Prognosis CpG Island Methylator Phenotype – Positive Tumors in the Absence of MLH 1 Methylation Constitute a Distinct Subset of Duodenal Adenocarcinomas and Are Associated with Poor Prognosis

Purpose: Little information is available on genetic and epigenetic changes in duodenal adenocarcinomas. The purpose was to identify possible subsets of duodenal adenocarcinomas based on microsatellite instability (MSI),DNAmethylation,mutations in theKRAS andBRAF genes, clinicopathologic features, and

[1]  Xi Chen,et al.  BVES regulates EMT in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma. , 2011, The Journal of clinical investigation.

[2]  Fang Fang,et al.  Breast Cancer Methylomes Establish an Epigenomic Foundation for Metastasis , 2011, Science Translational Medicine.

[3]  M. Kloor,et al.  Genetics and epigenetics of small bowel adenocarcinoma: the interactions of CIN, MSI, and CIMP , 2011, Modern Pathology.

[4]  J. Herman,et al.  Genomic and Epigenomic Integration Identifies a Prognostic Signature in Colon Cancer , 2011, Clinical Cancer Research.

[5]  N. Cho,et al.  CpG island hypermethylator phenotype in gastric carcinoma and its clinicopathological features , 2010, Virchows Archiv.

[6]  S. Devesa,et al.  Small Intestinal Cancer: a Population-Based Study of Incidence and Survival Patterns in the United States, 1992 to 2006 , 2010, Cancer Epidemiology, Biomarkers & Prevention.

[7]  R. Wilson,et al.  Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. , 2010, Cancer cell.

[8]  R. Palmqvist,et al.  The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status , 2010, Clinical Cancer Research.

[9]  D. Berry,et al.  DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[10]  P. Laird,et al.  Analysis of the Association between CIMP and BRAFV600E in Colorectal Cancer by DNA Methylation Profiling , 2009, PloS one.

[11]  E. Montgomery,et al.  Beta-catenin Nuclear Labeling is a Common Feature of Sessile Serrated Adenomas and Correlates With Early Neoplastic Progression After BRAF Activation , 2009, The American journal of surgical pathology.

[12]  D. Morton,et al.  CpG Island Methylator Phenotype Predicts Progression of Malignant Melanoma , 2009, Clinical Cancer Research.

[13]  P. Laurent-Puig,et al.  Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases. , 2008, Cancer research.

[14]  J. Kleibeuker,et al.  Small-bowel cancer in Lynch syndrome: is it time for surveillance? , 2008, The Lancet. Oncology.

[15]  N. Watanabe,et al.  Identification of Genes Targeted by CpG Island Methylator Phenotype in Neuroblastomas, and Their Possible Integrative Involvement in Poor Prognosis , 2008, Oncology.

[16]  Minoru Toyota,et al.  Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer , 2007, Proceedings of the National Academy of Sciences.

[17]  Michael R. Green,et al.  An elaborate pathway required for Ras-mediated epigenetic silencing , 2007, Nature.

[18]  R. Shaw,et al.  CpG island methylation phenotype (CIMP) in oral cancer: associated with a marked inflammatory response and less aggressive tumour biology. , 2007, Oral oncology.

[19]  Wei Chen,et al.  Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal Cancer , 2007, PLoS genetics.

[20]  M. Loda,et al.  CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations. , 2006, The Journal of molecular diagnostics : JMD.

[21]  B. Christensen,et al.  Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors. , 2006, Cancer research.

[22]  P. Laird,et al.  CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer , 2006, Nature Genetics.

[23]  J. Minna,et al.  Exclusive mutation in epidermal growth factor receptor gene, HER‐2, and KRAS, and synchronous methylation of nonsmall cell lung cancer , 2006, Cancer.

[24]  Xabier Agirre,et al.  Lack of CpG island methylator phenotype defines a clinical subtype of T-cell acute lymphoblastic leukemia associated with good prognosis. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[25]  J. Herman,et al.  CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype. , 2005, Carcinogenesis.

[26]  A. Kaneda,et al.  CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas. , 2005, Cancer research.

[27]  J. Ajani,et al.  Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[28]  N. Matsubara,et al.  Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[29]  Mathew J Garnett,et al.  Guilty as charged: B-RAF is a human oncogene. , 2004, Cancer cell.

[30]  L. Aaltonen,et al.  Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status. , 2004, Human molecular genetics.

[31]  D. Barford,et al.  Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF , 2004, Cell.

[32]  R. Penzel,et al.  Mutational activation of the RAS‐RAF‐MAPK and the wnt pathway in small intestinal adenocarcinomas , 2004, Scandinavian journal of gastroenterology.

[33]  C. Amos,et al.  Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer. , 2003, Cancer research.

[34]  Tsung-Teh Wu,et al.  Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas. , 2003, Gastroenterology.

[35]  R. Ward,et al.  CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. , 2002, Gastroenterology.

[36]  P. Laird,et al.  MethyLight: a high-throughput assay to measure DNA methylation. , 2000, Nucleic acids research.

[37]  R H Hruban,et al.  Hypermethylation of multiple genes in pancreatic adenocarcinoma. , 2000, Cancer research.

[38]  S. Baylin,et al.  Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. , 1999, Cancer research.

[39]  J. Herman,et al.  CpG island methylator phenotype in colorectal cancer. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[40]  H T Lynch,et al.  New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. , 1999, Gastroenterology.

[41]  Y. Fu,et al.  Association of K-ras mutations with p16 methylation in human colon cancer. , 1999, Gastroenterology.

[42]  J. Herman,et al.  Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[43]  J. Rüschoff,et al.  Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression. , 1997, Cancer research.

[44]  J. Herman,et al.  Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[45]  A. Andersson,et al.  Primary carcinoma of the duodenum. , 1980, Annals of surgery.