Assessing liver function using dynamic Gd‐EOB‐DTPA‐enhanced MRI with a standard 5‐phase imaging protocol

To evaluate liver function obtained by tracer‐kinetic modeling of dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) data acquired with a routine gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA)‐enhanced protocol.

[1]  A K Dixon,et al.  Functional images of hepatic perfusion obtained with dynamic CT. , 1993, Radiology.

[2]  M. Mack,et al.  Liver tumors: comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA. , 1996, Radiology.

[3]  A. Nordell,et al.  Assessment of liver function in primary biliary cirrhosis using Gd-EOB-DTPA-enhanced liver MRI. , 2010, HPB : the official journal of the International Hepato Pancreato Biliary Association.

[4]  P. Bedossa,et al.  Age and platelet count: a simple index for predicting the presence of histological lesions in patients with antibodies to hepatitis C virus , 1997, Journal of viral hepatitis.

[5]  R Materne,et al.  Hepatic perfusion parameters in chronic liver disease: dynamic CT measurements correlated with disease severity. , 2001, AJR. American journal of roentgenology.

[6]  G. Schuhmann-Giampieri.  Liver contrast media for magnetic resonance imaging. Interrelations between pharmacokinetics and imaging. , 1993, Investigative radiology.

[7]  Robert Luypaert,et al.  Validity of perfusion parameters obtained using the modified Tofts model: A simulation study , 2011, Magnetic resonance in medicine.

[8]  A. Mehrabi,et al.  Quantification of liver perfusion by dynamic magnetic resonance imaging: Experimental evaluation and clinical pilot study , 2009, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[9]  Y. Onodera,et al.  Separate analysis of asialoglycoprotein receptors in the right and left hepatic lobes using 99mTc‐GSA SPECT , 2003, Hepatology.

[10]  Jørgen Frøkiær,et al.  Quantitation of differential renal blood flow and renal function using dynamic contrast‐enhanced MRI in rats , 2004, Magnetic resonance in medicine.

[11]  M. Schwartz,et al.  Liver functional reserve estimation: state of the art and relevance for local treatments , 2010, Journal of hepato-biliary-pancreatic sciences.

[12]  Yongmin Chang,et al.  Quantitative Evaluation of Liver Function with MRI Using Gd-EOB-DTPA , 2004, Korean journal of radiology.

[13]  B. V. Van Beers,et al.  Hepatic flow parameters measured with MR imaging and Doppler US: correlations with degree of cirrhosis and portal hypertension. , 2003, Radiology.

[14]  M. Reiser,et al.  Combined quantification of liver perfusion and function with dynamic gadoxetic acid-enhanced MR imaging. , 2012, Radiology.

[15]  D. Schuppan,et al.  Prognosis of a large cohort of patients with hepatocellular carcinoma in a single European centre. , 2002, Liver.

[16]  C. Thng,et al.  Dynamic contrast-enhanced CT imaging of hepatocellular carcinoma in cirrhosis: feasibility of a prolonged dual-phase imaging protocol with tracer kinetics modeling , 2009, European Radiology.

[17]  C. Sempoux,et al.  Capillarization of the sinusoids in liver fibrosis: Noninvasive assessment with contrast‐enhanced MRI in the rabbit , 2003, Magnetic resonance in medicine.

[18]  A. Nordell,et al.  Assessment of hepatic extraction fraction and input relative blood flow using dynamic hepatocyte‐specific contrast‐enhanced MRI , 2009, Journal of magnetic resonance imaging : JMRI.

[19]  H. Rusinek,et al.  Dynamic contrast-enhanced MR imaging of the liver: current status and future directions. , 2009, Magnetic resonance imaging clinics of North America.

[20]  Maximilian Reiser,et al.  Quantification of cerebral blood flow, cerebral blood volume, and blood–brain‐barrier leakage with DCE‐MRI , 2009, Magnetic resonance in medicine.

[21]  E de Kerviler,et al.  Contrast agents in magnetic resonance imaging of the liver: present and future. , 1998, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[22]  M Kormano,et al.  Liver Perfusion Studied with Ultrafast CT , 1995, Journal of computer assisted tomography.

[23]  T. Nagao,et al.  Diagnostic efficacy of gadoxetic acid-enhanced MRI for hepatocellular carcinoma and dysplastic nodule. , 2011, World journal of gastroenterology.

[24]  D. Gouma,et al.  Assessment of Future Remnant Liver Function Using Hepatobiliary Scintigraphy in Patients Undergoing Major Liver Resection , 2009, Journal of Gastrointestinal Surgery.

[25]  C S Patlak,et al.  Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data , 1983, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[26]  A. Befeler,et al.  The safety of intra-abdominal surgery in patients with cirrhosis: model for end-stage liver disease score is superior to Child-Turcotte-Pugh classification in predicting outcome. , 2005, Archives of surgery.

[27]  D L Buckley,et al.  Tracer kinetic modelling in MRI: estimating perfusion and capillary permeability , 2012, Physics in medicine and biology.

[28]  C. Thng,et al.  Fundamentals of tracer kinetics for dynamic contrast‐enhanced MRI , 2011, Journal of magnetic resonance imaging : JMRI.

[29]  H. Rusinek,et al.  Advanced liver fibrosis: diagnosis with 3D whole-liver perfusion MR imaging--initial experience. , 2008, Radiology.

[30]  S. Kumano,et al.  Hypervascular hepatocellular carcinomas: detection with gadoxetate disodium-enhanced MR imaging and multiphasic multidetector CT , 2012, European Radiology.

[31]  G. Gores,et al.  Cellular and molecular mechanisms of liver injury. , 2008, Gastroenterology.