Nitric oxide production and absorption in trachea, bronchi, bronchioles, and respiratory bronchioles of humans.

Different volumes of dead-space gas were collected and analyzed for nitric oxide (NO) content, either immediately after inspiration or after a period of breath holding on clean air or NO mixtures. This allowed calculation of NO equilibrium, NO production, and NO absorption. In seven young, healthy, adult nonsmokers, the mean NO equilibrium values in parts per billion (ppb) were 56 +/- 11 (SE) in the trachea, 37 +/- 6 in the bronchi, 21 +/- 3 in the bronchioles, and 16 +/- 2 in the respiratory bronchioles. At any given NO concentration, the NO absorption rate (in nl/min) equaled the NO concentration (in ppb) times A (the absorption coefficient in l/min). A values (in l/min) were 0.11 +/- 0.01 in the trachea, 0.17 +/- 0. 04 in the bronchi, 0.66 +/- 0.09 in the bronchioles, and 1.35 +/- 0. 32 in the respiratory bronchioles. NO equilibrium concentrations and production rates in one 74-yr-old subject were three to five times as high as those found in the young subjects. Mouth equilibrium NO concentrations were 3 and 6 parts per million in two subjects who had oral production rates of 6 and 23 nl/min, respectively. In conclusion, production and absorption of NO occur throughout the first 450 ml of the airways.

[1]  A. B. Dubois,et al.  Comparison between the uptake of nitrous oxide and nitric oxide in the human nose. , 1998, Journal of applied physiology.

[2]  J. Stitt,et al.  Production and absorption of nitric oxide gas in the nose. , 1998, Journal of applied physiology.

[3]  S. Lindberg,et al.  Effects of Nitric Oxide on Blood Flow and Mucociliary Activity in the Human Nose , 1998, The Annals of otology, rhinology, and laryngology.

[4]  R. Forster,et al.  Determination of production of nitric oxide by lower airways of humans--theory. , 1997, Journal of applied physiology.

[5]  Arthur S Slutsky,et al.  Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide. , 1997, American journal of respiratory and critical care medicine.

[6]  H. Makita,et al.  Production of nitric oxide (NO) in intrathoracic airways of normal humans. , 1996, American journal of respiratory and critical care medicine.

[7]  V Hampl,et al.  Origins of breath nitric oxide in humans. , 1996, Chest.

[8]  K. Hirata,et al.  Role of endogenous nitric oxide in airflow obstruction in smokers. , 1996, Chest.

[9]  B. Nejadnik,et al.  Nasal contribution to exhaled nitric oxide at rest and during breathholding in humans. , 1996, American journal of respiratory and critical care medicine.

[10]  Y. Shiratori,et al.  Increased Nitric Oxide in the Exhaled Air of Patients with Decompensated Liver Cirrhosis , 1995, Annals of Internal Medicine.

[11]  D M Hansell,et al.  Elevated levels of exhaled nitric oxide in bronchiectasis. , 1995, American journal of respiratory and critical care medicine.

[12]  C. Leifert,et al.  Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate , 1995, Nature Medicine.

[13]  E. Weitzberg,et al.  Nasally exhaled nitric oxide in humans originates mainly in the paranasal sinuses. , 1994, Acta physiologica Scandinavica.

[14]  E. Weitzberg,et al.  Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome. , 1994, The European respiratory journal.

[15]  P. J. Barnes,et al.  Increased nitric oxide in exhaled air of asthmatic patients , 1994, The Lancet.

[16]  T. Colby,et al.  Immunohistochemical localization of transforming growth factor-beta 1 in the nonnecrotizing granulomas of pulmonary sarcoidosis. , 1994, American journal of respiratory and critical care medicine.

[17]  N. Wiklund,et al.  Endogenous nitric oxide in single exhalations and the change during exercise. , 1993, The American review of respiratory disease.

[18]  E. Weitzberg,et al.  Increased amount of nitric oxide in exhaled air of asthmatics. , 1993, The European respiratory journal.

[19]  S Moncada,et al.  Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. , 1991, Biochemical and biophysical research communications.

[20]  P. Vaida,et al.  Determination of lung capillary blood volume and membrane diffusing capacity in man by the measurements of NO and CO transfer. , 1987, Respiration physiology.

[21]  F. Plum.  Handbook of Physiology. , 1960 .