Identification of peptides inhibitory to recombinant cysteine proteinase, CPB, of Leishmania mexicana.
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G. H. Coombs | J. Mottram | L. Juliano | M. Juliano | S. Sanderson | M. Meldal | P. S. St Hilaire | L. C. Alves
[1] A. Frasch,et al. The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is encoded by multiple polymorphic tandemly organized genes located on different chromosomes. , 1992, Molecular and biochemical parasitology.
[2] G. H. Coombs,et al. Expression of Cysteine Proteinases by Metacyclic Promastigotes of Leishmania mexicana , 1994, The Journal of eukaryotic microbiology.
[3] R. Ménard,et al. Temperature-dependent substrate inhibition of the cysteine proteinase (GP57/51) from Trypanosoma cruzi. , 1992, Molecular and biochemical parasitology.
[4] L. Juliano,et al. Intramolecularly quenched fluorogenic tetrapeptide substrates for tissue and plasma kallikreins. , 1991, Analytical biochemistry.
[5] Augustine E. Souza,et al. Characterization of a multi‐copy gene for a major stage‐specific cysteine proteinase of Leishmania mexicana , 1992, FEBS letters.
[6] T. Fox,et al. Potent slow-binding inhibition of cathepsin B by its propeptide. , 1992, Biochemistry.
[7] G. H. Coombs,et al. Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a Th1 response. , 1998, Journal of immunology.
[8] J. McKerrow,et al. Development of cysteine protease inhibitors as chemotherapy for parasitic diseases: insights on safety, target validation, and mechanism of action. , 1999, International journal for parasitology.
[9] M. Scott,et al. The prosequence of procaricain forms an alpha-helical domain that prevents access to the substrate-binding cleft. , 1996, Structure.
[10] G. H. Coombs,et al. Characterisation of three groups of cysteine proteinases in the amastigotes of Leishmania mexicana mexicana. , 1990, Molecular and biochemical parasitology.
[11] J. Scharfstein,et al. Inhibition of Trypanosomal Cysteine Proteinases by Their Propeptides* , 1998, The Journal of Biological Chemistry.
[12] L. Juliano,et al. Intramolecularly quenched fluorogenic peptide substrates for human renin. , 1992, Analytical biochemistry.
[13] G. H. Coombs. Proteinases of Leishmania mexicana and other flagellate protozoa , 1982, Parasitology.
[14] G. H. Coombs,et al. A cysteine proteinase cDNA from Trypanosoma brucei predicts an enzyme with an unusual C‐terminal extension , 1989, FEBS letters.
[15] G. H. Coombs,et al. Trypanosomiasis and leishmaniasis : biology and control , 1998 .
[16] G. H. Coombs,et al. Analysis of the roles of cysteine proteinases of Leishmania mexicana in the host–parasite interaction , 2000, Parasitology.
[17] G. H. Coombs,et al. Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions. , 1998, Current opinion in microbiology.
[18] G. H. Coombs,et al. Proteinases of trypanosomes and Leishmania. , 1997 .
[19] G. H. Coombs,et al. Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[20] G. H. Coombs,et al. Multiple high activity cysteine proteases of Leishmania mexicana are encoded by the Imcpb gene array. , 1994, Microbiology.
[21] J. Scharfstein,et al. Structural and functional identification of GP57/51 antigen of Trypanosoma cruzi as a cysteine proteinase. , 1990, Molecular and biochemical parasitology.
[22] J. Scharfstein,et al. Inhibitors of the major cysteinyl proteinase (GP57/51) impair host cell invasion and arrest the intracellular development of Trypanosoma cruzi in vitro. , 1992, Molecular and biochemical parasitology.
[23] A. Barrett,et al. Inhibition of cysteine proteinases and dipeptidyl peptidase I by egg-white cystatin. , 1984, The Biochemical journal.
[24] M. Barrett,et al. Recent advances in identifying and validating drug targets in trypanosomes and leishmanias. , 1999, Trends in microbiology.
[25] G. H. Coombs,et al. Parasite proteinases and amino acid metabolism: possibilities for chemotherapeutic exploitation , 1997, Parasitology.
[26] J. Dalton,et al. The propeptide of Fasciola hepatica cathepsin L is a potent and selective inhibitor of the mature enzyme. , 1999, Molecular and biochemical parasitology.
[27] G. N. Wilkinson. Statistical estimations in enzyme kinetics. , 1961, The Biochemical journal.
[28] R. Coulombe,et al. Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion. , 1996, Structure.
[29] Augustine E. Souza,et al. The Multiple cpb Cysteine Proteinase Genes ofLeishmania mexicana Encode Isoenzymes That Differ in Their Stage Regulation and Substrate Preferences* , 1997, The Journal of Biological Chemistry.
[30] J. Scharfstein,et al. Characterization of the substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi using a portion-mixing combinatorial library and fluorogenic peptides. , 1997, The Biochemical journal.
[31] M. Bogyo,et al. Cysteine protease inhibitors as chemotherapy: lessons from a parasite target. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[32] M. Martino,et al. Inhibition of cathepsin B by its propeptide: Use of overlapping peptides to identify a critical segment , 1996, FEBS letters.
[33] G. H. Coombs,et al. Stage-specific proteinases of Leishmania mexicana mexicana promastigotes. , 1992, FEMS microbiology letters.
[34] D. Turk,et al. Crystal structures of human procathepsin B at 3.2 and 3.3 Å resolution reveal an interaction motif between a papain‐like cysteine protease and its propeptide , 1996, FEBS letters.
[35] G. H. Coombs,et al. Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana. , 2000, The Biochemical journal.
[36] R. Ménard,et al. Potency and selectivity of the cathepsin L propeptide as an inhibitor of cysteine proteases. , 1996, Biochemistry.
[37] S. Nadler,et al. Leishmania major: comparison of the cathepsin L- and B-like cysteine protease genes with those of other trypanosomatids. , 1997, Experimental parasitology.
[38] M. Cygler,et al. Proregion structure of members of the papain superfamily. Mode of inhibition of enzymatic activity. , 1997, Biochimie.
[39] J. McKerrow,et al. Cysteine Protease Inhibitors Cure an Experimental Trypanosoma cruzi Infection , 1998, Journal of Experimental Medicine.
[40] D. Mcmahon-Pratt,et al. Identification of two distinct cysteine proteinase genes of Leishmania pifanoi axenic amastigotes using the polymerase chain reaction. , 1993, Molecular and biochemical parasitology.
[41] G. H. Coombs,et al. The Substrate Specificity of a Recombinant Cysteine Protease from Leishmania mexicana: Application of a Combinatorial Peptide Library Approach , 2000, Chembiochem : a European journal of chemical biology.
[42] G. H. Coombs,et al. Purification and characterization of proteolytic enzymes of Leishmania mexicana mexicana amastigotes and promastigotes. , 1984, Journal of general microbiology.