An Explant Technique for High-Resolution Imaging and Manipulation of Mycobacterial Granulomas

[1]  J. T. Afshari,et al.  Macrophage plasticity, polarization, and function in health and disease , 2018, Journal of cellular physiology.

[2]  H. M. Petrassi,et al.  The Deconstructed Granuloma: A Complex High-Throughput Drug Screening Platform for the Discovery of Host-Directed Therapeutics Against Tuberculosis , 2018, Front. Cell. Infect. Microbiol..

[3]  Pengcheng Bu,et al.  Matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against Mycobacterium tuberculosis , 2018, PLoS pathogens.

[4]  D. Kalman,et al.  In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis , 2017, Proceedings of the National Academy of Sciences.

[5]  M. Zimmerman,et al.  Ethambutol Partitioning in Tuberculous Pulmonary Lesions Explains Its Clinical Efficacy , 2017, Antimicrobial Agents and Chemotherapy.

[6]  M. Chase,et al.  Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis , 2017, mBio.

[7]  G. Schoolnik,et al.  Corrigendum: Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure , 2017, Nature Medicine.

[8]  S. Jogai,et al.  Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model , 2017, eLife.

[9]  Le A. Trinh,et al.  Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection. , 2016, Immunity.

[10]  L. Dodd,et al.  Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure , 2016, Nature Medicine.

[11]  M. Mann,et al.  Inflammatory signaling in human Tuberculosis granulomas is spatially organized , 2016, Nature Medicine.

[12]  M. Zimmerman,et al.  Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice , 2016, ACS infectious diseases.

[13]  Stefan H. Oehlers,et al.  CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections , 2015, Disease Models & Mechanisms.

[14]  J. Harding,et al.  Mycobacterium-Infected Dendritic Cells Disseminate Granulomatous Inflammation , 2015, Scientific Reports.

[15]  R. W. Beerman,et al.  The Macrophage-Specific Promoter mfap4 Allows Live, Long-Term Analysis of Macrophage Behavior during Mycobacterial Infection in Zebrafish , 2015, PloS one.

[16]  Matthew D. Zimmerman,et al.  The association between sterilizing activity and drug distribution into tuberculosis lesions , 2015, Nature Medicine.

[17]  Charles E. Vejnar,et al.  CRISPRscan: designing highly efficient sgRNAs for CRISPR/Cas9 targeting in vivo , 2015, Nature Methods.

[18]  D. Russell,et al.  Trans‐species communication in the Mycobacterium tuberculosis‐infected macrophage , 2015, Immunological reviews.

[19]  C. Barry,et al.  Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses , 2015, Immunological reviews.

[20]  A. Azad,et al.  Characterization of Host and Microbial Determinants in Individuals with Latent Tuberculosis Infection Using a Human Granuloma Model , 2015, mBio.

[21]  N. Katsanis,et al.  Epigenetic control of intestinal barrier function and inflammation in zebrafish , 2015, Proceedings of the National Academy of Sciences.

[22]  Wonsik Lee,et al.  Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment , 2015, PLoS pathogens.

[23]  R. Jain,et al.  Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery , 2015, Proceedings of the National Academy of Sciences.

[24]  L. Dodd,et al.  PET/CT imaging reveals a therapeutic response to oxazolidinones in macaques and humans with tuberculosis , 2014, Science Translational Medicine.

[25]  R. W. Beerman,et al.  Interception of host angiogenic signalling limits mycobacterial growth , 2014, Nature.

[26]  A. Sher,et al.  Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk , 2014, Nature.

[27]  B. Geiger,et al.  The integrin adhesome: from genes and proteins to human disease , 2014, Nature Reviews Molecular Cell Biology.

[28]  I. Macara,et al.  Organization and execution of the epithelial polarity programme , 2014, Nature Reviews Molecular Cell Biology.

[29]  Michael Y. Gerner,et al.  Pathogen-Related Differences in the Abundance of Presented Antigen Are Reflected in CD4+ T Cell Dynamic Behavior and Effector Function in the Lung , 2014, The Journal of Immunology.

[30]  V. Dartois The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells , 2014, Nature Reviews Microbiology.

[31]  Jean-Paul Concordet,et al.  Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair , 2014, Genome research.

[32]  JoAnne L. Flynn,et al.  Sterilization of granulomas is common in both active and latent tuberculosis despite extensive within-host variability in bacterial killing , 2013, Nature Medicine.

[33]  T. Hawn,et al.  Host-Directed Therapeutics for Tuberculosis: Can We Harness the Host? , 2013, Microbiology and Molecular Reviews.

[34]  H. A. Schreiber,et al.  Essential yet limited role for CCR2+ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming , 2013, eLife.

[35]  Jin Hee Kim,et al.  Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms , 2013, The Journal of Immunology.

[36]  L. Ramakrishnan,et al.  Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish , 2013, Nature Protocols.

