Title When does brain aging accelerate ? Dangers of quadratic fits in cross-sectional studies

[1]  L. Berg.  Clinical Dementia Rating (CDR). , 1988, Psychopharmacology bulletin.

[2]  Atle Bjørnerud,et al.  Error-related negativity is mediated by fractional anisotropy in the posterior cingulate gyrus--a study combining diffusion tensor imaging and electrophysiology in healthy adults. , 2009, Cerebral cortex.

[3]  Daniel H. Mathalon,et al.  Age-related decline in MRI volumes of temporal lobe gray matter but not hippocampus , 1995, Neurobiology of Aging.

[4]  A. Dale,et al.  Whole Brain Segmentation Automated Labeling of Neuroanatomical Structures in the Human Brain , 2002, Neuron.

[5]  John G. Csernansky,et al.  Open Access Series of Imaging Studies (OASIS): Cross-sectional MRI Data in Young, Middle Aged, Nondemented, and Demented Older Adults , 2007, Journal of Cognitive Neuroscience.

[6]  E. Yeterian,et al.  MRI-Based Topographic Parcellation of Human Cerebral White Matter and Nuclei II. Rationale and Applications with Systematics of Cerebral Connectivity , 1999, NeuroImage.

[7]  N. Raz,et al.  Aging white matter and cognition: Differential effects of regional variations in diffusion properties on memory, executive functions, and speed , 2009, Neuropsychologia.

[8]  L. Westlye,et al.  Brain maturation in adolescence and young adulthood: regional age-related changes in cortical thickness and white matter volume and microstructure. , 2010, Cerebral cortex.

[9]  H. Muller.  Kernel estimators of zeros and of location and size of extrema of regression functions , 1985 .

[10]  Terry L. Jernigan,et al.  Changes in volume with age—consistency and interpretation of observed effects , 2005, Neurobiology of Aging.

[11]  James R. MacFall,et al.  Aging, gender, and the elderly adult brain: An examination of analytical strategies , 2008, Neurobiology of Aging.

[12]  Xiao Han,et al.  Atlas Renormalization for Improved Brain MR Image Segmentation Across Scanner Platforms , 2007, IEEE Transactions on Medical Imaging.

[13]  R. Woods,et al.  Sex differences in cortical thickness mapped in 176 healthy individuals between 7 and 87 years of age. , 2007, Cerebral cortex.

[14]  Anders M. Dale,et al.  Sequence-independent segmentation of magnetic resonance images , 2004, NeuroImage.

[15]  Anders M. Dale,et al.  Consistent neuroanatomical age-related volume differences across multiple samples , 2011, Neurobiology of Aging.

[16]  M Skalej,et al.  Patterns of age-related shrinkage in cerebellum and brainstem observed in vivo using three-dimensional MRI volumetry. , 1999, Cerebral cortex.

[17]  A. Dale,et al.  High consistency of regional cortical thinning in aging across multiple samples. , 2009, Cerebral cortex.

[18]  Faith M. Gunning-Dixon,et al.  Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: replicability of regional differences in volume , 2004, Neurobiology of Aging.

[19]  Arthur F. Kramer,et al.  Age-related differences in regional brain volumes: A comparison of optimized voxel-based morphometry to manual volumetry , 2009, Neurobiology of Aging.

[20]  Karl J. Friston,et al.  A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains , 2001, NeuroImage.

[21]  Jianqing Fan,et al.  Generalized likelihood ratio statistics and Wilks phenomenon , 2001 .

[22]  Wolfgang Härdle,et al.  Applied Nonparametric Regression: The kernel method , 1990 .

[23]  C. Petten.  Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan: review and meta-analysis , 2004, Neuropsychologia.

[24]  Abraham Z. Snyder,et al.  A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability and validation against manual measurement of total intracranial volume , 2004, NeuroImage.

[25]  L. Berg,et al.  Clinical Dementia Rating , 1984, British Journal of Psychiatry.

[26]  Geraldo F. Busatto,et al.  Age-related gray matter volume changes in the brain during non-elderly adulthood , 2011, Neurobiology of Aging.

[27]  J. Townsend,et al.  Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers. , 2000, Radiology.

[28]  N. Schuff,et al.  Age effects on atrophy rates of entorhinal cortex and hippocampus , 2006, Neurobiology of Aging.

[29]  Suzanne E. Welcome,et al.  Mapping cortical change across the human life span , 2003, Nature Neuroscience.

[30]  A. Dale,et al.  Effects of age on volumes of cortex, white matter and subcortical structures , 2005, Neurobiology of Aging.

[31]  John S. Allen,et al.  Normal neuroanatomical variation due to age: The major lobes and a parcellation of the temporal region , 2005, Neurobiology of Aging.

[32]  Anders M. Dale,et al.  Volumetric cerebral characteristics of children exposed to opiates and other substances in utero , 2007, NeuroImage.

[33]  Robert Andersen.  Nonparametric Methods for Modeling Nonlinearity in Regression Analysis , 2009 .

[34]  André J. W. van der Kouwe,et al.  The relationship between diffusion tensor imaging and volumetry as measures of white matter properties , 2008, NeuroImage.

[35]  Jens C. Pruessner,et al.  Hippocampal volume is as variable in young as in older adults: Implications for the notion of hippocampal atrophy in humans , 2007, NeuroImage.