Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes.
暂无分享,去创建一个
Stephen Neidle | Mekala Gunaratnam | Silvia Sparapani | Filippo Doria | S. Neidle | M. Gunaratnam | S. Haider | F. Doria | Shozeb M Haider | S. Sparapani
[1] J. Fletcher,et al. Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule. , 2009, Journal of medicinal chemistry.
[2] G. Parkinson,et al. Structural basis for binding of porphyrin to human telomeres. , 2007, Biochemistry.
[3] M. Searle,et al. Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat. , 2003, Journal of Molecular Biology.
[4] M. Teulade‐Fichou,et al. A hitchhiker's guide to G-quadruplex ligands. , 2008, Organic & biomolecular chemistry.
[5] Stephen Neidle,et al. Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[6] Markus Wieland,et al. Predictable suppression of gene expression by 5′-UTR-based RNA quadruplexes , 2009, Nucleic acids research.
[7] Julie E Reed,et al. TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules. , 2008, Analytical biochemistry.
[8] Shankar Balasubramanian,et al. G-quadruplexes in promoters throughout the human genome , 2006, Nucleic acids research.
[9] Stephen Neidle,et al. The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. , 2005, Cancer research.
[10] Roger A. Jones,et al. Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization. , 2005, Biochemistry.
[11] N. Oldham,et al. Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures. , 2009, Organic & biomolecular chemistry.
[12] S. Balasubramanian,et al. A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics. , 2009, Journal of the American Chemical Society.
[13] A. Phan,et al. Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution† , 2007, Nucleic acids research.
[14] B. Guyen,et al. Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors. , 2004, Bioorganic & medicinal chemistry letters.
[15] Hamid Morjani,et al. Telomestatin-induced Telomere Uncapping Is Modulated by POT1 through G-overhang Extension in HT1080 Human Tumor Cells* , 2006, Journal of Biological Chemistry.
[16] Stephen Neidle,et al. Molecular dynamics and principal components analysis of human telomeric quadruplex multimers. , 2008, Biophysical journal.
[17] J. Riou,et al. Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands. , 2009, European journal of medicinal chemistry.
[18] Shankar Balasubramanian,et al. An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation. , 2007, Nature chemical biology.
[19] Luke G Green,et al. A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. , 2002, Angewandte Chemie.
[20] K Schulten,et al. VMD: visual molecular dynamics. , 1996, Journal of molecular graphics.
[21] Stephen Neidle,et al. Crystal structure of parallel quadruplexes from human telomeric DNA , 2002, Nature.
[22] Stephen Neidle,et al. Selectivity in ligand recognition of G-quadruplex loops. , 2009, Biochemistry.
[23] Stephen Neidle,et al. Structure of a G-quadruplex-ligand complex. , 2003, Journal of molecular biology.
[24] Roger A. Jones,et al. Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence , 2007, Nucleic acids research.
[25] Carlo Leonetti,et al. Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. , 2007, The Journal of clinical investigation.
[26] M. Franceschin. G‐Quadruplex DNA Structures and Organic Chemistry: More than One Connection , 2009 .
[27] Jeffery T. Davis. G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. , 2004, Angewandte Chemie.
[28] Shankar Balasubramanian,et al. Prevalence of quadruplexes in the human genome , 2005, Nucleic acids research.
[29] Stephen Neidle,et al. Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation. , 2006, Journal of medicinal chemistry.
[30] Yong Xue,et al. Human telomeric DNA forms parallel-stranded intramolecular G-quadruplex in K+ solution under molecular crowding condition. , 2007, Journal of the American Chemical Society.
[31] S. Cogoi,et al. G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription , 2006, Nucleic acids research.
[32] Yu-hua Hao,et al. Molecular crowding creates an essential environment for the formation of stable G-quadruplexes in long double-stranded DNA , 2009, Nucleic acids research.
[33] R. Gartenhaus,et al. Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism , 2007, British Journal of Cancer.
[34] S. Neidle,et al. Inhibition of human telomerase by a G-quadruplex-interactive compound. , 1997, Journal of medicinal chemistry.
