Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease
暂无分享,去创建一个
R. Kayed | C. Glabe | D. Cribbs | Jun Zhou | S. Webster | M. Fonseca | A. Tenner | Irma Hernandez | O. Yazan
[1] T. D. Pugh,et al. Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging , 2005, Science.
[2] W. K. Cullen,et al. Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo , 2005, Nature Medicine.
[3] J. D. McGaugh,et al. Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice , 2005, Neuron.
[4] W. H. Jordan,et al. Exacerbation of Cerebral Amyloid Angiopathy-Associated Microhemorrhage in Amyloid Precursor Protein Transgenic Mice by Immunotherapy Is Dependent on Antibody Recognition of Deposited Forms of Amyloid β , 2005, The Journal of Neuroscience.
[5] L. Jenkins,et al. Evaluation of the safety and immunogenicity of synthetic Aβ42 (AN1792) in patients with AD , 2005, Neurology.
[6] T. Golde,et al. The Aβ Hypothesis: Leading Us to Rationally‐Designed Therapeutic Strategies for the Treatment or Prevention of Alzheimer Disease , 2005, Brain pathology.
[7] D. Wilcock,et al. Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage , 2004, Journal of Neuroinflammation.
[8] P. Seubert,et al. Current progress in beta-amyloid immunotherapy. , 2004, Current opinion in immunology.
[9] Stuart Maudsley,et al. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders , 2004, Trends in Neurosciences.
[10] David H. Cribbs,et al. Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome , 2004, Neuron.
[11] Peter J. Lenting,et al. LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms , 2004, Neuron.
[12] Jun Zhou,et al. Absence of C1q Leads to Less Neuropathology in Transgenic Mouse Models of Alzheimer's Disease , 2004, The Journal of Neuroscience.
[13] D. Quartermain,et al. An Attenuated Immune Response Is Sufficient to Enhance Cognition in an Alzheimer's Disease Mouse Model Immunized with Amyloid-β Derivatives , 2004, The Journal of Neuroscience.
[14] D. Wilcock,et al. Passive Amyloid Immunotherapy Clears Amyloid and Transiently Activates Microglia in a Transgenic Mouse Model of Amyloid Deposition , 2004, The Journal of Neuroscience.
[15] B. Zlokovic. Clearing amyloid through the blood–brain barrier , 2004, Journal of neurochemistry.
[16] John D Lambris,et al. Novel monoclonal antibodies against mouse C3 interfering with complement activation: description of fine specificity and applications to various immunoassays. , 2004, Molecular immunology.
[17] I. Ferrer,et al. Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease , 2004, Brain pathology.
[18] D. Selkoe,et al. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. , 2003, Annual review of pharmacology and toxicology.
[19] D. Holtzman,et al. Evidence for peripheral clearance of cerebral Aβ protein following chronic, active Aβ immunization in PSAPP mice , 2003, Neurobiology of Disease.
[20] D. Dickson,et al. Amyloid-β Immunization Effectively Reduces Amyloid Deposition in FcRγ-/- Knock-Out Mice , 2003, The Journal of Neuroscience.
[21] B. Dubois,et al. Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization , 2003, Neurology.
[22] C. Lemere,et al. Amyloid-Beta Immunization in Alzheimer's Disease Transgenic Mouse Models and Wildtype Mice , 2003, Neurochemical Research.
[23] D. Diamond,et al. Short-term β-amyloid vaccinations do not improve cognitive performance in cognitively impaired APP+PS1 mice , 2003 .
[24] P. Mcgeer,et al. Is there a future for vaccination as a treatment for Alzheimer’s disease? , 2003, Neurobiology of Aging.
[25] Dave Morgan,et al. Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation , 2003, The Journal of Neuroscience.
[26] Carl W. Cotman,et al. Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis , 2003, Science.
[27] C. Holmes,et al. Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report , 2003, Nature Medicine.
[28] R. Motter,et al. Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[29] G. Comi,et al. Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice. , 2003, Brain : a journal of neurology.
[30] D. Holtzman,et al. Aβ immunization and anti-Aβ antibodies: potential therapies for the prevention and treatment of Alzheimer’s disease , 2002 .
[31] E. Masliah,et al. Increased Extracellular Amyloid Deposition and Neurodegeneration in Human Amyloid Precursor Protein Transgenic Mice Deficient in Receptor-Associated Protein , 2002, The Journal of Neuroscience.
[32] W. Klein. Aβ toxicity in Alzheimer’s disease: globular oligomers (ADDLs) as new vaccine and drug targets , 2002, Neurochemistry International.
