.

[4]  A. Leunig,et al.  Die photodynamische Lasertherapie im Bereich der Hals-, Nasen-, Ohrenheilkunde* , 1993 .

[5]  V. Schweitzer.  Photodynamic therapy for treatment of head and neck cancer , 1990, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[6]  Photodynamic therapy and the treatment of neoplastic diseases of the larynx , 1994, The Laryngoscope.

[7]  P. Speight,et al.  Photodynamic therapy using mTHPC for malignant disease in the oral cavity , 1997, International journal of cancer.

[8]  M F Mafee,et al.  Photodynamic therapy in the treatment of squamous cell carcinoma of the head and neck. , 1990, Archives of otolaryngology--head & neck surgery.

[9]  James H. Hill,et al.  PHOTODYNAMIC THERAPY OF HEAD and NECK SQUAMOUS CELL CARCINOMA: OPTICAL DOSIMETRY and CLINICAL TRIAL , 1987, Photochemistry and photobiology.

[10]  H. Eckel,et al.  Transoral CO2 Laser for Surgical Management of Glottic Carcinoma in Situ , 2000, The Laryngoscope.

[11]  M. Biel.  Advances in photodynamic therapy for the treatment of head and neck cancers , 2006, Lasers in surgery and medicine.

[12]  C. Hopper,et al.  Treatment of squamous cell carcinoma of the lip using Foscan-mediated photodynamic therapy. , 2001, International journal of oral and maxillofacial surgery.

[13]  Treatment of 570 cases of oral squamous cell carcinoma. , 1989, Annals of the Academy of Medicine, Singapore.

[14]  I. Tan,et al.  mTHPC‐mediated photodynamic therapy for early oral squamous cell carcinoma , 2004, International journal of cancer.

[15]  B. Kulapaditharom,et al.  Photodynamic therapy for residual or recurrent cancer of the nasopharynx. , 1999, Journal of the Medical Association of Thailand = Chotmaihet thangphaet.

[16]  J. Mühling,et al.  Treatment of oral leukoplakia by topical application of 5-aminolevulinic acid. , 1998, International journal of oral and maxillofacial surgery.

[17]  E. Benjamin,et al.  Treatment of primary mucosal head and neck squamous cell carcinoma using photodynamic therapy: results after 25 treated cases , 2003, The Journal of Laryngology & Otology.

[18]  Fu-Yun Zhao,et al.  Use of haematoporphyrin derivative as a sensitizer for radiotherapy of oral and maxillofacial tumours: A preliminary report , 1986, Lasers in Medical Science.

[19]  V. Schweitzer.  PHOTOFRIN‐mediated photodynamic therapy for treatment of early stage oral cavity and laryngeal malignancies * , 2001, Lasers in surgery and medicine.

[20]  J. Feyh,et al.  Photodynamic therapy in head and neck surgery. , 1990, Journal of photochemistry and photobiology. B, Biology.

[21]  P. Speight,et al.  Photodynamic therapy of malignant and premalignant lesions in patients with ’field cancerization‘ of the oral cavity , 1993, The Journal of Laryngology & Otology.

[22]  P. Speight,et al.  Photodynamic therapy of oral cancer: photosensitisation with systemic aminolaevulinic acid , 1993, The Lancet.

[23]  H. Bergh,et al.  Photodynamic therapy for early squamous cell carcinomas of the esophagus, bronchi, and mouth with m-tetra (hydroxyphenyl) chlorin. , 1997, Archives of otolaryngology--head & neck surgery.

[24]  Use of photodynamic therapy in the treatment of vocal cord carcinoma. , 1990, Journal of photochemistry and photobiology. B, Biology.

[25]  R. K. Davis.  Photodynamic therapy in otolaryngology-head and neck surgery. , 1990, Otolaryngologic clinics of North America.

[26]  T. Dougherty,et al.  HOW DOES PHOTODYNAMIC THERAPY WORK? , 1992, Photochemistry and photobiology.

[27]  M. Adamek,et al.  Photodynamic therapy of premalignant lesions and local recurrence of laryngeal and hypopharyngeal cancers , 2001, European Archives of Oto-Rhino-Laryngology.

[28]  M. Biel.  Photodynamic therapy and the treatment of head and neck neoplasia , 1998, The Laryngoscope.

[29]  G. Kenyon,et al.  m-THPC photodynamic therapy for head and neck cancer , 1996, Lasers in Medical Science.