The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice

[1]  M. J. Charron,et al.  Loss of glucagon signaling alters white adipose tissue browning , 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[2]  D. Drucker,et al.  Fibroblast activation protein is dispensable for control of glucose homeostasis and body weight in mice , 2018, Molecular metabolism.

[3]  J. Holst,et al.  Insulin Secretion Depends on Intra-islet Glucagon Signaling. , 2018, Cell reports.

[4]  D. Drucker,et al.  Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21 , 2018, Diabetes.

[5]  M. Tschöp,et al.  Targeting the Incretin/Glucagon System With Triagonists to Treat Diabetes , 2018, Endocrine reviews.

[6]  M. Tschöp,et al.  The New Biology and Pharmacology of Glucagon. , 2017, Physiological reviews.

[7]  M. Bednarek,et al.  Robust anti‐obesity and metabolic effects of a dual GLP‐1/glucagon receptor peptide agonist in rodents and non‐human primates , 2016, Diabetes, obesity & metabolism.

[8]  M. Tschöp,et al.  Unimolecular Polypharmacy for Treatment of Diabetes and Obesity. , 2016, Cell metabolism.

[9]  David B. Thomas,et al.  Glucagon increases energy expenditure independently of brown adipose tissue activation in humans , 2015, Diabetes, obesity & metabolism.

[10]  D. Drucker,et al.  Islet α cells and glucagon—critical regulators of energy homeostasis , 2015, Nature Reviews Endocrinology.

[11]  D. D’Alessio,et al.  Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease. , 2015, Physiological reviews.

[12]  R. Seeley,et al.  A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents , 2014, Nature Medicine.

[13]  N. Ozaki,et al.  Glucagon is essential for adaptive thermogenesis in brown adipose tissue. , 2014, Endocrinology.

[14]  S. Woods,et al.  Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions , 2013, Diabetes.

[15]  D. Drucker,et al.  Liver-Specific Disruption of the Murine Glucagon Receptor Produces α-Cell Hyperplasia , 2013, Diabetes.

[16]  A. Pfeiffer,et al.  Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis? , 2013, Diabetologia.

[17]  D. Drucker,et al.  Liver-Speci fi c Disruption of the Murine Glucagon Receptor Produces a -Cell Hyperplasia: Evidence for a Circulating a -Cell Growth Factor , 2012 .

[18]  M. Tschöp,et al.  The metabolic actions of glucagon revisited , 2010, Nature Reviews Endocrinology.

[19]  S. Woods,et al.  Glucagon regulation of energy metabolism , 2010, Physiology & Behavior.

[20]  S. Woods,et al.  A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. , 2009, Nature chemical biology.

[21]  Jiandie D. Lin,et al.  Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. , 2006, Cell metabolism.

[22]  H. Abdelmelek,et al.  Role of catecholamines in glucagon-induced thermogenesis , 2005, Journal of Neural Transmission.

[23]  B. Cannon,et al.  Apparent thermogenic effect of injected glucagon is not due to a direct effect on brown fat cells. , 1998, American journal of physiology. Regulatory, integrative and comparative physiology.

[24]  P. Robberecht,et al.  Relative quantitative analysis of glucagon receptor mRNA in rat tissues , 1994, Molecular and Cellular Endocrinology.

[25]  D. Drucker,et al.  Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. , 1994, Endocrinology.

[26]  D. Atrens,et al.  Glucagon and the paraventricular hypothalamus: modulation of energy balance , 1993, Brain Research.

[27]  F J Grant,et al.  Expression cloning and signaling properties of the rat glucagon receptor. , 1993, Science.

[28]  N. Geary,et al.  Glucagon acts in the liver to control spontaneous meal size in rats. , 1993, The American journal of physiology.

[29]  F. Pi‐Sunyer,et al.  Individual, but not simultaneous, glucagon and cholecystokinin infusions inhibit feeding in men. , 1992, The American journal of physiology.

[30]  D. Atrens,et al.  Insulin and the paraventricular hypothalamus: modulation of energy balance , 1991, Brain Research.

[31]  A. Levine,et al.  Glucagon in physiological concentrations stimulates brown fat thermogenesis in vivo. , 1991, The American journal of physiology.

[32]  P. Schwandt,et al.  Human glucagon and vasoactive intestinal polypeptide (VIP) stimulate free fatty acid release from human adipose tissue in vitro , 1989, Peptides.

[33]  R. Howland,et al.  Modulation by insulin and glucagon of noradrenaline-induced activation of isolated brown adipocytes from the rat. , 1987, European Journal of Biochemistry.

[34]  K. Nair,et al.  Hyperglucagonemia increases resting metabolic rate in man during insulin deficiency. , 1987, The Journal of clinical endocrinology and metabolism.

[35]  J. Morley,et al.  Glucagon stimulation of brown adipose tissue growth and thermogenesis. , 1987, The American journal of physiology.

[36]  Y. Oomura,et al.  Effect of intracerebroventricularly infused glucagon on feeding behavior , 1984, Physiology & Behavior.

[37]  Y. Habara,et al.  Effects of glucagon and noradrenaline on the blood flow through brown adipose tissue in temperature-acclimated rats. , 1983, The Japanese journal of physiology.

[38]  K. Doi,et al.  Thermogenic response to glucagon in cold-acclimated mice. , 1982, The Japanese journal of physiology.

[39]  S. Leichter.  Clinical and Metabolic Aspects of Glucagonoma , 1980, Medicine.

[40]  A. Kuroshima,et al.  Thermogenic responses of brown adipocytes to noradrenaline and glucagon in heat-acclimated and cold-acclimated rats. , 1979, The Japanese journal of physiology.

[41]  T. Heim,et al.  The effect of propranalol on the calorigenic response in brown adipose tissue of new‐born rabbits to catecholamines, glucagon, corticotrophin and cold exposure , 1966, The Journal of physiology.

[42]  C. D. Joel.  Stimulation of metabolism of rat brown adipose tissue by addition of lipolytic hormones in vitro. , 1966, The Journal of biological chemistry.

[43]  D. Steinberg,et al.  EFFECTS OF THE PROSTAGLANDINS ON HORMONE-INDUCED MOBILIZATION OF FREE FATTY ACIDS. , 1964, The Journal of clinical investigation.

[44]  J. H. Hagen.  Effect of glucagon on the metabolism of adipose tissue. , 1961, The Journal of biological chemistry.

[45]  I. Davidson,et al.  The Effect of Glucagon on the Metabolic Rate of Rats , 1960 .

[46]  J. Whitehorn,et al.  Effect of glucagon on food intake and body weight in man. , 1957, Journal of applied physiology.