[35] S. Neidle,et al. Highly prevalent putative quadruplex sequence motifs in human DNA , 2005, Nucleic acids research.
[36] Stephen Neidle,et al. A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. , 2006, Biochemistry.
[37] Stephen Neidle,et al. Mechanism of acridine-based telomerase inhibition and telomere shortening. , 2007, Biochemical pharmacology.
[38] S. Balasubramanian,et al. Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands. , 2007, Journal of the American Chemical Society.
[39] J. Mergny,et al. Thermal melting studies of ligand DNA interactions. , 2010, Methods in molecular biology.
[40] M. Vorlíčková,et al. Arrangements of human telomere DNA quadruplex in physiologically relevant K+ solutions , 2009, Nucleic acids research.
[41] A. Phan,et al. Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter , 2005, Nature chemical biology.
[42] I. Willner,et al. Cover Picture: Increasing the Complexity of Periodic Protein Nanostructures by the Rolling‐Circle‐Amplified Synthesis of Aptamers (Angew. Chem. Int. Ed. 1/2008) , 2008 .
[43] D. Bearss,et al. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[44] David M. Prescott,et al. Inhibition of telomerase by G-quartet DMA structures , 1991, Nature.
[45] Roger A. Jones,et al. Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution , 2006, Nucleic acids research.
[46] Nathan A. Baker,et al. Electrostatics of nanosystems: Application to microtubules and the ribosome , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[47] S. Neidle,et al. A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes. , 2009, Biochemical Society transactions.
[48] P. Dumy,et al. Synthesis and evaluation of fused bispyrimidinoacridines as novel pentacyclic analogues of quadruplex-binder BRACO-19. , 2009, Organic & biomolecular chemistry.
[49] Stephen Neidle,et al. Putative DNA quadruplex formation within the human c-kit oncogene. , 2005, Journal of the American Chemical Society.
[50] N. Luedtke,et al. pH-mediated fluorescence and G-quadruplex binding of amido phthalocyanines. , 2010, Biochemistry.
[51] S. Neidle,et al. A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. , 2002, Molecular pharmacology.
[52] Sarah W. Burge,et al. Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. , 2007, Journal of the American Chemical Society.
[53] S. Balasubramanian,et al. G-quadruplex nucleic acids as therapeutic targets. , 2009, Current opinion in chemical biology.
[54] B. Pagano,et al. Shedding light on the interaction between TMPyP4 and human telomeric quadruplexes. , 2009, The journal of physical chemistry. B.
[55] X. Qu,et al. Small-molecule selectively recognizes human telomeric G-quadruplex DNA and regulates its conformational switch. , 2009, Biophysical journal.
[56] A. Phan,et al. Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter. , 2004, Journal of the American Chemical Society.
[57] Jinguo Huang,et al. Bis(benzimidazole)pyridine derivative as a new class of G-quadruplex inducing and stabilizing ligand. , 2008, Chemical communications.
[58] Sarah W. Burge,et al. Quadruplex DNA: sequence, topology and structure , 2006, Nucleic acids research.
[59] A. W. Czarnik,et al. Nitrosations in Anhydrous Trifluoroacetic Acid Media: A Modification for Insoluble or Deactivated Amine and Amide Precursors , 1988 .
[60] G. Parkinson,et al. Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes. , 2008, Journal of molecular biology.
[61] Jia-Heng Tan,et al. Design of selective G-quadruplex ligands as potential anticancer agents. , 2008, Mini reviews in medicinal chemistry.
[62] Stephen Neidle,et al. Structural basis of DNA quadruplex recognition by an acridine drug. , 2008, Journal of the American Chemical Society.
[63] B. Keppler,et al. BRACO19 analog dimers with improved inhibition of telomerase and hPot 1. , 2009, Bioorganic & medicinal chemistry.
[64] A. Phan,et al. Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers. , 2009, Journal of the American Chemical Society.
[65] S. Neidle,et al. Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry. , 2006, Journal of the American Chemical Society.
[66] C. Hodgman,et al. Repression of translation of human estrogen receptor alpha by G-quadruplex formation. , 2009, Biochemistry.