[33] A. Cuello,et al. Intracellular A-beta amyloid, A sign for worse things to come? , 2002, Molecular Neurobiology.
[34] B. Hyman,et al. Non-Fc-Mediated Mechanisms Are Involved in Clearance of Amyloid-β In Vivo by Immunotherapy , 2002, The Journal of Neuroscience.
[35] B. Hyman,et al. Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease , 2002, The Journal of Neuroscience.
[36] Xin Wu,et al. Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model , 2002, Nature Neuroscience.
[37] W. K. Cullen,et al. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo , 2002, Nature.
[38] Brett Chromy,et al. Soluble oligomers of β amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus , 2002, Brain Research.
[39] F. Aloisi. Immune function of microglia , 2001, Glia.
[40] S. Younkin,et al. Reduced effectiveness of Aβ1-42 immunization in APP transgenic mice with significant amyloid deposition , 2001, Neurobiology of Aging.
[41] David J. Cummins,et al. Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[42] C. Lemere,et al. Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease. , 2001, The American journal of pathology.
[43] J. Hardy,et al. Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease , 2000, Nature.
[44] Ralph A. Nixon,et al. Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease , 2000, Nature.
[45] D. Holtzman,et al. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. , 2000, The Journal of clinical investigation.
[46] P. Mathews,et al. The Endosomal-Lysosomal System of Neurons in Alzheimer's Disease Pathogenesis: A Review , 2000, Neurochemical Research.
[47] R. Motter,et al. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease , 2000, Nature Medicine.
[48] R. Motter,et al. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse , 1999, Nature.
[49] S. Gauthier,et al. β-Amyloid precursor protein is detectable on monocytes and is increased in Alzheimer’s disease , 1999, Neurobiology of Aging.
[50] B. Bradt,et al. Complement-dependent Proinflammatory Properties of the Alzheimer's Disease β-Peptide , 1998, Journal of Experimental Medicine.
[51] T. Morgan,et al. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[52] S. Younkin,et al. Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice , 1996, Science.
[53] C. Glabe,et al. Intracellular Aβ1-42 Aggregates Stimulate the Accumulation of Stable, Insoluble Amyloidogenic Fragments of the Amyloid Precursor Protein in Transfected Cells (*) , 1995, The Journal of Biological Chemistry.
[54] C. Cotman,et al. beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. , 1994, Journal of immunology.
[55] P. Mcgeer,et al. Complement activation by beta-amyloid in Alzheimer disease. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[56] M. Bewick,et al. EFFECT OF GRAFT PERFUSION WITH TWO CD45 MONOCLONAL ANTIBODIES ON INCIDENCE OF KIDNEY ALLOGRAFT REJECTION , 1989, The Lancet.
[57] T. Springer,et al. Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: structure-function assessments employing subunit-specific monoclonal antibodies. , 1986, Journal of immunology.
[58] G. Viale,et al. Glial fibrillary acidic protein immunoreactivity in normal and diseased human breast , 2005, Virchows Archiv A.
[59] W. K. Cullen,et al. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. , 2005, Nature medicine.
[60] R. Deane,et al. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. , 2004, Neuron.
[61] R. Mrak,et al. Microglia and neuroinflammation: a pathological perspective , 2004 .
[62] D. Diamond,et al. Short-term beta-amyloid vaccinations do not improve cognitive performance in cognitively impaired APP + PS1 mice. , 2003, Behavioral neuroscience.
[63] D. Dickson,et al. Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice. , 2003, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[64] D. Holtzman,et al. Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice. , 2003, Neurobiology of disease.
[65] D. Wilcock,et al. Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation. , 2003, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[66] W Blaine Stine,et al. Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus. , 2002, Brain research.
[67] D. Holtzman,et al. Abeta immunization and anti-Abeta antibodies: potential therapies for the prevention and treatment of Alzheimer's disease. , 2002, Advanced drug delivery reviews.
[68] D. Holtzman,et al. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[69] J. Hardy,et al. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. , 2000, Nature.
[70] P. S. St George-Hyslop,et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. , 2000, Nature.
[71] S. Gauthier,et al. Beta-amyloid precursor protein is detectable on monocytes and is increased in Alzheimer's disease. , 1999, Neurobiology of aging.
[72] H. Levine. Quantification of beta-sheet amyloid fibril structures with thioflavin T. , 1999, Methods in enzymology.
[73] T. Fleisher,et al. Immune function. , 1997, Pediatrics in review.