Glial-specific retrovirally mediated gas1 gene expression induces glioma cell apoptosis and inhibits tumor growth in vivo

[1]  Faith Davis,et al.  Brain tumor survival: Results from the National Cancer Data Base , 1998, Journal of Neuro-Oncology.

[2]  J. Naranjo,et al.  Transcriptionally mediated gene targeting of gas1 to glioma cells elicits growth arrest and apoptosis , 2003, Journal of neuroscience research.

[3]  A. Gartel,et al.  Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes. , 2003, Experimental cell research.

[4]  Thomas C Chen,et al.  Highly efficient and tumor-restricted gene transfer to malignant gliomas by replication-competent retroviral vectors. , 2003, Human gene therapy.

[5]  I. Whittle.  Surgery for gliomas , 2002, Current opinion in neurology.

[6]  S. Cory,et al.  Apoptosomes: engines for caspase activation. , 2002, Current opinion in cell biology.

[7]  R. Simon,et al.  Expression, proteolysis and activation of caspases 6 and 7 during rat C6 glioma cell apoptosis , 2002, Neuroscience Letters.

[8]  B. Blazar,et al.  Gene therapy of murine solid tumors with T cells transduced with a retroviral vascular endothelial growth factor--immunotoxin target gene. , 2002, Human gene therapy.

[9]  B. Mellström,et al.  Gas1 Is Induced during and Participates in Excitotoxic Neuronal Death , 2002, Molecular and Cellular Neuroscience.

[10]  F. Shibasaki,et al.  Co-transduction of Apaf-1 and caspase-9 highly enhances p53-mediated apoptosis in gliomas , 2002, British Journal of Cancer.

[11]  C. Fan,et al.  Growth arrest specific gene 1 is a positive growth regulator for the cerebellum. , 2001, Developmental biology.

[12]  S. Srinivasula,et al.  Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter. , 2001, Cancer research.

[13]  C. Schneider,et al.  Functions of the growth arrest specific 1 gene in the development of the mouse embryo. , 2001, Developmental biology.

[14]  M. Scott,et al.  The developmental biology of brain tumors. , 2001, Annual review of neuroscience.

[15]  N. Rainov.  A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. , 2000, Human gene therapy.

[16]  S. Ylä-Herttuala,et al.  Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses. , 2000, Human gene therapy.

[17]  M. E. Ruaro,et al.  The growth suppressing gas1 product is a GPI‐linked protein , 2000, FEBS letters.

[18]  T. Rikiyama,et al.  Inhibition of glioma cells in vitro and in vivo using a recombinant adenoviral vector containing an astrocyte-specific promoter , 2000, Cancer Gene Therapy.

[19]  S. Kyo,et al.  A novel telomerase-specific gene therapy: gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter. , 2000, Human gene therapy.

[20]  G. Walkinshaw,et al.  Therapeutic applications of apoptosis research. , 2000, Experimental cell research.

[21]  S. Orrenius,et al.  Dexamethasone pre-treatment interferes with apoptotic death in glioma cells , 2000, Neuroscience.

[22]  J. Segovia,et al.  Primary astrocytes retrovirally transduced with a tyrosine hydroxylase transgene driven by a glial‐specific promoter elicit behavioral recovery in experimental Parkinsonism , 2000, Journal of neuroscience research.

[23]  L. Mariani,et al.  A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir , 1999 .

[24]  K. Plate,et al.  Retrovirus producer cells encoding antisense VEGF prolong survival of rats with intracranial GS9L gliomas , 1999, International Journal of Developmental Neuroscience.

[25]  K. Frei,et al.  Treatment of experimental glioma by administration of adenoviral vectors expressing Fas ligand. , 1999, Human gene therapy.

[26]  M. Brenner,et al.  Gene therapy in a rodent model of Parkinson's disease using differentiated C6 cells expressing a GFAP-tyrosine hydroxylase transgene. , 1999, Life sciences.