[37]  T. Parish,et al.  Mycobacterium tuberculosis Responds to Chloride and pH as Synergistic Cues to the Immune Status of its Host Cell , 2013, PLoS pathogens.

[38]  M. Rämet,et al.  Mycobacterium marinum Causes a Latent Infection that Can Be Reactivated by Gamma Irradiation in Adult Zebrafish , 2012, PLoS pathogens.

[39]  L. Ramakrishnan Revisiting the role of the granuloma in tuberculosis , 2012, Nature Reviews Immunology.

[40]  J. Ernst,et al.  Tuberculosis pathogenesis and immunity. , 2012, Annual review of pathology.

[41]  G. Kaplan,et al.  Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response , 2011, Open Biology.

[42]  D. Kalman,et al.  Imatinib-sensitive tyrosine kinases regulate mycobacterial pathogenesis and represent therapeutic targets against tuberculosis. , 2011, Cell host & microbe.

[43]  K. Kaibuchi,et al.  Numb controls E-cadherin endocytosis through p120 catenin with aPKC , 2011, Molecular biology of the cell.

[44]  A. Sher,et al.  Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas. , 2011, Immunity.

[45]  L. Ramakrishnan,et al.  Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism , 2011, Cell.

[46]  A. Andrianopoulos,et al.  mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish. , 2011, Blood.

[47]  L. Zon,et al.  Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish , 2011, Development.

[48]  Xin Xu,et al.  Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice. , 2010, Arthritis and rheumatism.

[49]  U. Schaible,et al.  Optimisation of Bioluminescent Reporters for Use with Mycobacteria , 2010, PloS one.

[50]  David M. Tobin,et al.  The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans , 2010, Cell.

[51]  A. Myers,et al.  Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model. , 2010, Arthritis and rheumatism.

[52]  L. Ramakrishnan,et al.  The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection , 2009, Cell.

[53]  Minjian Chen,et al.  Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death , 2008, The Journal of experimental medicine.

[54]  Hannah E. Volkman,et al.  Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death. , 2008, Immunity.

[55]  Ronald N Germain,et al.  Macrophage and T cell dynamics during the development and disintegration of mycobacterial granulomas. , 2008, Immunity.

[56]  J. Ernst,et al.  Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs , 2008, The Journal of experimental medicine.

[57]  Melissa Hardy,et al.  The Tol2kit: A multisite gateway‐based construction kit for Tol2 transposon transgenesis constructs , 2007, Developmental dynamics : an official publication of the American Association of Anatomists.

[58]  J. Ernst,et al.  Mycobacterium tuberculosis Infects Dendritic Cells with High Frequency and Impairs Their Function In Vivo1 , 2007, The Journal of Immunology.

[59]  J. Guarner,et al.  An in vitro model of the leukocyte interactions associated with granuloma formation in Mycobacterium tuberculosis infection , 2007, Immunology and cell biology.

[60]  D. Born,et al.  Mycobacterium marinum Infection of Adult Zebrafish Causes Caseating Granulomatous Tuberculosis and Is Moderated by Adaptive Immunity , 2006, Infection and Immunity.

[61]  X. Wang,et al.  Harnessing a High Cargo-Capacity Transposon for Genetic Applications in Vertebrates , 2006, PLoS genetics.

[62]  R. Kim,et al.  Mycobacterium marinum Erp Is a Virulence Determinant Required for Cell Wall Integrity and Intracellular Survival , 2006, Infection and Immunity.

[63]  A. Sher,et al.  Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production. , 2005, The Journal of clinical investigation.

[64]  D. Sherman,et al.  Tuberculous Granuloma Formation Is Enhanced by a Mycobacterium Virulence Determinant , 2004, PLoS biology.

[65]  G. Delsol,et al.  An in vitro dual model of mycobacterial granulomas to investigate the molecular interactions between mycobacteria and human host cells , 2004, Cellular microbiology.

[66]  L. Ramakrishnan,et al.  Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos. , 2002, Immunity.

[67]  A. Ben-Ze'ev,et al.  Plakoglobin and beta-catenin: protein interactions, regulation and biological roles. , 2000, Journal of cell science.

[68]  L. Heifets,et al.  Comparison of activities of rifapentine and rifampin against Mycobacterium tuberculosis residing in human macrophages , 1995, Antimicrobial agents and chemotherapy.

[69]  C. Lowenstein,et al.  Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. , 1995, Immunity.

[70]  P. Tulkens Intracellular distribution and activity of antibiotics , 1991, European Journal of Clinical Microbiology and Infectious Diseases.

[71]  D. Adams The structure of mononuclear phagocytes differentiating in vivo. I. Sequential fine and histologic studies of the effect of Bacillus Calmette-Guerin (BCG). , 1974, The American journal of pathology.

[72]  P. Bonventre,et al.  Autoradiographic Evidence for the Impermeability of Mouse Peritoneal Macrophages to Tritiated Streptomycin , 1967, Journal of bacteriology.