[27]  P. Lowenstein,et al.  Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity. , 1999, The Journal of general virology.

[28]  A. Kyritsis,et al.  Gene therapy for gliomas: p53 and E2F-1 proteins and the target of apoptosis. , 1999, International journal of molecular medicine.

[29]  M. Brenner,et al.  Astrocyte-specific expression of tyrosine hydroxylase after intracerebral gene transfer induces behavioral recovery in experimental Parkinsonism , 1998, Gene Therapy.

[30]  M. Brenner,et al.  Selective killing of glioma cell lines using an astrocyte-specific expression of the herpes simplex virus-thymidine kinase gene. , 1998, Cancer research.

[31]  W. Bielke,et al.  Apoptosis-associated gene expression in the corpus luteum of the rat. , 1998, Biology of reproduction.

[32]  M. Brenner,et al.  Differentiation-dependent expression of transgenes in engineered astrocyte cell lines , 1998, Neuroscience Letters.

[33]  A. Evdokiou,et al.  Tumor‐suppressive activity of the growth arrest‐specific gene GAS1 in human tumor cell lines , 1998, International journal of cancer.

[34]  Z. Ram,et al.  Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells , 1997, Nature Medicine.

[35]  T. Tamiya,et al.  Regression of experimental brain tumors with 6-thioxanthine and Escherichia coli gpt gene therapy. , 1997, Human gene therapy.

[36]  W. Bielke,et al.  Apoptosis in the rat mammary gland and ventral prostate: detection of cell death-associated genes using a coincident-expression cloning approach , 1997, Cell Death and Differentiation.

[37]  S. Orlov,et al.  Swelling-induced activation of Na+,K+,2Cl- cotransport in C6 glioma cells: kinetic properties and intracellular signalling mechanisms. , 1996, Biochimica et biophysica acta.

[38]  M. Westphal,et al.  Adenovirus‐mediated p53 gene transfer suppresses growth of human glioblastoma cells in vitro and in vivo , 1996, International journal of cancer.

[39]  A. Levine,et al.  Gas1-induced growth suppression requires a transactivation-independent p53 function , 1995, Molecular and cellular biology.

[40]  C Haanen,et al.  A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. , 1995, Journal of immunological methods.

[41]  D. Choi-Lundberg,et al.  Ontogeny and distribution of glial cell line-derived neurotrophic factor (GDNF) mRNA in rat. , 1995, Brain research. Developmental brain research.

[42]  A. Tobin,et al.  Cyclic AMP Decreases the Expression of a Neuronal Marker (GAD67) and Increases the Expression of an Astroglial Marker (GFAP) in C6 Cells , 1994, Journal of neurochemistry.

[43]  Z. Ram,et al.  In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. , 1993, Cancer research.

[44]  M. E. Ruaro,et al.  The growth arrest-specific gene, gas1, is involved in growth suppression , 1992, Cell.

[45]  Z. Ram,et al.  In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. , 1992, Science.

[46]  M. Brenner,et al.  Multiple interacting sites regulate astrocyte-specific transcription of the human gene for glial fibrillary acidic protein. , 1991, The Journal of biological chemistry.

[47]  Miller Ad,et al.  Improved Retroviral Vectors for Gene Transfer and Expression , 1989 .

[48]  U. Ruegg,et al.  Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases , 1989 .

[49]  J. Hernandez,et al.  Interaction of cadmium with actin microfilaments in vitro. , 1989, Toxicology in vitro : an international journal published in association with BIBRA.

[50]  Lennart Philipson,et al.  Genes specifically expressed at growth arrest of mammalian cells , 1988, Cell.

[51]  S. Goff,et al.  A safe packaging line for gene transfer: separating viral genes on two different plasmids , 1988, Journal of virology.

[52]  C. Cepko,et al.  Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer. , 1987, Proceedings of the National Academy of Sciences of the United States of America.